3 ms·

Any idea if this protein has any relation with seratonin? Could the effect of SSRIs be related in any way?

boredemployee 2y ago
in case anyone wondering: https://en.wikipedia.org/wiki/Selective_serotonin_reuptake_inhibitor https://en.wikipedia.org/wiki/Selective_serotonin_reuptake_i...
noncoml 2y ago
That’s a great question
xattt 2y ago
Isoniazid has an antidepressant effect as a weak MAOI, but any interaction with IL-17 would be indirect and related to a reduced microbial load in TB.
internet_rand0 2y ago
seratonin is a molecule this is a protein[1] this question strikes me as asking if a quark has a relation with an atom [1] https://en.wikipedia.org/wiki/Interleukin_17 https://en.wikipedia.org/wiki/Interleukin_17
- nartho 2y ago
  A protein is a molecule What a strange reply
  - deleted 2y ago
    [deleted]
  - jiggawatts 2y ago
    “Chemistry literacy” is very poor in the general public because it has very few everyday applications, so everything learnt at school just drops out of people’s brains. That’s why your hear nonsense like “It has chemicals in it!!!” It’s also why you regularly see science fiction where characters can grow in seconds, totally breaking the law of conservation of matter.
carabiner 2y ago
Serotonin has little relevance to depression and was more of a cute story doctors told patients in the '90s, that they were told by pharma reps.
- api 2y ago
  AFAIK the truth is a little more complex: SSRIs do work for many people, but we don't really understand why and it's not as simple as 'more serotonin good.' They also don't work for everyone, and we don't understand why they don't work for some people either.
dayvigo 2y ago
Serotonin can decrease IL-17 production, and IL-17 is highly elevated in depressed patients. Inflammation is elevated in depressed patients more generally, but baseline IL-17 levels specifically appear to be a good predictor for antidepressant response[1]. Anti-depressants are pretty much universally anti-neuroinflammatory. [1]: https://pubmed.ncbi.nlm.nih.gov/28698115/ https://pubmed.ncbi.nlm.nih.gov/28698115/
FollowingTheDao 2y ago
Yes, cytokine like IL 17 increase an enzyme called IDO which pulls tryptophan away from the serotonin production pathway. https://www.researchgate.net/figure/Effect-of-IDO-on-serotonin-metabolism-in-humans_fig7_339439877 https://www.researchgate.net/figure/Effect-of-IDO-on-seroton...

in case anyone wondering: https://en.wikipedia.org/wiki/Selective_serotonin_reuptake_inhibitor https://en.wikipedia.org/wiki/Selective_serotonin_reuptake_i...

noncoml 2y ago

That’s a great question

xattt 2y ago

Isoniazid has an antidepressant effect as a weak MAOI, but any interaction with IL-17 would be indirect and related to a reduced microbial load in TB.

internet_rand0 2y ago

seratonin is a molecule this is a protein[1] this question strikes me as asking if a quark has a relation with an atom [1] https://en.wikipedia.org/wiki/Interleukin_17 https://en.wikipedia.org/wiki/Interleukin_17

nartho 2y ago
A protein is a molecule What a strange reply
- deleted 2y ago
  [deleted]
- jiggawatts 2y ago
  “Chemistry literacy” is very poor in the general public because it has very few everyday applications, so everything learnt at school just drops out of people’s brains. That’s why your hear nonsense like “It has chemicals in it!!!” It’s also why you regularly see science fiction where characters can grow in seconds, totally breaking the law of conservation of matter.

carabiner 2y ago

Serotonin has little relevance to depression and was more of a cute story doctors told patients in the '90s, that they were told by pharma reps.

api 2y ago
AFAIK the truth is a little more complex: SSRIs do work for many people, but we don't really understand why and it's not as simple as 'more serotonin good.' They also don't work for everyone, and we don't understand why they don't work for some people either.

dayvigo 2y ago

Serotonin can decrease IL-17 production, and IL-17 is highly elevated in depressed patients. Inflammation is elevated in depressed patients more generally, but baseline IL-17 levels specifically appear to be a good predictor for antidepressant response[1]. Anti-depressants are pretty much universally anti-neuroinflammatory. [1]: https://pubmed.ncbi.nlm.nih.gov/28698115/ https://pubmed.ncbi.nlm.nih.gov/28698115/

FollowingTheDao 2y ago

Yes, cytokine like IL 17 increase an enzyme called IDO which pulls tryptophan away from the serotonin production pathway. https://www.researchgate.net/figure/Effect-of-IDO-on-serotonin-metabolism-in-humans_fig7_339439877 https://www.researchgate.net/figure/Effect-of-IDO-on-seroton...