3 ms·

This appears to be a simulation study done in 2d. Similar results have been observed in 2d simulations for more than 20 years, no one had managed to translate

This appears to be a simulation study done in 2d. Similar results have been observed in 2d simulations for more than 20 years, no one had managed to translate them to application. One of the problems is, that 2 d and 3d reaction-diffusion systems are very different when it comes to so-called topological charge conservation. One can show that interactions of the applied electrical field can be described by its influence on the topological charges. In 2d these topological charges are limited to points in 3d they form curves. Points are limited to drifting and colliding, lines can twist, self collide, form rings and so on making translating 1d results to 3d quite difficult.

KineticLensman 2y ago
> This appears to be a simulation study done in 2d. Yes. The paper says >> In this study, a simple two-dimensional numerical model of atrial tissue containing anatomical heterogeneities – the essential ingredient responsible for the emergence of virtual electrodes – was used to explore ultra-low-energy defibrillation. > no one had managed to translate them to application. Yes. The paper itself has the following statements in its conclusion: >> The approach considered here is impractical – it requires an accurate mathematical model of the tissue as well as complete knowledge of the state of the tissue at the initial time. Furthermore, computation of a defibrillating electrical field cannot be performed in real time.