5 ms·

It has happened in plants over and over again.

echelon 1y ago
Gene dose increases in plants lead to bigger vegetables and fruiting bodies. We've taken advantage of this during domestication of several species. Gene dose increases in animals lead to total dysfunction and death in embryonic development.
- eimrine 1y ago
  Dosis sola facit venenum?
- kjkjadksj 1y ago
  There are species of fish that have gone through whole genome duplication. https://www.nature.com/articles/s41559-023-02299-z#:~:text=Polyploidy%20or%20whole%2Dgenome%20duplication,occurred%20during%20early%20vertebrate%20evolution. https://www.nature.com/articles/s41559-023-02299-z#:~:text=P...
- dekhn 1y ago
  dose is such a weird term for "copies"
  - flobosg 1y ago
    It’s quite… historical.
    - echelon 1y ago
      https://en.wikipedia.org/wiki/Gene_dosage https://en.wikipedia.org/wiki/Gene_dosage Historical-sounding, maybe? It's still used in the literature: https://www.nature.com/articles/s41467-022-32144-z https://www.nature.com/articles/s41467-022-32144-z https://www.nature.com/articles/s41467-024-48960-4 https://www.nature.com/articles/s41467-024-48960-4 https://pmc.ncbi.nlm.nih.gov/articles/PMC10757140/ https://pmc.ncbi.nlm.nih.gov/articles/PMC10757140/
      - dekhn 1y ago
        Yeah, when I saw the original comment I tried to find the source of the term but wasn't able to find it. To me it sounds like medical genetics terminology (known for terms like "penetrance", "allele", "epistasis", "locus") whereas I'm a molecular biologist/biophysicist, which has far more precise ways of describing the underlying physical model.
      - flobosg 1y ago
        A term can be still used in literature for historical reasons. Both concepts are not mutually exclusive.
flobosg 1y ago
In bacteria as well!
kkylin 1y ago
And in yeast there has long been evidence for WGD. See, e.g., https://pmc.ncbi.nlm.nih.gov/articles/PMC4529243/ https://pmc.ncbi.nlm.nih.gov/articles/PMC4529243/ & references therein. Edit: I posted this without looking at the paper (which is about yeast). Doh.

Gene dose increases in plants lead to bigger vegetables and fruiting bodies. We've taken advantage of this during domestication of several species. Gene dose increases in animals lead to total dysfunction and death in embryonic development.

eimrine 1y ago
Dosis sola facit venenum?
kjkjadksj 1y ago
There are species of fish that have gone through whole genome duplication. https://www.nature.com/articles/s41559-023-02299-z#:~:text=Polyploidy%20or%20whole%2Dgenome%20duplication,occurred%20during%20early%20vertebrate%20evolution. https://www.nature.com/articles/s41559-023-02299-z#:~:text=P...
dekhn 1y ago
dose is such a weird term for "copies"
- flobosg 1y ago
  It’s quite… historical.
  - echelon 1y ago
    https://en.wikipedia.org/wiki/Gene_dosage https://en.wikipedia.org/wiki/Gene_dosage Historical-sounding, maybe? It's still used in the literature: https://www.nature.com/articles/s41467-022-32144-z https://www.nature.com/articles/s41467-022-32144-z https://www.nature.com/articles/s41467-024-48960-4 https://www.nature.com/articles/s41467-024-48960-4 https://pmc.ncbi.nlm.nih.gov/articles/PMC10757140/ https://pmc.ncbi.nlm.nih.gov/articles/PMC10757140/
    - dekhn 1y ago
      Yeah, when I saw the original comment I tried to find the source of the term but wasn't able to find it. To me it sounds like medical genetics terminology (known for terms like "penetrance", "allele", "epistasis", "locus") whereas I'm a molecular biologist/biophysicist, which has far more precise ways of describing the underlying physical model.
    - flobosg 1y ago
      A term can be still used in literature for historical reasons. Both concepts are not mutually exclusive.

flobosg 1y ago

In bacteria as well!

kkylin 1y ago

And in yeast there has long been evidence for WGD. See, e.g., https://pmc.ncbi.nlm.nih.gov/articles/PMC4529243/ https://pmc.ncbi.nlm.nih.gov/articles/PMC4529243/ & references therein. Edit: I posted this without looking at the paper (which is about yeast). Doh.