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Gene dose increases in plants lead to bigger vegetables and fruiting bodies. We've taken advantage of this during domestication of several species. Gene dose i
by echelon 2y ago
Gene dose increases in plants lead to bigger vegetables and fruiting bodies. We've taken advantage of this during domestication of several species.
Gene dose increases in animals lead to total dysfunction and death in embryonic development.
- eimrine 2y agoDosis sola facit venenum?
- kjkjadksj 2y agoThere are species of fish that have gone through whole genome duplication. https://www.nature.com/articles/s41559-023-02299-z#:~:text=Polyploidy%20or%20whole%2Dgenome%20duplication,occurred%20during%20early%20vertebrate%20evolution. https://www.nature.com/articles/s41559-023-02299-z#:~:text=P...
- dekhn 2y agodose is such a weird term for "copies"
- flobosg 2y agoIt’s quite… historical.
- echelon 2y agohttps://en.wikipedia.org/wiki/Gene_dosage https://en.wikipedia.org/wiki/Gene_dosage Historical-sounding, maybe? It's still used in the literature: https://www.nature.com/articles/s41467-022-32144-z https://www.nature.com/articles/s41467-022-32144-z https://www.nature.com/articles/s41467-024-48960-4 https://www.nature.com/articles/s41467-024-48960-4 https://pmc.ncbi.nlm.nih.gov/articles/PMC10757140/ https://pmc.ncbi.nlm.nih.gov/articles/PMC10757140/
- dekhn 2y agoYeah, when I saw the original comment I tried to find the source of the term but wasn't able to find it. To me it sounds like medical genetics terminology (known for terms like "penetrance", "allele", "epistasis", "locus") whereas I'm a molecular biologist/biophysicist, which has far more precise ways of describing the underlying physical model.
- flobosg 2y agoA term can be still used in literature for historical reasons. Both concepts are not mutually exclusive.