I'm a bit confused on whether "other models that may more reliably mimic human biology" generally exist today. The article mentions a couple non-animal models,

I'm a bit confused on whether "other models that may more reliably mimic human biology" generally exist today. The article mentions a couple non-animal models, but do we know that they are better analogues, or are they just ideas of where research might go if people didn't expect in vivo results? The point of in vivo studies, after all, is that it's easy to build artificial models which accidentally strip out some important complicating factor.