3 ms·
I'm a big fan of it in terms of efficacy; does wonders for headaches as well as joint aches. My concern is about the relatively recent findings about potential
by atombender 1y ago
I'm a big fan of it in terms of efficacy; does wonders for headaches as well as joint aches.
My concern is about the relatively recent findings about potential Alzheimer risk [1]:
> During a median follow-up of 12.3 years, 6407 (3.0%) participants developed new-onset all-cause dementia. Participants who regularly used paracetamol had a significantly higher risk of new-onset all-cause dementia (adjusted HR, 1.18; 95%CI: 1.10-1.26), compared with non-users. However, there was no significant association between regular use of ibuprofen and new-onset all-cause dementia (users vs. non-users; adjusted HR, 1.06; 95%CI: 0.97-1.16).
I don't follow the research closely enough to know if this is reliable evidence, but there are other studies showing the same thing.
Paracetamol also well known as mood-altering, apparently inhibiting empathy [2], which may be part of why it has an analgesic effect. That isn't as scary on a personal level, but imagine a society full of millions of people on paracetamol whose ability to feel empathy has been blunted.
[1] https://pubmed.ncbi.nlm.nih.gov/37633120/ https://pubmed.ncbi.nlm.nih.gov/37633120/
[2] https://pmc.ncbi.nlm.nih.gov/articles/PMC6455058/ https://pmc.ncbi.nlm.nih.gov/articles/PMC6455058/
- shawabawa3 1y agoI'm pretty sure ibuprofens risks are significantly higher than a 10-20% increased risk of dementia, it gives significantly increased risk of strokes iirc
- cma 1y agoI thought NSAIDs thinned blood more like apsirin and gave aneurysm risk instead of stroke, and the big risk was stomach bleeds.
- atombender 1y agoNSAIDs are COX inhibitors which inhibit either COX-1, COX-2, or both. COX-1 is involved in the gastric mucosa, among other roles, which is why blocking it can cause stomach bleeding. COX-2 is involved in maintaining the endothelium of blood vessels, and can increase stroke and infarction risk by stiffening and degrading the lining of the blood vessels over time. Studies are a bit conflicting regarding whether blocking COX-1 or COX-2 is safer, as there seems to be downsides to both, and the difference in risk isn't that clear.