3 ms·

It is my understanding that we have tried anti inflammatory interventions and they didn’t help. So the conclusion that inflammation per se is not the problem se

• amelius 1y ago
  Are you sure the side effects of the interventions were not the problem?
• k__ 1y ago
  I dimmly remember Japanese research about how fasting induced autophagy could help.
• elcritch 1y ago
  There’s dozens of pro-inflammatory signaling proteins. Our anti-inflammatories really only target a small subset of them. Ideally you need to stop inflammatory signals at the source, but we understand very few of those.
  • cryzinger 1y ago
    It's also frustrating how, for the targeted anti-inflammatories we do have, there's no real way to know which one will be the most effective for someone other than trying several until you find one that does. More options are always better, but many common autoimmune conditions have approved drugs that target TNF, JAK, and four or five different interleukins... it'd be nice if there was a predictive blood test that showed whether you had abnormally high levels of any of those targets so you didn't have to guess wildly. (And even then, there are at least a few overlapping drugs for each of those targets, but at least "try an IL-17 inhibitor" gives you a smaller pool :P)