3 ms·

> wouldn't mind 10x a day injections if it keeps Alzheimer's at bay. Actually, I wouldn't mind a continuous IV drip. There seems to be a much better way: http

by trhway 1y ago

> wouldn't mind 10x a day injections if it keeps Alzheimer's at bay. Actually, I wouldn't mind a continuous IV drip. There seems to be a much better way: https://publichealth.jhu.edu/2025/small-amounts-of-moderate-to-vigorous-physical-activity-are-associated-with-big-reductions-in-dementia-risk https://publichealth.jhu.edu/2025/small-amounts-of-moderate-... "The researchers found that engaging in as little as 35 minutes of moderate to vigorous physical activity per week, compared to zero minutes per week, was associated with a 41% lower risk of developing dementia over an average four-year follow-up period. Even for frail older adults—those at elevated risk of adverse health outcomes—greater activity was associated with lower dementia risks. The researchers found dementia risk decreased with higher amounts of physical activity. Dementia risks were 60% lower in participants in the 35 to 69.9 minutes of physical activity/week category; 63% lower in the 70 to 139.9 minutes/week category; and 69% lower in the 140 and over minutes/week category."

lm28469 1y ago
People keep telling they'd sacrifice everyting for an hypothetical silver bullets while doing nothing in their day to day life to mitigate all these disease. Eat clean, exercise, 8 hours of deep good uninterrupted sleep, &c. 3/4th of people are obese or overweight, the average Joe walks like 4k steps a day, people, at large, don't give a shit about health until they get a terminal diagnosis
- coldtea 1y ago
  >the average Joe walks like 4k steps a day Which is not that bad. 10k/steps was a made up marketing goal from a speedometer company. The sweet spot is around 7k/steps day, but 4k/steps day is already seeing benefits.
- foldr 1y ago
  Not everyone can just choose to get 8 hours of uninterrupted sleep! I’d love to.
jbstack 1y ago
Apples and oranges. You're talking about prevention, but this is about cure / treatment. Once you have already have Alzheimer's, exercise isn't going to save you.
- coldtea 1y ago
  >You're talking about prevention, but this is about cure / treatment Not "apples vs oranges". More like "diabetes vs healthy diet". Most wouldn't need treatment if they worked at prevention.
scotty79 1y ago
What am I to infer from this? That people prone to dementia tend to have less energy for voluntary vigorous physical activity? If not, why not?
- trhway 1y ago
  >vigorous physical activity 140 minutes/week is really really far from vigorous.
  - mathgeek 1y ago
    Might be confusing terms here. Vigorous exercise tends to describe high intensity rather than high volume.
  - kadoban 1y ago
    "vigorous" isn't a period of time or an amount of time per week. It describes the level of physical activity, not the amount.
Zababa 1y ago
Doesn't fully correct for different biaises like healthy user bias so it proves association more than causality.
vintermann 1y ago
My father was very active well into his 80s, going for 10+km bike rides almost every day, until he got heart trouble. He would still walk for hours every day, often taking the stairs up the local hill, 400+ steps. He still got Alzheimer's. A lighter, later case than he would otherwise had, I'm sure, but still, he doesn't remember what he said 2 minutes ago, asking about the same things over and over again. So while there are lots of excellent reasons to stay active into old age, it's not a replacement for treatment.

by trhway 1y ago

lm28469 1y ago

People keep telling they'd sacrifice everyting for an hypothetical silver bullets while doing nothing in their day to day life to mitigate all these disease. Eat clean, exercise, 8 hours of deep good uninterrupted sleep, &c. 3/4th of people are obese or overweight, the average Joe walks like 4k steps a day, people, at large, don't give a shit about health until they get a terminal diagnosis

coldtea 1y ago
>the average Joe walks like 4k steps a day Which is not that bad. 10k/steps was a made up marketing goal from a speedometer company. The sweet spot is around 7k/steps day, but 4k/steps day is already seeing benefits.
foldr 1y ago
Not everyone can just choose to get 8 hours of uninterrupted sleep! I’d love to.

jbstack 1y ago

Apples and oranges. You're talking about prevention, but this is about cure / treatment. Once you have already have Alzheimer's, exercise isn't going to save you.

coldtea 1y ago
>You're talking about prevention, but this is about cure / treatment Not "apples vs oranges". More like "diabetes vs healthy diet". Most wouldn't need treatment if they worked at prevention.

scotty79 1y ago

What am I to infer from this? That people prone to dementia tend to have less energy for voluntary vigorous physical activity? If not, why not?

trhway 1y ago
>vigorous physical activity 140 minutes/week is really really far from vigorous.
- mathgeek 1y ago
  Might be confusing terms here. Vigorous exercise tends to describe high intensity rather than high volume.
- kadoban 1y ago
  "vigorous" isn't a period of time or an amount of time per week. It describes the level of physical activity, not the amount.

Zababa 1y ago

Doesn't fully correct for different biaises like healthy user bias so it proves association more than causality.

vintermann 1y ago

My father was very active well into his 80s, going for 10+km bike rides almost every day, until he got heart trouble. He would still walk for hours every day, often taking the stairs up the local hill, 400+ steps. He still got Alzheimer's. A lighter, later case than he would otherwise had, I'm sure, but still, he doesn't remember what he said 2 minutes ago, asking about the same things over and over again. So while there are lots of excellent reasons to stay active into old age, it's not a replacement for treatment.