4 ms·

Okay, so the actual paper is here and about three months old: > https://www.mdpi.com/2076-3921/13/12/1549 https://www.mdpi.com/2076-3921/13/12/1549 The human

Okay, so the actual paper is here and about three months old: > https://www.mdpi.com/2076-3921/13/12/1549 https://www.mdpi.com/2076-3921/13/12/1549 The human equivalent dose of luteolin would be about 3g/day, which is a lot -- but this makes it more interesting, for although luteolin has been available as a nutritional supplement for decades, I don't think that people have normally taken it at that sort of dose. Or anywhere near that sort of dose. Luteolin is a weak yellow dye, but there are presumably ways to formulate it for topical use so that it's colorless. In general, it's usually pretty easy to get chemicals into follicles. (As opposed to through the skin, e.g. with a nicotine patch, which is possible but more difficult.) If this stuff works, it'll be a staple of haircare and anti-aging products for decades. It's not in that particular study, but more potent analogs appear to exist. They lack luteolin's easy off-the-shelf availability, though, and presumably the mechanism of action is the same at any rate.

TheSpiceIsLife 2y ago
> If this stuff works, it'll be a staple of haircare and anti-aging products for decades. You’re over thinking it. I tried Luteolin at clinically insignificant doses both as a nutritional supplement and in this really expensive hair care product and not only did it regrow my receding hair line, colour my hair unnaturally black, and marry someone half my age, if you buy one month supply right now at this exorbitant priced we’ll throw in a set of stake knives. IT REALLY WORKS!
cubefox 2y ago
Note also that you don't necessarily need to ingest it. Both internal and external treatment worked for the mice.
amelius 2y ago
What are the cofactors of this substance?
- A_D_E_P_T 2y ago
  Luteolin itself doesn't require cofactors as it is not enzymatic and the human body does not produce it. To humans, it's simply an exogenous small molecule... Like, e.g., aspirin. S-adenosylmethionine is presumably involved in its metabolism and excretion. This doesn't imply that you'd want to take SAMe with your luteolin dose.
amelius 2y ago
Before anyone gets too enthusiastic: https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2019.00041/full https://www.frontiersin.org/journals/molecular-neuroscience/... "The Dietary Flavonoid, Luteolin, Negatively Affects Neuronal Differentiation" Stem cells, but still ...
- A_D_E_P_T 2y ago
  There are a lot of issues with this study, but I'll start with the obvious one: They exposed those stem cells to a concentration of 15μM luteolin. That's grossly non-physiological. There's no way that you're ever going to see a 15µm plasma concentration following luteolin supplementation, at any reasonable dose. What's more: "Luteolin exhibits limited blood-brain barrier permeability (−0.907) and CNS permeability (−2.251), indicating poor penetration into the brain." > https://www.sciencedirect.com/science/article/pii/S2225411024000555 https://www.sciencedirect.com/science/article/pii/S222541102... So if 15µm concentrations are unattainable in plasma, the brain would be exposed to much less still. In animal experiments, as noted in your link, luteolin appears beneficial. There could be a dose-response-curve thing, where reasonable (physiological) amounts are neuroprotective, whereas exposing cells to very high concentrations directly is damaging.

TheSpiceIsLife 2y ago

> If this stuff works, it'll be a staple of haircare and anti-aging products for decades. You’re over thinking it. I tried Luteolin at clinically insignificant doses both as a nutritional supplement and in this really expensive hair care product and not only did it regrow my receding hair line, colour my hair unnaturally black, and marry someone half my age, if you buy one month supply right now at this exorbitant priced we’ll throw in a set of stake knives. IT REALLY WORKS!

cubefox 2y ago

Note also that you don't necessarily need to ingest it. Both internal and external treatment worked for the mice.

amelius 2y ago

What are the cofactors of this substance?

A_D_E_P_T 2y ago
Luteolin itself doesn't require cofactors as it is not enzymatic and the human body does not produce it. To humans, it's simply an exogenous small molecule... Like, e.g., aspirin. S-adenosylmethionine is presumably involved in its metabolism and excretion. This doesn't imply that you'd want to take SAMe with your luteolin dose.

amelius 2y ago

Before anyone gets too enthusiastic: https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2019.00041/full https://www.frontiersin.org/journals/molecular-neuroscience/... "The Dietary Flavonoid, Luteolin, Negatively Affects Neuronal Differentiation" Stem cells, but still ...

A_D_E_P_T 2y ago
There are a lot of issues with this study, but I'll start with the obvious one: They exposed those stem cells to a concentration of 15μM luteolin. That's grossly non-physiological. There's no way that you're ever going to see a 15µm plasma concentration following luteolin supplementation, at any reasonable dose. What's more: "Luteolin exhibits limited blood-brain barrier permeability (−0.907) and CNS permeability (−2.251), indicating poor penetration into the brain." > https://www.sciencedirect.com/science/article/pii/S2225411024000555 https://www.sciencedirect.com/science/article/pii/S222541102... So if 15µm concentrations are unattainable in plasma, the brain would be exposed to much less still. In animal experiments, as noted in your link, luteolin appears beneficial. There could be a dose-response-curve thing, where reasonable (physiological) amounts are neuroprotective, whereas exposing cells to very high concentrations directly is damaging.