12 ms·

What is the word on the best current and ubiquitous prophylactics, like you said Vit D(3?)

mobilejdral 1y ago
For this particular situation on D3 I personally (who is not your doctor) would go with vitamin D3-loaded nanoemulsion. The reason is that Vit D influences how tryptophan is converted down the 5-HTP and serotonin path or the Kynurenine path. We want higher serotonin AND specifically in the brain. The higher serotonin means better melatonin which not only increase sleep, but increase the ERα expression which we are trying to increase... in the brain. There is a recent study on this showing how this form can provide better results in the brain. https://www.sciencedirect.com/science/article/pii/S3050474025000205 https://www.sciencedirect.com/science/article/pii/S305047402... In general: Omega-3, bcomplex with choline etc all have studies. Really it depends on the individual and what their genetic weakest issue is. Its old and boring, but eat healthy, don't eat before bed, exercise (dance!), and get good sleep always apply.
- Obscurity4340 1y ago
  Are you aware of any association with stimulant treatment re alzheimers? Probably the sleep?
- wyldfire 1y ago
  > with vitamin D3-loaded nanoemulsion This is a substance that is used as a dietary supplement? Or how is it delivered?
DarkmSparks 1y ago
last I heard everything amyloid/plaque burden was suspect after https://www.nytimes.com/2023/07/19/us/stanford-president-resigns-tessier-lavigne.html https://www.nytimes.com/2023/07/19/us/stanford-president-res... It looks very much like they are a symptom rather than a cause. They have got very good at medicines that remove amyloid/plaques, they only physical outcome was massive brain bleeds and death, plus a little https://www.ncbi.nlm.nih.gov/search/research-news/13804/ https://www.ncbi.nlm.nih.gov/search/research-news/13804/ before being withdrawn for all the reasons they resigned https://www.pharmaceutical-technology.com/analyst-comment/biogen-discontinues-aduhelm-alzheimers/ https://www.pharmaceutical-technology.com/analyst-comment/bi... absolute disaster :(
- freddie_mercury 1y ago
  Not really true. See for instance this link "Opponents call the amyloid hypothesis zombie science, propped up only by pharmaceutical companies hoping to sell off a few more anti-amyloid me-too drugs before it collapses. Meanwhile, mainstream scientists . . . continue to believe it without really offering any public defense. Scott was so surprised by the size of the gap between official and unofficial opinion that he asked if someone from the orthodox camp would speak out in its favor." https://www.astralcodexten.com/p/in-defense-of-the-amyloid-hypothesis https://www.astralcodexten.com/p/in-defense-of-the-amyloid-h...
  - DarkmSparks 1y ago
    From that link "and only slow progression a relatively small amount." They don't even do that. they _do_ remove plaques, they _do not_ have any statistically significant effect on MMSE degradation. plus I only see the comments that point out the entire scientific basis for them was based on faked research. The way I had it "simply" described was "the plaques are basically dead brain cells, the problem is the brain cells rapidly dieing, not cleaning up the corpses afterwards". either way, the faked research set dementia research back at least 2 decades and wasted billions of dollars on failed medications with no benefits and horrific side effects (that they tried to cover up).
    - DougMerritt 1y ago
      Yep; this has frustrated me for two decades.
    - _jsmh 1y ago
      Dale Bredsen says the fundamental nature of Alzheimer's is a network insufficiency. [redacted] in https://x.com/MetabolicFactor/status/1918558438440739258 https://x.com/MetabolicFactor/status/1918558438440739258
- pedalpete 1y ago
  Tau and it's relationship to Amyloid, are the current top hypothesis. Another way to look at why the removal of amyloid may not be effective in repairing damage is to think of it like a blocked pipe. A pipe gets blocked, and the pipe itself gets damaged, causing a leak. The block can be removed, but that doesn't repair the pipe. In my example, the pharmaceuticals are removing the blockage, but the damage is still done. Having said that, I believe that as we learn more about what we currently call Alzheimer's, we'll discover that we've been lumping multiple diseases under a single label. I believe the amyloid hypothesis, and Type 3 diabetes hypothesis, both have merit. There may well be others.

For this particular situation on D3 I personally (who is not your doctor) would go with vitamin D3-loaded nanoemulsion. The reason is that Vit D influences how tryptophan is converted down the 5-HTP and serotonin path or the Kynurenine path. We want higher serotonin AND specifically in the brain. The higher serotonin means better melatonin which not only increase sleep, but increase the ERα expression which we are trying to increase... in the brain. There is a recent study on this showing how this form can provide better results in the brain. https://www.sciencedirect.com/science/article/pii/S3050474025000205 https://www.sciencedirect.com/science/article/pii/S305047402... In general: Omega-3, bcomplex with choline etc all have studies. Really it depends on the individual and what their genetic weakest issue is. Its old and boring, but eat healthy, don't eat before bed, exercise (dance!), and get good sleep always apply.

Obscurity4340 1y ago
Are you aware of any association with stimulant treatment re alzheimers? Probably the sleep?
wyldfire 1y ago
> with vitamin D3-loaded nanoemulsion This is a substance that is used as a dietary supplement? Or how is it delivered?

DarkmSparks 1y ago

last I heard everything amyloid/plaque burden was suspect after https://www.nytimes.com/2023/07/19/us/stanford-president-resigns-tessier-lavigne.html https://www.nytimes.com/2023/07/19/us/stanford-president-res... It looks very much like they are a symptom rather than a cause. They have got very good at medicines that remove amyloid/plaques, they only physical outcome was massive brain bleeds and death, plus a little https://www.ncbi.nlm.nih.gov/search/research-news/13804/ https://www.ncbi.nlm.nih.gov/search/research-news/13804/ before being withdrawn for all the reasons they resigned https://www.pharmaceutical-technology.com/analyst-comment/biogen-discontinues-aduhelm-alzheimers/ https://www.pharmaceutical-technology.com/analyst-comment/bi... absolute disaster :(

freddie_mercury 1y ago
Not really true. See for instance this link "Opponents call the amyloid hypothesis zombie science, propped up only by pharmaceutical companies hoping to sell off a few more anti-amyloid me-too drugs before it collapses. Meanwhile, mainstream scientists . . . continue to believe it without really offering any public defense. Scott was so surprised by the size of the gap between official and unofficial opinion that he asked if someone from the orthodox camp would speak out in its favor." https://www.astralcodexten.com/p/in-defense-of-the-amyloid-hypothesis https://www.astralcodexten.com/p/in-defense-of-the-amyloid-h...
- DarkmSparks 1y ago
  From that link "and only slow progression a relatively small amount." They don't even do that. they _do_ remove plaques, they _do not_ have any statistically significant effect on MMSE degradation. plus I only see the comments that point out the entire scientific basis for them was based on faked research. The way I had it "simply" described was "the plaques are basically dead brain cells, the problem is the brain cells rapidly dieing, not cleaning up the corpses afterwards". either way, the faked research set dementia research back at least 2 decades and wasted billions of dollars on failed medications with no benefits and horrific side effects (that they tried to cover up).
  - DougMerritt 1y ago
    Yep; this has frustrated me for two decades.
  - _jsmh 1y ago
    Dale Bredsen says the fundamental nature of Alzheimer's is a network insufficiency. [redacted] in https://x.com/MetabolicFactor/status/1918558438440739258 https://x.com/MetabolicFactor/status/1918558438440739258
pedalpete 1y ago
Tau and it's relationship to Amyloid, are the current top hypothesis. Another way to look at why the removal of amyloid may not be effective in repairing damage is to think of it like a blocked pipe. A pipe gets blocked, and the pipe itself gets damaged, causing a leak. The block can be removed, but that doesn't repair the pipe. In my example, the pharmaceuticals are removing the blockage, but the damage is still done. Having said that, I believe that as we learn more about what we currently call Alzheimer's, we'll discover that we've been lumping multiple diseases under a single label. I believe the amyloid hypothesis, and Type 3 diabetes hypothesis, both have merit. There may well be others.