3 ms·
>Remember, there's no reversal agent or half-life elimination for such genetic treatments. Another virus that removes/breaks the inserted gene?
by meindnoch 1y ago
>Remember, there's no reversal agent or half-life elimination for such genetic treatments.
Another virus that removes/breaks the inserted gene?
- Den_VR 1y agoMentioning that might have just been Guardrails…
- vibrio 1y agoThe bane of most gene therapy research is lack of persistence. With how serious and morbid HD is, I’d guess patients will take their chances.
- pas 1y agoif I understand correctly it only injects a "gene cassette" which forms an episome (a plasmid-like thing, ie. just a ring of DNA outside the nucleus, just floating around in the cell), so it's non-integrating https://youtu.be/q8HIubDJiMI?t=41 https://youtu.be/q8HIubDJiMI?t=41