3 ms·
If Grail's Galleri is that great, why isn't it part of an annual checkup?
by Someone1234 2y ago
If Grail's Galleri is that great, why isn't it part of an annual checkup?
- raffraffraff 2y agoAnnual might not be any good. I knew a guy who had a history of colon cancer in his family. He got checked annually from his mid 30s on. At 46, a few months after a clear checkup, he visited his doctor who sent him for another check, and bam: he had cancer.
- nradov 2y agoIt's expensive, accuracy isn't very high, and no one has done the studies to demonstrate that it actually improves subject outcomes. By its very nature that type of research takes a long time because the investigators have to wait years to detect a difference in subject survival rates or other significant endpoints. There's a huge amount of funding going into the liquid biopsy space so things will improve. But don't expect rapid changes in clinical practice.
- qgin 2y agoNHS is evaluating it now in a trial. https://www.nhs-galleri.org https://www.nhs-galleri.org
- elektor 2y agoAn update on that trial: https://www.bmj.com/content/386/bmj.q1706 https://www.bmj.com/content/386/bmj.q1706 It doesn't look great.
- allpratik 2y agoAbsolutely right! This test is hyped. It has abysmally low sensitivity of 16% to detect stage I cancers and overall 44% for cancers of other stages. It is extremely poor sensitivity for any detection test.