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Brain aging shows nonlinear transitions, suggesting a midlife "critical window"
- adaisadais 1y agoCan someone give me a TL;DR?
- aldanor 1y agoKeto diet makes your brain use ketones instead of glucose for fuel which results in slower brain aging when you're 40-50.
- bravesoul2 1y agoI wonder is keto on then off better or always on. On then off might let you get more variety in.
- moi2388 1y agoVariety is the spicy of life, and all things in moderation.
- aldanor 1y agoIt's like asking if on and off cocaine is better than always off... sugar being a sort of cocaine-like thing for the brain. One thing to note here is that ketosis may be achieved by diets less strict like MAD etc.
- BennyH26 1y agoTLDR; • As people get older, their brain connections start to break down faster in midlife (around 40–60 years) because brain cells don’t use sugar as well. • Giving the brain a different fuel called ketones can help keep those connections strong during this middle‐age window. • This suggests that helping the brain get fuel in midlife could keep it healthier and slow down memory problems later on. You can ingest ketones on their own (generally expensive supplements), but this article is more interesting in that a ketogenic diet (very low carbs) may have similar benefits.
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- tom_ 1y agoIf you're worried about your brain, reading the entire article might be good exercise for it.
- jader201 1y agoSo is that the TLDR of the article? /s
- ivape 1y agoHere's my regular Claude prompt: 5 bullet points, make sure I fully understand everything in 5 bullet points: (My deliberate buzzfeedification of the Internet) --- - Brain aging isn't linear - it follows an S-curve with key milestones: onset ~age 43, fastest decline ~age 61, then plateau. - Insulin resistance drives it - metabolic problems (high blood sugar) appear first in midlife, before vascular or inflammatory issues. - Neurons can't use glucose but could use ketones - gene analysis shows aging brain regions have high insulin-dependent transporters but also ketone transporters. - Ketones reverse aging effects, but only ages 40-60 - ketone supplements significantly helped younger/middle-aged brains but did nothing for 60+ year olds. - There's a critical intervention window - the 40s-50s appear to be when neurons are stressed but still saveable, suggesting early metabolic treatment could prevent dementia.
- xk_id 1y agoAgainst site rules to post generative text
- selcuka 1y agoWhere does it say that? Besides the GP clearly discloses that it is LLM-generated.
- ed 1y agoIt doesn’t. At least not in the guidelines or FAQ (links at the bottom of the site)
- falseprofit 1y agoIf it isn’t, it should be. No one asks in a forum because they want to hear from an LLM.
- _Algernon_ 1y agoThe article has an abstract. That is the tldr
- bethekidyouwant 1y ago“Ketones, whether produced endogenously through fasting or low-carbohydrate/high-fat diets or administered exogenously as a supplement, have been shown to improve age-related cognitive decline (23–25) and to restore insulin-resistance-induced deficits in axonal conduction velocity” - Another win for the gym bros
- dottjt 1y agoAs someone who has been weight lifting for the past few years and previously was really into keto diets, one thing I've realised is that carbs are simply necessary in order to have the energy to push very heavy weights. Fat just doesn't give you the required energy to do so. With that said, if you're only pushing moderately heavy weights or if you're a beginner and you're starting out with low weights, then it usually can be done. Though the compromise is usually to eat high carb/low fat on workout days, and low carb/high fat on rest days. Fasting as well helps a ton.
- nkozyra 1y agoCarbs are extremely helpful for strength, but there's a middle ground between ketosis and the standard American diet. Most who lift and do low carb time their carbs before and after workouts for specifically this reason. Some also do carbs before bed. But the rest of the day is close to no carbs. This still works. You can get < 100g of carbs a day and not have strength and energy negative impacts.
- dottjt 1y ago> Most who lift and do low carb time their carbs before and after workouts for specifically this reason. Some also do carbs before bed. This is exactly what I do. I have a have a pre-workout carb meal to try and compensate. Though one interesting thing I've noticed is that I've intentionally had to eat carbs as my body fat percentage has decreased. Otherwise I feel very low energy (though to be fair, I think part of it is that I'm still very active on my rest days, usually doing 20 - 30k steps). I think with higher body fat my body could simply burn that fat for energy, whereas that surplus simply isn't there.
- xeonmc 1y agoYou can also get ketones in nail polish removers.
- refulgentis 1y agoWell, yes, but not in a way that is particularly helpful. :) This isn't as funny or faddish or odd as it sounds at first blush. It's a well-recognized and effect help with epilepsy. My sister went on such a diet growing up and it helped. No more 20 minute seizures.
- ndesaulniers 1y ago[flagged]
- K0balt 1y agoFWIW I definitely noticed a downturn in my feeling of well being when I stopped huffing acetone.
- greesil 1y ago[flagged]
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- lherron 1y ago[flagged]
- jagaerglad 1y agoThe redditification of hacker news
- kirykl 1y agoDoing keto long enough however, your kidneys might wear out before your brain
- LPisGood 1y agoLive long enough and you turn to dust I guess.
- uoaei 1y agoJoni Ernst already proved just how unpopular this line of rhetoric can be.
- pstuart 1y agoIt's not the fact that we turn to dust -- we all understand that; but denying healthcare because you're gonna die anyway is messed up.
- throwcarsales 1y agoYou have to deny healthcare at a certain point because there will always be resources you could throw at someone to extend life span. Where do you stop? We already have the means to help people live longer than we do but don't do it for everyone because how are you going to pay for that at scale? Or do you mean you just want healthcare paid for at the level that you in particular believe it should be?
- uoaei 1y agoYou're not wrong. Ultimately the discussion boils down to whose values are we prioritizing by allocating society's resources. In the interest of supporting a culture of agency and self-determination the society should* be supporting the decisions of those most affected first. * I hate the word "should" but in this case we are already contextualized within an implied value system so it is used in a simple determinative manner.
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- casenmgreen 1y agoI'm not sure I understand the method. Is it correct that the study looked at the effect of a single (large) dose of ketones, rather than ongoing consumption? As I understand it, dosage was 0.395g per kilo of body weight (so about 27g for 70kg subject), and that was it - with measurements of brain activity before and after. No indication of duration of effect? I Googled and have found a product on Amazon, which is asking about 30 USD for that dose, which would make daily 900 USD a month (!)
- ImHereToVote 1y agoYou can make your own ketones by downing some MCT oil. Cheap AF. Just have to be somewhat fasted.
- casenmgreen 1y agoBeen looking into this. Looks like blood concentrations peak about 30 mins after ingestion, then back to normal after about 120 minutes. No info about how this relates to effects or duration of effects on cognition.
- anonzzzies 1y agoWhat are those supplements as I find a keto diet impossible to maintain.
- bionhoward 1y agoMCT oil could be one option because it’s a shorter chain saturated fat with a number of carbons divisible by 2, I forget the reason this is better for ketogenesis than longer chain triglycerides, Google answers didn’t seem like what I had learned about it. Avoiding high glycemic index carbs (sugar, dairy, starch) is a big factor. Also, water: beta oxidation of fat to make the ketones, is a hydrolysis reaction https://en.m.wikipedia.org/wiki/Ketogenesis https://en.m.wikipedia.org/wiki/Ketogenesis https://en.m.wikipedia.org/wiki/Beta_oxidation https://en.m.wikipedia.org/wiki/Beta_oxidation > Ketone bodies are not obligately produced from fatty acids; rather a meaningful amount of them is synthesized only in a situation of carbohydrate and protein insufficiency, where only fatty acids are readily available as fuel for their production.
- marstall 1y agothey used this product in the study - looks like subjects were geven about a 1/4-1/3 of the large bottle they sell, which is around $40 https://ketone.com https://ketone.com
- Kiyo-Lynn 1y agoI initially tried keto just to lose weight. But to my surprise, after about three weeks, I started feeling much clearer mentally, and overall just lighter, like something had lifted. Back then, I thought it was just a coincidence. Now, reading this paper, I’m starting to think it might really have something to do with how the brain gets its energy.
- jvanderbot 1y agoHave you heard of "Carb comas?" You're missing those now. And it's quite a relief.
- 1Sebastian 1y ago[dead]
- caleb-allen 1y agoOf note from the "Acknowledgements" section: > K.C. is a director of TdeltaS Ltd., a company spun out of the University of Oxford to develop products based on the science of ketone bodies in human nutrition.
- passwordoops 1y agoThought it looked too easy and clever just from the abstract
- stubish 1y agoSo, an specialist with ketones published a study related to ketones.
- reedf1 1y agoSo, a specialist with ketones published a study related to ketones; which they stand to benefit monetarily from.* That doesn't necessarily mean the research is suspect in itself - but there is a reason we need disclosures like this. "Competing interests: The intellectual property covering the manufacture and use of the ketone ester is owned by the University of Oxford and the NIH and is licensed to TdeltaS Global Inc. K.C., as an inventor, receives a share of the royalties under the terms prescribed by each institution. K.C. is a director of TdeltaS Ltd., a company spun out of the University of Oxford to develop products based on the science of ketone bodies in human nutrition."
- bonoboTP 1y agoOn the other hand, in the counterfactual case the reverse critique would also be possible: if he's so sure about his science claims, why doesn't he put his money where his mouth is?
- briansm 1y agoBit ironic when the path to ketosis is fasting (i.e. not using products).
- cmiller1 1y agoAbsolutely terrible science, the conclusion is a bunch of mechanistic speculation passed off as causal inference, just more keto bro grifters trying to pretend to be scientists.