4 ms·

Thanks for your personal empircal revelations. I'm sure you know Bupropion doesn't affect seratonin, its a dopamine re-uptake inhibitor. As someone who also d

Thanks for your personal empircal revelations. I'm sure you know Bupropion doesn't affect seratonin, its a dopamine re-uptake inhibitor. As someone who also doesn't seem to respond much to seratonin related meds, Burproprion worked somewhat but I suffer from increased insomnia as a side effect. I actually respond better to things mostly affecting GABA and NMDA rather than the 'classic' anti-depressents. That said I was trialled on methylphenidate and all it did was make me procrastinate waaaay faster, so personally I'm avoiding any stimulants stronger than caffeine.

arcticbull 2y ago
Bupropion is a noradrenaline and dopamine reuptake inhibitor, and a nicotinic receptor antagonist. You issues with sleep or probably due to the noradrenergic effect.
caycep 2y ago
bupropion does...a lot of things (including mildly doing what dextroamphetamine does...). A lot of these drugs don't just hit one receptor type...(don't get a pharmd started on receptor affinity binding profiles...)
- partomniscient 2y ago
  Fair call. So much of this stuff is simplified for us laypeople, but yeah - when you look up what so-and-so molecule does and find out how many different binding sites it interacts with as an agonist/antagonist/catlyst (and sometimes they've only measured interactions in rats) you realise there's a heck of a lot of stuff going on. I also got slightly weirded out when I found out something I was taking interacted with the mu-opiod receptors even though it wasn't an opiate.
  - mewpmewp2 2y ago
    Yeah, we have all these nice labels for all sorts of things, which makes it sound like everything is figured out, but this is definitely very far from the truth and complexity.
HalfCrimp 2y ago
I had similar insomnia issues with bupropion (which was otherwise greatly superior to SSRIs for me) until I started taking it immediately before going to sleep. I slept slightly shorter than usual, but woke up feeling great and had no issues getting to sleep.

arcticbull 2y ago

Bupropion is a noradrenaline and dopamine reuptake inhibitor, and a nicotinic receptor antagonist. You issues with sleep or probably due to the noradrenergic effect.

caycep 2y ago

bupropion does...a lot of things (including mildly doing what dextroamphetamine does...). A lot of these drugs don't just hit one receptor type...(don't get a pharmd started on receptor affinity binding profiles...)

partomniscient 2y ago
Fair call. So much of this stuff is simplified for us laypeople, but yeah - when you look up what so-and-so molecule does and find out how many different binding sites it interacts with as an agonist/antagonist/catlyst (and sometimes they've only measured interactions in rats) you realise there's a heck of a lot of stuff going on. I also got slightly weirded out when I found out something I was taking interacted with the mu-opiod receptors even though it wasn't an opiate.
- mewpmewp2 2y ago
  Yeah, we have all these nice labels for all sorts of things, which makes it sound like everything is figured out, but this is definitely very far from the truth and complexity.

HalfCrimp 2y ago

I had similar insomnia issues with bupropion (which was otherwise greatly superior to SSRIs for me) until I started taking it immediately before going to sleep. I slept slightly shorter than usual, but woke up feeling great and had no issues getting to sleep.