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Yeah, most GLP-1 benefits (or even adverse effects, like muscle loss) seem to be caused by the weight loss. We already knew obesity massively increases risk fro
by stavros 1y ago
Yeah, most GLP-1 benefits (or even adverse effects, like muscle loss) seem to be caused by the weight loss. We already knew obesity massively increases risk from a host of diseases, but GLP-1s are still treated with scepticism of the "oh but what about the side-effects we don't know about?!" variety?
- ed 1y agoSource? There’s growing evidence of cardioprotective effects independent of weight loss. Eg https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01375-3/fulltext https://www.thelancet.com/journals/lancet/article/PIIS0140-6... > The cardioprotective effects of semaglutide were independent of baseline adiposity and weight loss and had only a small association with waist circumference, suggesting some mechanisms for benefit beyond adiposity reduction.
- rickydroll 1y agoThey also help with slowing the progression of CKD https://www.kidneyfund.org/treatments/medicines-kidney-disease/glp-1-ras https://www.kidneyfund.org/treatments/medicines-kidney-disea...
- anovikov 1y agoSomeone has to start a study where they give GLP-1 to skinny people and see what happens. Why it hasn't been done yet?
- stavros 1y agoBecause they lose weight and it's too dangerous.
- anovikov 1y agoThey won't, GLP-1 has almost no direct effect on skinny people. Many women with BMI around 22-23 are trying them to lose weight to match beauty standards and usually end up disappointed, not able to drop more than 1-2 kilos.