3 ms·

>you need to catalog all the phages you find in a database and search for one that can target the specific bacteria the patient has been infected with. Most of

>you need to catalog all the phages you find in a database and search for one that can target the specific bacteria the patient has been infected with. Most of the time the doctor doesn't know the exact pathogen you are infected with. He'll suspect a bacterian infection of some kind and prescribe a wide range antibiotic. Doing what you suggest will require changing the way we do medicine. Which might not be a bad thing but requires some determination.

nomadpenguin 2y ago
This is correct, it's called empiric treatment. If a patient comes in with altered mental status and neck rigidity, you don't have time to take a lumbar puncture and culture bacteria. I don't know anything about phage treatment, but from what the other commenter said, it seems like then you'd have to do some sort of PCR test as well. You simply don't have time for any of that -- your only choice is to blast them with vancomycin + ceftriaxone.
- coryrc 2y ago
  Yeah, which is why we need to stop using antibiotics for cases where we could use phage treatment.
  - refulgentis 2y ago
    Wait what
    - coryrc 2y ago
      If you come into ED with GGP's symptom's, you might only have an hour to live. Hopefully for you it's bacterial and didn't pick up resistance from horizontal transference from a strep throat treatment that's trivial to culture and, while unpleasant, can wait a few hours to start treatment while the correct bacteriophage is readied.
ip26 2y ago
Feels like it might be more practical to simply distribute phage therapy to a whole population targeting a known pathogen, like this year’s cold strain. Especially of the goal is just to reduce the use of antibiotics, not eliminate.
- coryrc 2y ago
  "Common cold" is a virus. Vaccines train your immune system to fight things. Bacteriophages fight bacteria. They actually do the fighting. They are quickly cleared by the body, so they are useless for prevention.

nomadpenguin 2y ago

This is correct, it's called empiric treatment. If a patient comes in with altered mental status and neck rigidity, you don't have time to take a lumbar puncture and culture bacteria. I don't know anything about phage treatment, but from what the other commenter said, it seems like then you'd have to do some sort of PCR test as well. You simply don't have time for any of that -- your only choice is to blast them with vancomycin + ceftriaxone.

coryrc 2y ago
Yeah, which is why we need to stop using antibiotics for cases where we could use phage treatment.
- refulgentis 2y ago
  Wait what
  - coryrc 2y ago
    If you come into ED with GGP's symptom's, you might only have an hour to live. Hopefully for you it's bacterial and didn't pick up resistance from horizontal transference from a strep throat treatment that's trivial to culture and, while unpleasant, can wait a few hours to start treatment while the correct bacteriophage is readied.

ip26 2y ago

Feels like it might be more practical to simply distribute phage therapy to a whole population targeting a known pathogen, like this year’s cold strain. Especially of the goal is just to reduce the use of antibiotics, not eliminate.

coryrc 2y ago
"Common cold" is a virus. Vaccines train your immune system to fight things. Bacteriophages fight bacteria. They actually do the fighting. They are quickly cleared by the body, so they are useless for prevention.