3 ms·

The article doesn’t seem to posit one single cause, but anecdotally, the people in my family with dementia were women. One got it from smoking. Three others h

The article doesn’t seem to posit one single cause, but anecdotally, the people in my family with dementia were women. One got it from smoking. Three others had Alzheimer’s. The one who had it least bad was the one who had a job other than housewife

gwbas1c 1y ago
How do you get dementia from smoking?
- JumpCrisscross 1y ago
  "Smoking increases the risk of vascular problems (problems with the heart and blood vessels). These vascular problems are also linked to the two most common forms of dementia: Alzheimer's disease and vascular dementia. Toxins in cigarette smoke also cause inflammation and stress to cells, which have both been linked to Alzheimer's disease." https://www.alzheimers.org.uk/about-dementia/managing-the-risk-of-dementia/reduce-your-risk-of-dementia/smoking https://www.alzheimers.org.uk/about-dementia/managing-the-ri...
  - jjtheblunt 1y ago
    thanks for this link: they're interesting to mid 50s me, who never smoked, but whose dad did smoke for decades, and his memory started failing late 80s, i'd never seen it. useful link.
- toast0 1y ago
  I don't know how you determine causality of dementia. But smoking leads to poor heart and lung health and function, and that's got to have follow on effects on brain health. And there's correlation linking smoking to dementia [1]. So, I think it's fair to say grandma smokes a lot who had dementia got it from smoking even without a specific link. [1] https://www.heart.org/en/news/2021/07/06/smoking-harms-the-brain-raises-dementia-risk-but-not-if-you-quit https://www.heart.org/en/news/2021/07/06/smoking-harms-the-b...
- francisofascii 1y ago
  The vascular damage seems to be the main suspect. But I also wonder if smoking causes poor sleep due to it being a stimulant. Poor sleep leads to dementia.
vjvjvjvjghv 1y ago
In my family it’s the other way around. It’s very worrisome that both my father and grandfather had dementia.
- RyanOD 1y ago
  Same here. It's like a specter always one step behind me.
n1b0m 1y ago
“Women have a greater risk of developing dementia during their lifetime. The main reason for this is thought to be because women live longer than men. Age is the biggest risk factor for dementia so living longer means that the risk of developing it is greater.” https://www.alzheimers.org.uk/blog/why-dementia-different-women https://www.alzheimers.org.uk/blog/why-dementia-different-wo...
- matwood 1y ago
  Unfortunately my mom developed dementia in her late 60s. Not exactly old. I’ve wondered if covid triggered the onset. Her husband was/is a covid denier though he had it three times and almost died once. My mom never had a bad case of Covid, but was exposed many times.
pedalpete 1y ago
Women are twice as likely as men to get Alzheimer's. The two current prevailing theories are, both of which focus on the amyloid hypothesis are 1) menopause changes in grey matter reduce the glymphatic systems ability to flush metabolic waste from the brain 2) sleep loss during child-rearing and menopause result in increased amyloid load, which begins the cycle of reduced ability of the glymphatic system to remove waste from the brain. I know someone is going to come in complaining about the amyliod hypothesis, but it is unlikely to be "wrong", it is just incomplete. We are likely lumping multiple different diseases together under the label of Alzheimer's because we don't understand the disease well enough yet.
- missedthecue 1y ago
  Interestingly, research, including UK biobank data with massive sample sizes, has proven many times that childless women are at considerably higher risk for dementia and Alzheimer's than women with 1-4 children.
  - pedalpete 1y ago
    I hadn't seen that. I'll take a closer look. Thanks
- genewitch 1y ago
  Do you have anything that shows the link to sleep disorders and menopause? And if you happen to know, does that apply to artificial menopause, where the organs have been removed, and then you go through menopause directly afterward?
- Qem 1y ago
  > sleep loss during child-rearing and menopause The prevalence of obstructive sleep apnea is much larger in men than in women. If sleep loss were the only factor we probably would see greater dementia incidence in men, due to long-term chronic sleep loss from OSA.
math_dandy 1y ago
How was smoking identified as the cause’s of dementia in the individual you mention?
ZeroGravitas 1y ago
I've not seen air pollution mentioned yet. We've passed peak air pollution and generally research keeps revealing it to be worse than we thought for a variety of diseases you might not immediately link it to, like heart disease and stroke. Some of the research on gas stove pollution noticed an uptick in problems for women and linked it to them being closest to poorly operating kitchen burners (and burning food particles themselves might be a factor). https://ourworldindata.org/data-insights/the-world-has-probably-passed-peak-air-pollution https://ourworldindata.org/data-insights/the-world-has-proba... Glancing at the data for the US this seems to go the opposite direction, ramping to a peak in the 60-70s when I'd assume most damage in early years and/or working age. Though perhaps local and widespread air pollution are not following the same trajectory.
- DoingIsLearning 1y ago
  Not just air pollution at large but specifically we are practically sunsetting diesel engines in most developed urban centres. I can't find a quote but one trivia bit from 'diesel gate' is that the execs were aware of the neurotoxicity of NO2 and other substances that were found in higher concentration in diesel exhaust.
ramblerman 1y ago
one got it from smoking, and the other 2 got it from not smoking

gwbas1c 1y ago

How do you get dementia from smoking?

JumpCrisscross 1y ago
"Smoking increases the risk of vascular problems (problems with the heart and blood vessels). These vascular problems are also linked to the two most common forms of dementia: Alzheimer's disease and vascular dementia. Toxins in cigarette smoke also cause inflammation and stress to cells, which have both been linked to Alzheimer's disease." https://www.alzheimers.org.uk/about-dementia/managing-the-risk-of-dementia/reduce-your-risk-of-dementia/smoking https://www.alzheimers.org.uk/about-dementia/managing-the-ri...
- jjtheblunt 1y ago
  thanks for this link: they're interesting to mid 50s me, who never smoked, but whose dad did smoke for decades, and his memory started failing late 80s, i'd never seen it. useful link.
toast0 1y ago
I don't know how you determine causality of dementia. But smoking leads to poor heart and lung health and function, and that's got to have follow on effects on brain health. And there's correlation linking smoking to dementia [1]. So, I think it's fair to say grandma smokes a lot who had dementia got it from smoking even without a specific link. [1] https://www.heart.org/en/news/2021/07/06/smoking-harms-the-brain-raises-dementia-risk-but-not-if-you-quit https://www.heart.org/en/news/2021/07/06/smoking-harms-the-b...
francisofascii 1y ago
The vascular damage seems to be the main suspect. But I also wonder if smoking causes poor sleep due to it being a stimulant. Poor sleep leads to dementia.

vjvjvjvjghv 1y ago

In my family it’s the other way around. It’s very worrisome that both my father and grandfather had dementia.

RyanOD 1y ago
Same here. It's like a specter always one step behind me.

n1b0m 1y ago

“Women have a greater risk of developing dementia during their lifetime. The main reason for this is thought to be because women live longer than men. Age is the biggest risk factor for dementia so living longer means that the risk of developing it is greater.” https://www.alzheimers.org.uk/blog/why-dementia-different-women https://www.alzheimers.org.uk/blog/why-dementia-different-wo...

matwood 1y ago
Unfortunately my mom developed dementia in her late 60s. Not exactly old. I’ve wondered if covid triggered the onset. Her husband was/is a covid denier though he had it three times and almost died once. My mom never had a bad case of Covid, but was exposed many times.

pedalpete 1y ago

Women are twice as likely as men to get Alzheimer's. The two current prevailing theories are, both of which focus on the amyloid hypothesis are 1) menopause changes in grey matter reduce the glymphatic systems ability to flush metabolic waste from the brain 2) sleep loss during child-rearing and menopause result in increased amyloid load, which begins the cycle of reduced ability of the glymphatic system to remove waste from the brain. I know someone is going to come in complaining about the amyliod hypothesis, but it is unlikely to be "wrong", it is just incomplete. We are likely lumping multiple different diseases together under the label of Alzheimer's because we don't understand the disease well enough yet.

missedthecue 1y ago
Interestingly, research, including UK biobank data with massive sample sizes, has proven many times that childless women are at considerably higher risk for dementia and Alzheimer's than women with 1-4 children.
- pedalpete 1y ago
  I hadn't seen that. I'll take a closer look. Thanks
genewitch 1y ago
Do you have anything that shows the link to sleep disorders and menopause? And if you happen to know, does that apply to artificial menopause, where the organs have been removed, and then you go through menopause directly afterward?
Qem 1y ago
> sleep loss during child-rearing and menopause The prevalence of obstructive sleep apnea is much larger in men than in women. If sleep loss were the only factor we probably would see greater dementia incidence in men, due to long-term chronic sleep loss from OSA.

math_dandy 1y ago

How was smoking identified as the cause’s of dementia in the individual you mention?

ZeroGravitas 1y ago

I've not seen air pollution mentioned yet. We've passed peak air pollution and generally research keeps revealing it to be worse than we thought for a variety of diseases you might not immediately link it to, like heart disease and stroke. Some of the research on gas stove pollution noticed an uptick in problems for women and linked it to them being closest to poorly operating kitchen burners (and burning food particles themselves might be a factor). https://ourworldindata.org/data-insights/the-world-has-probably-passed-peak-air-pollution https://ourworldindata.org/data-insights/the-world-has-proba... Glancing at the data for the US this seems to go the opposite direction, ramping to a peak in the 60-70s when I'd assume most damage in early years and/or working age. Though perhaps local and widespread air pollution are not following the same trajectory.

DoingIsLearning 1y ago
Not just air pollution at large but specifically we are practically sunsetting diesel engines in most developed urban centres. I can't find a quote but one trivia bit from 'diesel gate' is that the execs were aware of the neurotoxicity of NO2 and other substances that were found in higher concentration in diesel exhaust.

ramblerman 1y ago

one got it from smoking, and the other 2 got it from not smoking