5 ms·
5mg/kg? 1g of shrooms has something like 5-20mg of psilocybin. An equivalent human dose would seem to be 1.3-2.6g a day Edit: Did the math wrong.
by andoando 1y ago
5mg/kg? 1g of shrooms has something like 5-20mg of psilocybin. An equivalent human dose would seem to be 1.3-2.6g a day
Edit: Did the math wrong.
- tombakt 1y agoAh yes, a proper morning routine. A bit of coffee, exercise, becoming one with the void…
- samtp 1y agoWell your perception of time would certainly be longer at that dose. Probably feel like you've lived for centuries.
- firtoz 1y agoI can confirm. The wheel turned many times.
- shawabawa3 1y agoYour two statements contradict If 1g of shrooms has 5mg psilocybin, to get a dose of 5mg/kg would be like 75g for an average man (still feels very high but nowhere near 1kg)
- andoando 1y agoSorry did the math completely wrong. And this was a monthly dose, for 75g thats ~2.5g a day
- neom 1y ago"First, we sought to model high-dose used in a clinical study for chronic pain, where patients were administered a psychedelic dose (25 mg) of psilocybin. Using the standard allometric scaling method, a human dose of 25 mg of psilocybin translates to a mouse dose of approximately 5.14 mg/kg."
- andoando 1y agoInteresting. I thought linear would obviously be incorrect, but didn't think it scaled so strongly. At 25mg, thats 2.5g first month and 7.5g monthly afterwards. I wonder if the effects are the same with monthly injections vs daily though.
- titanomachy 1y agoI don’t think you multiplied quite right. An 80-kg person would need 400mg, which would take 40g of shrooms if potency is 10mg per dried gram. That would still be 10 times larger than a regular dose. I think that would make most people seriously ill, not to mention the mental effects. One must assume that mice respond differently than humans.
- andoando 1y agoYeah someone also brought up that its not a linear scaling. https://pmc.ncbi.nlm.nih.gov/articles/PMC4804402/ https://pmc.ncbi.nlm.nih.gov/articles/PMC4804402/ And the study calculates it a 5mg for rats as 25mg for humans.
- deleted 1y ago[deleted]
- yusaydat 1y agoIt's 5 mg/kg (or 15 mg/kg due to faster metabolism) for rats, and 25 mg (not per kg!) for humans. To be clear, 25 mg is a completely normal dosage that has been used in previous human studies.
- leoh 1y agoAfter a few days, such a dose would likely become imperceptible in “healthy normals.”