5 ms·
Why eating less slows ageing: this molecule is key
- ghjfrdghibt 2y agoin flies and mice
- ExecutiveDre 2y ago3 meals a day + snacks don't make sense for the body but good for business.
- meiraleal 2y agoWaistline and GDP graphs growing together
- alfiedotwtf 2y ago”Breakfast is the most important meal of the day” — Advertising slogan, Kellogg’s 1917
- 2OEH8eoCRo0 2y agoThat slogan is an oversimplification but if I eat a bowl of steel cut at 7am I won't snack or be hungry until 2pm or later. Whether or not I eat this will have a strong impact on my day. Sounds important IMO
- aziaziazi 2y agoSteel Cut is non-whole oat cut in small bits for those wondering. I had to google, didn’t know if you were joking.
- herbst 2y agoI won't snack or am hungry before 17:00, usually not before 20:00 except I do sports or something, then I may need a snack around 14:00. If I do eat early my body takes hours to get to full energy again. It literally makes me tired. My girlfriend doesn't work that way. And I have no idea why this works so well for me.
- phil21 2y agoDepends on the person. If I eat breakfast I feel like crap for 2-3 hours afterwards. I have friends who can't function for the day before eating first. It's certainly not the most important meal of the day in general. Especially as a societal meme that came directly from an advertising campaign for a cereal manufacturer.
- sabbaticaldev 2y agoIf I don’t eat breakfast I won’t snack or be hungry until 5pm so the slogan isn’t a oversimplification, it’s marketing
- calebm 2y ago“Now, a team has found a molecule that could provide caloric restriction in a pill”… instead of just restricting calories
- drooby 2y agoWe need to have our cake and eat it too
- amelius 2y agoSpeaking of ageing, what happened with the research around this gene: https://pmc.ncbi.nlm.nih.gov/articles/PMC5403515/ https://pmc.ncbi.nlm.nih.gov/articles/PMC5403515/
- blakesterz 2y agoYou can see everything that has cited that so far here: https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=25832544 https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_cite... 154 so far. I'm not sure how to dig into that and answer the question though.
- bhargav 2y agoA lot of extensive research was done by Dr. Valter Longo and his department on similar topics and has made its way into an easily digestible book called The Longevity Diet. It changed my perspective big time with food. Highly recommend reading this book for folks that are interested in Longevity. Dr. Longo has also done a few podcasts with Dr. Rhonda Patrick (who might be more known to the audience here) you can checkout
- hasbot 2y agoThanks! I hadn't heard of The Longevity Diet. Here's a review: https://www.verywellhealth.com/the-longevity-diet-plan-overview-2223476 https://www.verywellhealth.com/the-longevity-diet-plan-overv... A summary of the diet from the review: The longevity diet resembles a modified vegan diet in which certain seafood and small amounts of meat and dairy are allowed. It is as much a lifestyle as an eating plan and can be followed for an indefinite amount of time. The guidelines include following a five-day fasting-mimicking diet periodically throughout the year.
- meiraleal 2y ago> The guidelines include following a five-day fasting-mimicking diet periodically throughout the year. Including real fasting in a diet beats any of those fad diets with fake fasting gimmicks.
- neogodless 2y agoWhat is "fasting-mimicking" and what are "fake fasting gimmicks"?
- meiraleal 2y agoFast-mimicking are diets where you eat but gets the same results as if fasting. Fake fasting gimmicks is the real name for this "diets" because you can't fake fasting with food.
- bhargav 2y ago
- lapcat 2y agoThe subtitle: > A naturally occurring compound involved in digestion lengthens lifespan in flies and makes old mice more youthful.
- shrx 2y agoThe molecule, called lithocholic acid, is made by bacteria in the gut and aids the digestion of fats.
- pama 2y agoIt is made by a relatively trivial change to CDCA (chenodeoxycholic acid), which in turn is made in the liver by cholesterol in a number of steps. I love the simplicity of stepwise modifications of complex molecules inside the body with the help of gut bacteria. True symbiosis.
- hasbot 2y agoThe title implies this works for humans but the article says "There is no evidence yet that taking lithocholic acid would have the same effect in humans."
- jilwoo 2y agoSlowing aging is over rated. Ask a farmer or a gardener. Just when you think you have worked out how to keep things alive and looking healthy, the universe will throw things at you (from a very long ever growing list) that can change the story overnight.
- byyoung3 2y agonah I think we can solve it
- hasbot 2y agoWhat would a farmer or a gardener have to say about slow aging?
- vizzah 2y agohow to keep something (a plant) alive and how unpredictable it can be
- Cpoll 2y agoFarmers and gardeners concern themselves with soil depletion and genetic diversity, so I'm not sure your point makes any sense.
- Qem 2y agoNow two questions popped in my head: 1 - Some non-statin antichilesterol drugs work by preventing reabsorption of bile acids, causing them to pass through the bowels. Can this have the positive side-effect of making lithocholic acid precursors more available to the gut flora downstream? See https://en.m.wikipedia.org/wiki/Bile_acid_sequestrant https://en.m.wikipedia.org/wiki/Bile_acid_sequestrant 2 - Does this affect those who underwent surgery to remove the gallbladder? Say, making caloric restriction more or less effective for this population.