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Do new liver cells always come from stem cells, not from dividing liver cells? Are those heppatocyte stem cells reside in the liver, or do they travel their via
by SubiculumCode 1y ago
Do new liver cells always come from stem cells, not from dividing liver cells? Are those heppatocyte stem cells reside in the liver, or do they travel their via migration,.or blood, etc?
A quick search suggests that liver regen involves dividing mature liver cells to replace turnover. If so, I'd suspect that they'd continue to carry the.crispr edit forward.
- dekhn 1y agoI believe new liver cells come from both dividing mature hepatocytes, and hepatocyte stem cells. Cells can only divide a limited number of times, and they can't easily re-differentiate, so I would expect that while dividing mature hepatocytes would propagate the edit, they would eventually be replaced by cells that derived from stem cells that didn't get the edit.