8 ms·

This is from 2016, a lot has happened since then: - The FDA recognized psilocybin as a breakthrough therapy for treatment-resistant depression: https://www.prn

by Youden 1y ago

This is from 2016, a lot has happened since then: - The FDA recognized psilocybin as a breakthrough therapy for treatment-resistant depression: https://www.prnewswire.com/news-releases/compass-pathways-receives-fda-breakthrough-therapy-designation-for-psilocybin-therapy-for-treatment-resistant-depression-834088100.html https://www.prnewswire.com/news-releases/compass-pathways-re... - Some more studies, such as https://pubmed.ncbi.nlm.nih.gov/27909164/ https://pubmed.ncbi.nlm.nih.gov/27909164/ - More widespread use in medical treatment, such as approval in Australia (https://www.bbc.com/news/world-australia-66072427 https://www.bbc.com/news/world-australia-66072427) and limited approval in Switzerland Very much anecdotal but I can say that psychedelics helped me and several friends a lot with depression. They don't just magically make you feel better - at least not long-term - but they give you the neuroplasticity you need to adjust your internal filters and behaviour. As such, if the purpose is truly healing and recovery, they're best paired with professional therapy, preferably from somebody who's experienced with psychedelic-assisted therapy specifically.

tuesdaynight 1y ago
I don't have depression, but the first time I used psychedelics was so emotional helpful that I strongly suggested for depressed friends. I corrected that mistake hours later, after realizing that the risks are low, but life changing if it happens. However, I will never forget that feeling. I've used it again in the following years, but the results faded and it became boring for me.
- rjxc 1y ago
  What are the low-but-life-changing risks?
  - causality0 1y ago
    Some people report personality changes, some as radical as "I found I didn't love my husband anymore."
    - BiteCode_dev 1y ago
      That's not a risk, that's a realization. You need those. You may have saved 20 years in an unhappy marriage.
      - Aurornis 1y ago
        The risk is that it’s a false idea triggered by the psychedelic. Maybe a better example would be my friend who took psychedelics and then believed he was in communication with Elon Musk. This one is more obviously a false idea, but nevertheless he was convinced it was real for a period after the psychedelic experience. There’s a mystical concept that psychedelics open your third eye to see the world as it really is or something, but psychedelics are notorious for giving false ideas and making them seem like revelations. It’s obvious when it’s nonsense (like telepathy with Elon Musk) but it’s less obvious when the implanted idea is something like “your husband secretly doesn’t love you”. Another strangely common report is the belief that people around you have been replaced by clones, which can get scary very fast if the person can’t separate the idea from reality.
        AppleBananaPie 1y ago
        Yeah I agree with you 100%. it's interesting folks immediately taking the experience and result at face value when we understand so little about what's happening, even without psychedelics is most cases. In the referenced anecdote it could be as simple as an excuse needed for someone who's been thinking about it for years. Though maybe that's enough to be a benefit Anyway I like your example and look forward to what is learned about using psychedelics to help people :)
        armonster 1y ago
        It sounds like your friend had a predilection for psychosis. I feel like the nice things about psychedelics is that they don't alter my processing too much (as compared with other drugs), moreso they just give me different 'inputs' into my senses / experiences, and then I process those.
        1y ago
  - anon6959 1y ago
    Exacerbation (and possibly development) of mental illness like psychosis, bipolar disorder, or schizophrenia is entirely possible. Along with two other blokes, I got interested in psychedelics in high school. Took one medium high dose and wasn't right for a few months. Never in my life did i ever experienced paranoia, delusions, or hallucinations that are genuinely hard to separate from reality, but I did after that. Intense psychedelic experiences can fracture what you once knew as "reality" allows all sorts of ideas to float into your mind, with equal possibility. This might be helpful and give you more flexible thinking (helpful for depression) but it also leaves you incredible vulnerable to all sorts of garbage ideas that you never would have considered otherwise. ie conspiracy theories or straight up delusions about the supernatural. Remember: It's not paranoia if you genuinely believe they really are out to get you! Fighting these garbage ideas is a lot of work once they take hold, but you'll only know too late if you were vulnerable, and worse, if you can successfully align your understanding of reality with most other people. I got extremely lucky that I stabilized. I'm convinced part of this was only doing it one time. My two co-experimenters took many trips with various doses are still in and out of mental hospitals years later. Psychedelics are incredibly potent and nobody really understands them very well. A lot of what is written on the internet ignores, downplays, or denies the very serious risks to your philosophy of mind and mental function. Its like playing with fire when you don't have heat sensation in your hands. Several other comments on this page echo these warnings. One even claims there is an 18% chance you could go from depressed to schizophrenic. I have no idea where that figure came from, but the risk is certainly not 0%
    - hungmung 1y ago
      Just curious, which psychedelics were you guys experimenting with?
    - theragra 1y ago
      Anectodically, this is pretty rare. I know quite a lot of people who used psychedelics, and they are fine. I think some important safety points is to know family history of mental illness and not do then until later in life. And obviously, start low and see how it goes.
  - ActorNightly 1y ago
    Basically it hyper-connects your brain. When people talk about seeing shapes, its not that they are hallucinating, its that when they look at the random fuzz pattern on a rug, and pick out the particles of fuzz that make a creature face, its looks like someone purposefully put those pieces there to make that face. As such, if you are "surfing" thoughts and find an association of something, that association can become very prominent. If you don't have the context to understand why you are making that association, especially after the trip, you can get stuck with beliefs about yourself that could be non optimal. On the flip side this hyperconnectivity also allows you to see things like a completely different person would see them, which is where the true healing power lies. Its like you can be disugsted with a particular food when you are sober, but on shrooms you can truly feel what it would be like to enjoy that food. Once you have that context, you are able to move forward after the trip into right directions. This is why set and setting are EXTREMELY important for significant trips. You want to be with someone who a) has done psychedelics, b) is in a very good mental state, and c) has a low ego not to project their own personality onto you. The best trip sitters are those that encourage exploration - they take everything you communicate to them and ask you questions about it without imparting any bias.
  - foobiekr 1y ago
    HPPD and .. honestly, some people have bad trips, and while it is popular in psychedelic circles to say "There is no such thing as a bad trip just the way you interpret it" that isn't really true. Even Terrence McKenna stopped taking mushrooms for a decade after a bad experience. That said, I _do_ recommend mushrooms to everyone I know with depression or anger issues.
    - coffeebeqn 1y ago
      I had a panic attack one time, not sure how I should “interpret” that one. I’ve get anxiety since childhood for context. That said I’d love to do a session with a professional rather than by myself. Self medication for mental health issues is a bit of a gamble. I’ve also had good experiences even at higher doses so it’s a bit random
- FollowingTheDao 1y ago
  Many people say the first time they use Prozac that it was so helpful they recommended to their friends but then after a while it wore off. How do you think psychedelics work? They activate the serotonin 2a receptor. It’s nothing but a different drug that effects serotonin. Except it does it more intensely but like all these drugs that act on receptors they wear off because of something what’s called receptor density changes. For 70 years, we’ve been trying to manipulate receptors into making people feel good. It’s a losing proposition and it’s time to. We changed our thinking. For instance, if these people do have serotonin deficiencies, which is still possibly the case, what is it? That’s causing these deficiencies? Is it low, zinc, low B6, genetics, infection? There’s so many other things that we know that this could be, but we don’t try it.
  - foobiekr 1y ago
    I think this is naive. A mushroom trip is fully metabolized and cleared in approximately 6-12 hours. Despite the similar levels of reduction in depressive symptoms for the subsequent weeks, the psilocin has been cleared on the day of, unlike prozac, and hasn't been stimulating 5HT2* at all for that afterglow and post-exposure period. Nobody other than crazy micro-dosers is taking mushrooms often enough to cause a change in receptor density and those people are putting themselves at risk of valvopathy due to 5HT2a restructuring of the heart valves (which, as an aside, is turning out to be a problem for people on prozac and other long-term SSRIs). A drug that is very occasional, point use, with no ongoing use, which has long term treatment results, is absolutely, utterly unlike prozac. That aside, let's say for the sake of argument that the mechanism is similar for prozac; I think that's wrong (one additional explanation may actually be: https://www.sciencedirect.com/science/article/abs/pii/S1567576924002716 https://www.sciencedirect.com/science/article/abs/pii/S15675... ) but whatever. If so, then psilocin is vastly superior to prozac because you are not required to have continuous exposure for the benefits, as the corresponding cost, withdrawal, sexual dysfunction, weight gain, heart issues, etc. are removed.
    - FollowingTheDao 1y ago
      > Nobody other than crazy micro-dosers is taking mushrooms often enough to cause a change in receptor density This is so frustrating to me. Why not just google it before you think you know more about this than someone studying it for ten years? Two things can change receptor density: time and dose. A Single Dose of Psilocybin Increases Synaptic Density and Decreases 5-HT2A Receptor Density in the Pig Brain https://pubmed.ncbi.nlm.nih.gov/33467676/ https://pubmed.ncbi.nlm.nih.gov/33467676/ This is exactly why psychedelics last longer than prozac. It has less to do with half life and more to do with dose. How is the mechanism not at least comparative to prozac since it is well know they both effect serotonin? The risk with psilocin is exactly the dose, as many people find out. And you thing there are not cardiac side effects from psychedelics? A Case of Prolonged Mania, Psychosis, and Severe Depression After Psilocybin Use: Implications of Increased Psychedelic Drug Availability https://psychiatryonline.org/doi/full/10.1176/appi.ajp.22010073 https://psychiatryonline.org/doi/full/10.1176/appi.ajp.22010... Worsening suicidal ideation and prolonged adverse event following psilocybin administration in a clinical setting: case report and thematic analysis of one participant's experience https://pmc.ncbi.nlm.nih.gov/articles/PMC11698204/ https://pmc.ncbi.nlm.nih.gov/articles/PMC11698204/ Safety First: Potential Heart Health Risks of Microdosing https://petrieflom.law.harvard.edu/2022/04/13/safety-first-potential-heart-health-risks-of-microdosing/ https://petrieflom.law.harvard.edu/2022/04/13/safety-first-p...
- Aurornis 1y ago
  > after realizing that the risks are low, but life changing if it happens. I think these risks are more common than was previously discussed on the internet. For a long time reports of very negative experiences were dismissed, laughed at, downplayed, waved away as symptoms of something else, or excused as something positive but mysterious. It’s becoming more acceptable for people to discuss their negative experiences and not get downvoted or attacked for sharing them.
  - bongodongobob 1y ago
    Negative experiences have always been a part of it. It's half the point. Negative also doesn't mean permanent, which is extremely rare.
    - Aurornis 1y ago
      > Negative experiences have always been a part of it. It's half the point. This is the type of dismissal and downplaying I’m referring to. My friend descended into psychosis after taking psychedelics. It was not “half the point” and not helpful to his life in any way.
    - nwienert 1y ago
      Not that rare, anyone with predisposition to psychosis/schizophrenia has a high risk of permanent effects, and that’s not that small of a segment of people, and nearly unknowable beforehand.
      - bongodongobob 1y ago
        That is the definition of rare.
        nwienert 1y ago
        Rarity isn’t a catch all, it’s a lot closer to winning $20 on a scratcher than 5k. When the game is Russian Roulette no one should call it rare.
larodi 1y ago
Wonder how Adderall with its fourfold amphetamine recipe can fast-track to market, while psylocibin with all its ancestral approval had not yet been pilled AT ALL. How can a soldier designated pill make it to 60m prescriptions and amazing substantiated illegal use, while psylocibin is still rated as schedule-1 drug alongside heroine, which of course is major offense to possess. https://en.wikipedia.org/wiki/Adderall https://en.wikipedia.org/wiki/Adderall https://en.wikipedia.org/wiki/Psilocybin#History https://en.wikipedia.org/wiki/Psilocybin#History This makes very little sense unless on purpose. I mean, like what, people been doing it for millenniums and still we got where we are now, and not because of downsides of its use, or what?
- dec0dedab0de 1y ago
  Modern drug laws came about in the 1970s, at the height of hippies on psychedelics trying to overthrow the government. People in power fear losing their power, and they saw these drugs as a threat. The weirdest part of the whole thing to me is that they outlawed Cannabis, Psilocybin, and LSD, but kept cocaine legal with a prescription under schedule 2.
  - pstuart 1y ago
    But those modern drug laws picked up where the older drug laws petered out, and in both cases they were intended to punish their users, not protect them.
    - pksebben 1y ago
      To bang a fairly weathered drum, this is largely a matter of conservative policy. Psychedelics were far more common in leftist circles (some might argue that this is cause as opposed to effect - mind-expanding experiences tend to shift politics towards that end of the spectrum). This means that if you wanted to use the law as a political cudgel without being accused of thought-policing, you could outlaw psychedelics and be confident that the blast zone would exclude the politically faithful while locking up loads of political undesirables; like hippies, panthers, etc. Of course, these days you have right-wing podcasters discussing DMT with billionaire CEOs, so it's a little trickier. Thus the tentative steps toward legalization.
pier25 1y ago
Oregon even started giving licenses for psilocybin therapy a year or two ago. https://www.oregon.gov/oha/ph/preventionwellness/pages/psilocybin-license-facilitator.aspx https://www.oregon.gov/oha/ph/preventionwellness/pages/psilo...
teaearlgraycold 1y ago
> at least not long-term To be clear they absolutely do regularly provide short to medium term depression relief (up to a few months). I also know someone who had severe treatment resistant depression that was cured long-term (at least years) from one dose.

by Youden 1y ago

tuesdaynight 1y ago

I don't have depression, but the first time I used psychedelics was so emotional helpful that I strongly suggested for depressed friends. I corrected that mistake hours later, after realizing that the risks are low, but life changing if it happens. However, I will never forget that feeling. I've used it again in the following years, but the results faded and it became boring for me.

rjxc 1y ago
What are the low-but-life-changing risks?
- causality0 1y ago
  Some people report personality changes, some as radical as "I found I didn't love my husband anymore."
  - BiteCode_dev 1y ago
    That's not a risk, that's a realization. You need those. You may have saved 20 years in an unhappy marriage.
    - Aurornis 1y ago
      The risk is that it’s a false idea triggered by the psychedelic. Maybe a better example would be my friend who took psychedelics and then believed he was in communication with Elon Musk. This one is more obviously a false idea, but nevertheless he was convinced it was real for a period after the psychedelic experience. There’s a mystical concept that psychedelics open your third eye to see the world as it really is or something, but psychedelics are notorious for giving false ideas and making them seem like revelations. It’s obvious when it’s nonsense (like telepathy with Elon Musk) but it’s less obvious when the implanted idea is something like “your husband secretly doesn’t love you”. Another strangely common report is the belief that people around you have been replaced by clones, which can get scary very fast if the person can’t separate the idea from reality.
      - AppleBananaPie 1y ago
        Yeah I agree with you 100%. it's interesting folks immediately taking the experience and result at face value when we understand so little about what's happening, even without psychedelics is most cases. In the referenced anecdote it could be as simple as an excuse needed for someone who's been thinking about it for years. Though maybe that's enough to be a benefit Anyway I like your example and look forward to what is learned about using psychedelics to help people :)
      - armonster 1y ago
        It sounds like your friend had a predilection for psychosis. I feel like the nice things about psychedelics is that they don't alter my processing too much (as compared with other drugs), moreso they just give me different 'inputs' into my senses / experiences, and then I process those.
        1y ago
- anon6959 1y ago
  Exacerbation (and possibly development) of mental illness like psychosis, bipolar disorder, or schizophrenia is entirely possible. Along with two other blokes, I got interested in psychedelics in high school. Took one medium high dose and wasn't right for a few months. Never in my life did i ever experienced paranoia, delusions, or hallucinations that are genuinely hard to separate from reality, but I did after that. Intense psychedelic experiences can fracture what you once knew as "reality" allows all sorts of ideas to float into your mind, with equal possibility. This might be helpful and give you more flexible thinking (helpful for depression) but it also leaves you incredible vulnerable to all sorts of garbage ideas that you never would have considered otherwise. ie conspiracy theories or straight up delusions about the supernatural. Remember: It's not paranoia if you genuinely believe they really are out to get you! Fighting these garbage ideas is a lot of work once they take hold, but you'll only know too late if you were vulnerable, and worse, if you can successfully align your understanding of reality with most other people. I got extremely lucky that I stabilized. I'm convinced part of this was only doing it one time. My two co-experimenters took many trips with various doses are still in and out of mental hospitals years later. Psychedelics are incredibly potent and nobody really understands them very well. A lot of what is written on the internet ignores, downplays, or denies the very serious risks to your philosophy of mind and mental function. Its like playing with fire when you don't have heat sensation in your hands. Several other comments on this page echo these warnings. One even claims there is an 18% chance you could go from depressed to schizophrenic. I have no idea where that figure came from, but the risk is certainly not 0%
  - hungmung 1y ago
    Just curious, which psychedelics were you guys experimenting with?
  - theragra 1y ago
    Anectodically, this is pretty rare. I know quite a lot of people who used psychedelics, and they are fine. I think some important safety points is to know family history of mental illness and not do then until later in life. And obviously, start low and see how it goes.
- ActorNightly 1y ago
  Basically it hyper-connects your brain. When people talk about seeing shapes, its not that they are hallucinating, its that when they look at the random fuzz pattern on a rug, and pick out the particles of fuzz that make a creature face, its looks like someone purposefully put those pieces there to make that face. As such, if you are "surfing" thoughts and find an association of something, that association can become very prominent. If you don't have the context to understand why you are making that association, especially after the trip, you can get stuck with beliefs about yourself that could be non optimal. On the flip side this hyperconnectivity also allows you to see things like a completely different person would see them, which is where the true healing power lies. Its like you can be disugsted with a particular food when you are sober, but on shrooms you can truly feel what it would be like to enjoy that food. Once you have that context, you are able to move forward after the trip into right directions. This is why set and setting are EXTREMELY important for significant trips. You want to be with someone who a) has done psychedelics, b) is in a very good mental state, and c) has a low ego not to project their own personality onto you. The best trip sitters are those that encourage exploration - they take everything you communicate to them and ask you questions about it without imparting any bias.
- foobiekr 1y ago
  HPPD and .. honestly, some people have bad trips, and while it is popular in psychedelic circles to say "There is no such thing as a bad trip just the way you interpret it" that isn't really true. Even Terrence McKenna stopped taking mushrooms for a decade after a bad experience. That said, I _do_ recommend mushrooms to everyone I know with depression or anger issues.
  - coffeebeqn 1y ago
    I had a panic attack one time, not sure how I should “interpret” that one. I’ve get anxiety since childhood for context. That said I’d love to do a session with a professional rather than by myself. Self medication for mental health issues is a bit of a gamble. I’ve also had good experiences even at higher doses so it’s a bit random
FollowingTheDao 1y ago
Many people say the first time they use Prozac that it was so helpful they recommended to their friends but then after a while it wore off. How do you think psychedelics work? They activate the serotonin 2a receptor. It’s nothing but a different drug that effects serotonin. Except it does it more intensely but like all these drugs that act on receptors they wear off because of something what’s called receptor density changes. For 70 years, we’ve been trying to manipulate receptors into making people feel good. It’s a losing proposition and it’s time to. We changed our thinking. For instance, if these people do have serotonin deficiencies, which is still possibly the case, what is it? That’s causing these deficiencies? Is it low, zinc, low B6, genetics, infection? There’s so many other things that we know that this could be, but we don’t try it.
- foobiekr 1y ago
  I think this is naive. A mushroom trip is fully metabolized and cleared in approximately 6-12 hours. Despite the similar levels of reduction in depressive symptoms for the subsequent weeks, the psilocin has been cleared on the day of, unlike prozac, and hasn't been stimulating 5HT2* at all for that afterglow and post-exposure period. Nobody other than crazy micro-dosers is taking mushrooms often enough to cause a change in receptor density and those people are putting themselves at risk of valvopathy due to 5HT2a restructuring of the heart valves (which, as an aside, is turning out to be a problem for people on prozac and other long-term SSRIs). A drug that is very occasional, point use, with no ongoing use, which has long term treatment results, is absolutely, utterly unlike prozac. That aside, let's say for the sake of argument that the mechanism is similar for prozac; I think that's wrong (one additional explanation may actually be: https://www.sciencedirect.com/science/article/abs/pii/S1567576924002716 https://www.sciencedirect.com/science/article/abs/pii/S15675... ) but whatever. If so, then psilocin is vastly superior to prozac because you are not required to have continuous exposure for the benefits, as the corresponding cost, withdrawal, sexual dysfunction, weight gain, heart issues, etc. are removed.
  - FollowingTheDao 1y ago
    > Nobody other than crazy micro-dosers is taking mushrooms often enough to cause a change in receptor density This is so frustrating to me. Why not just google it before you think you know more about this than someone studying it for ten years? Two things can change receptor density: time and dose. A Single Dose of Psilocybin Increases Synaptic Density and Decreases 5-HT2A Receptor Density in the Pig Brain https://pubmed.ncbi.nlm.nih.gov/33467676/ https://pubmed.ncbi.nlm.nih.gov/33467676/ This is exactly why psychedelics last longer than prozac. It has less to do with half life and more to do with dose. How is the mechanism not at least comparative to prozac since it is well know they both effect serotonin? The risk with psilocin is exactly the dose, as many people find out. And you thing there are not cardiac side effects from psychedelics? A Case of Prolonged Mania, Psychosis, and Severe Depression After Psilocybin Use: Implications of Increased Psychedelic Drug Availability https://psychiatryonline.org/doi/full/10.1176/appi.ajp.22010073 https://psychiatryonline.org/doi/full/10.1176/appi.ajp.22010... Worsening suicidal ideation and prolonged adverse event following psilocybin administration in a clinical setting: case report and thematic analysis of one participant's experience https://pmc.ncbi.nlm.nih.gov/articles/PMC11698204/ https://pmc.ncbi.nlm.nih.gov/articles/PMC11698204/ Safety First: Potential Heart Health Risks of Microdosing https://petrieflom.law.harvard.edu/2022/04/13/safety-first-potential-heart-health-risks-of-microdosing/ https://petrieflom.law.harvard.edu/2022/04/13/safety-first-p...
Aurornis 1y ago
> after realizing that the risks are low, but life changing if it happens. I think these risks are more common than was previously discussed on the internet. For a long time reports of very negative experiences were dismissed, laughed at, downplayed, waved away as symptoms of something else, or excused as something positive but mysterious. It’s becoming more acceptable for people to discuss their negative experiences and not get downvoted or attacked for sharing them.
- bongodongobob 1y ago
  Negative experiences have always been a part of it. It's half the point. Negative also doesn't mean permanent, which is extremely rare.
  - Aurornis 1y ago
    > Negative experiences have always been a part of it. It's half the point. This is the type of dismissal and downplaying I’m referring to. My friend descended into psychosis after taking psychedelics. It was not “half the point” and not helpful to his life in any way.
  - nwienert 1y ago
    Not that rare, anyone with predisposition to psychosis/schizophrenia has a high risk of permanent effects, and that’s not that small of a segment of people, and nearly unknowable beforehand.
    - bongodongobob 1y ago
      That is the definition of rare.
      - nwienert 1y ago
        Rarity isn’t a catch all, it’s a lot closer to winning $20 on a scratcher than 5k. When the game is Russian Roulette no one should call it rare.

larodi 1y ago

Wonder how Adderall with its fourfold amphetamine recipe can fast-track to market, while psylocibin with all its ancestral approval had not yet been pilled AT ALL. How can a soldier designated pill make it to 60m prescriptions and amazing substantiated illegal use, while psylocibin is still rated as schedule-1 drug alongside heroine, which of course is major offense to possess. https://en.wikipedia.org/wiki/Adderall https://en.wikipedia.org/wiki/Adderall https://en.wikipedia.org/wiki/Psilocybin#History https://en.wikipedia.org/wiki/Psilocybin#History This makes very little sense unless on purpose. I mean, like what, people been doing it for millenniums and still we got where we are now, and not because of downsides of its use, or what?

dec0dedab0de 1y ago
Modern drug laws came about in the 1970s, at the height of hippies on psychedelics trying to overthrow the government. People in power fear losing their power, and they saw these drugs as a threat. The weirdest part of the whole thing to me is that they outlawed Cannabis, Psilocybin, and LSD, but kept cocaine legal with a prescription under schedule 2.
- pstuart 1y ago
  But those modern drug laws picked up where the older drug laws petered out, and in both cases they were intended to punish their users, not protect them.
  - pksebben 1y ago
    To bang a fairly weathered drum, this is largely a matter of conservative policy. Psychedelics were far more common in leftist circles (some might argue that this is cause as opposed to effect - mind-expanding experiences tend to shift politics towards that end of the spectrum). This means that if you wanted to use the law as a political cudgel without being accused of thought-policing, you could outlaw psychedelics and be confident that the blast zone would exclude the politically faithful while locking up loads of political undesirables; like hippies, panthers, etc. Of course, these days you have right-wing podcasters discussing DMT with billionaire CEOs, so it's a little trickier. Thus the tentative steps toward legalization.

pier25 1y ago

Oregon even started giving licenses for psilocybin therapy a year or two ago. https://www.oregon.gov/oha/ph/preventionwellness/pages/psilocybin-license-facilitator.aspx https://www.oregon.gov/oha/ph/preventionwellness/pages/psilo...

teaearlgraycold 1y ago

> at least not long-term To be clear they absolutely do regularly provide short to medium term depression relief (up to a few months). I also know someone who had severe treatment resistant depression that was cured long-term (at least years) from one dose.