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Tirzepatide and Semaglutide are both known to reduce addiction / substance ingestion. I noticed I was just less interested in Alcohol when I started on Wegovy,

Tirzepatide and Semaglutide are both known to reduce addiction / substance ingestion. I noticed I was just less interested in Alcohol when I started on Wegovy, and didn't realize it's a common effect until much later. I retained most of my disinterest after going off, too, FWIW.

dyauspitr 2y ago
Sounds like a miracle drug that helps with all afflictions that come with our modern life/sedentary living.
- rafaelmn 2y ago
  I'd say it's the opposite - if you don't exercise you end up skinny fat which is metabolically unhealthy as well. It helps with super accessible dopamine hits I guess - which is awesome - but need to combine it with exercise for maximum benefit. I wouldn't be surprised if they come up with a drug for that that's more sideffect free than testosterone/ derivatives. Lean and ripped cocktail
  - jjeaff 2y ago
    Skinny fat is not nearly as metabolically unhealthy as fat fat.
    - rafaelmn 2y ago
      No argument here - just saying it's still not the endgame. Lean/ripped combo - now that's something I'd subscribe to/inject for regularly.
    - queuebert 2y ago
      Fat fat can better survive the coming post-AGI apocalyptic famines.
      - wwweston 2y ago
        Turns out it can also be useful during a personal apocalypse: having recently lost about 35lbs from emergency chest-cracking surgery, ended up pretty glad I wasn't at my leanest going into it (sadly, more of the weight lost was probably muscle wasting/deconditioning than fat stores, but on balance it was probably good I had at least 15lbs of fat stores to burn).
    - azinman2 2y ago
      It’s actually worse in terms of metabolic disease, surprisingly. https://www.mayoclinic.org/diseases-conditions/metabolic-syndrome/multimedia/apple-and-pear-body-shapes/img-20006114#:~:text=People%20who%20have%20metabolic%20syndrome,of%20weight%20around%20their%20abdomens https://www.mayoclinic.org/diseases-conditions/metabolic-syn....
  - vessenes 2y ago
    This is true, but I'd qualify it. I'm MUCH more active than when I started, just naturally, and my heart health / true age stats (for what they're worth) are twenty years lower than when I started. I lost a lot of muscle, but as a percentage, my body fat is nearly half what it was when I started. 10/10 would do again. Recomping is a huge struggle, you just can't eat enough to add muscle bulk. Cycling on and off is tough because if you don't taper off it, your body is like "thanks for ending that long term caloric deficit, have you heard of cake?". So you definitely need to approach the muscle mass question seriously, but in no world was I healthier back when I had an extra 10 to 20lbs of muscle, and the rest in fat.
    - vladgur 2y ago
      Would you mind sharing before and after lean/fat percentages and or numbers? I am really curious if there is a way to optimize bulkng prior to getting on these drugs with a goal of retaining muscle mass(important as we age)
      - vessenes 2y ago
        Prefer not -- sorry! I'm here on my real name. If you want my advice, lose the weight then worry about it. A good amount of research indicates you tend to gain muscle mass in the fat/muscle percentage you start with; regardless if you are seriously in need of weight loss, the benefits of doing that far outweigh the (temporary?) downsides of losing some muscle mass for most people I bet.
        vladgur 2y ago
        Totally understood. I do hear amazing results from people whose BMI is 35 or above. I wonder how well it works for people with Normal to Overweight BMI of about 25 to 35
        vessenes 2y ago
        I went from BMI 38 to 24. It worked fastest in the mid ranges.
- marcosdumay 2y ago
  Except for all the externally imposed ones. But yes, there's a reason people are celebrating those drugs.
- Alupis 2y ago
  The problem with this (and all diet plans/drugs) is the lifestyle that led to problem in the first place. If you do not change your lifestyle, for real and not just superficially, then you will relapse with a vengeance. That is to say, be careful with using a drug as a crutch. Sure, it can artificially make you much more interested in not consuming so many calories and/or perhaps being more active than before - but you have to continue that lifestyle after stopping the drug. Will Ozempic users have developed the personal discipline to prevent themselves from relapse without the drug - or will they forever be on a the yo-yo of weight gain/loss?
  - JamesBarney 2y ago
    >If you do not change your lifestyle, for real and not just superficially, then you will relapse with a vengeance. Longterm glp-1 agonist research doesn't agree with this. > but you have to continue that lifestyle after stopping the drug. Why stop the drug? >Will Ozempic users have developed the personal discipline to prevent themselves from relapse without the drug - or will they forever be on a the yo-yo of weight gain/loss? A small % of people are able to achieve significant weight loss with diet and exercise. And an even smaller % of that group are able to maintain it for the long term. We've been trying to solve obesity this way for a 50 years and have bubkis to show for it. If someone has high cholesterol we give them a statin, if they have high blood sugar we give them diabetes. Now if they're overweight we give them ozempic.
    - Alupis 2y ago
      > Why stop the drug? Why would you want to continue using a drug for the rest of your life? > Longterm glp-1 agonist research doesn't agree with this. Please explain. If you stop using the drug, because you've achieved your goals, what stops you from relapsing other than your own personal habits and lifestyle? > A small % of people are able to achieve significant weight loss with diet and exercise. And an even smaller % of that group are able to maintain it for the long term. We've been trying to solve obesity this way for a 50 years and have bubkis to show for it. If someone has high cholesterol we give them a statin, if they have high blood sugar we give them diabetes. Now if they're overweight we give them ozempic. Yes, a pill for this, a pill for that... and there's no chance we'll discover these drugs have negative effects when used by a person for 50 years.
- arijo 2y ago
  It's not a miracle drug. Check this Joe Rogan interview to understand at a deep level all the problems with a drug like Ozempic: https://www.youtube.com/watch?v=G0lTyhvOeJs https://www.youtube.com/watch?v=G0lTyhvOeJs
  - karmajunkie 2y ago
    you lost the debate the moment you cite joe rogan.
    - arijo 2y ago
      I would listen to what his guests on this particular podcast have to say before jumping into conclusions just because the interviewer is Joe Rogan. I have no particular opinion on him - I’m just interested in what the interviewees in this specific episode have to say about metabolic health which has direct implications on the massive usage of drugs like ozempic.
      - cthalupa 2y ago
        I'll start with stating that Joe Rogan has, as the years have gone on, resulted to more and more fringe guests on basically every subject. Then I'll point out that these guests are MDs, not PhDs. And then I'll point out this bit from the description: > Dr. Casey Means is the Co-Founder of Levels Health, which provides insights into metabolic health through real-time data. Calley Means is the Co-Founder of Truemed, which enables HSA spending on healthy food, supplements and exercise. They are the co-authors of "Good Energy." Their livelihood is based on selling people apps, services, hardware, supplements, etc. around a certain lifestyle. They've got direct financial incentive to be against GLP1 medications. For any specific claims, well, if you're going to use a video for reference, present the specific claims, timestamps, etc. You can't expect random people on the internet to watch a two and a half hour video off of nothing more than "you'll understand at a deep level the problem with glp1 drugs!"
        arijo 2y ago
- eli_gottlieb 2y ago
  Honestly, sounds like our "modern lifestyle" is designed to get everyone addicted to something, and the healthiest possible addiction is, as it turns out, an anti-addiction medication.
asyx 2y ago
I take mounjaro because I have T2 diabetes and it is a lot easier to stick to a diabetes appropriate diet. I was already normal weight and I lost 50kg 10 years ago but I could never really eat cleanly even after losing all that weight. The diabetes only improved that slightly. Now, I can easily stick to a super low carb diet

dyauspitr 2y ago

Sounds like a miracle drug that helps with all afflictions that come with our modern life/sedentary living.

rafaelmn 2y ago
I'd say it's the opposite - if you don't exercise you end up skinny fat which is metabolically unhealthy as well. It helps with super accessible dopamine hits I guess - which is awesome - but need to combine it with exercise for maximum benefit. I wouldn't be surprised if they come up with a drug for that that's more sideffect free than testosterone/ derivatives. Lean and ripped cocktail
- jjeaff 2y ago
  Skinny fat is not nearly as metabolically unhealthy as fat fat.
  - rafaelmn 2y ago
    No argument here - just saying it's still not the endgame. Lean/ripped combo - now that's something I'd subscribe to/inject for regularly.
  - queuebert 2y ago
    Fat fat can better survive the coming post-AGI apocalyptic famines.
    - wwweston 2y ago
      Turns out it can also be useful during a personal apocalypse: having recently lost about 35lbs from emergency chest-cracking surgery, ended up pretty glad I wasn't at my leanest going into it (sadly, more of the weight lost was probably muscle wasting/deconditioning than fat stores, but on balance it was probably good I had at least 15lbs of fat stores to burn).
  - azinman2 2y ago
    It’s actually worse in terms of metabolic disease, surprisingly. https://www.mayoclinic.org/diseases-conditions/metabolic-syndrome/multimedia/apple-and-pear-body-shapes/img-20006114#:~:text=People%20who%20have%20metabolic%20syndrome,of%20weight%20around%20their%20abdomens https://www.mayoclinic.org/diseases-conditions/metabolic-syn....
- vessenes 2y ago
  This is true, but I'd qualify it. I'm MUCH more active than when I started, just naturally, and my heart health / true age stats (for what they're worth) are twenty years lower than when I started. I lost a lot of muscle, but as a percentage, my body fat is nearly half what it was when I started. 10/10 would do again. Recomping is a huge struggle, you just can't eat enough to add muscle bulk. Cycling on and off is tough because if you don't taper off it, your body is like "thanks for ending that long term caloric deficit, have you heard of cake?". So you definitely need to approach the muscle mass question seriously, but in no world was I healthier back when I had an extra 10 to 20lbs of muscle, and the rest in fat.
  - vladgur 2y ago
    Would you mind sharing before and after lean/fat percentages and or numbers? I am really curious if there is a way to optimize bulkng prior to getting on these drugs with a goal of retaining muscle mass(important as we age)
    - vessenes 2y ago
      Prefer not -- sorry! I'm here on my real name. If you want my advice, lose the weight then worry about it. A good amount of research indicates you tend to gain muscle mass in the fat/muscle percentage you start with; regardless if you are seriously in need of weight loss, the benefits of doing that far outweigh the (temporary?) downsides of losing some muscle mass for most people I bet.
      - vladgur 2y ago
        Totally understood. I do hear amazing results from people whose BMI is 35 or above. I wonder how well it works for people with Normal to Overweight BMI of about 25 to 35
        vessenes 2y ago
        I went from BMI 38 to 24. It worked fastest in the mid ranges.
marcosdumay 2y ago
Except for all the externally imposed ones. But yes, there's a reason people are celebrating those drugs.
Alupis 2y ago
The problem with this (and all diet plans/drugs) is the lifestyle that led to problem in the first place. If you do not change your lifestyle, for real and not just superficially, then you will relapse with a vengeance. That is to say, be careful with using a drug as a crutch. Sure, it can artificially make you much more interested in not consuming so many calories and/or perhaps being more active than before - but you have to continue that lifestyle after stopping the drug. Will Ozempic users have developed the personal discipline to prevent themselves from relapse without the drug - or will they forever be on a the yo-yo of weight gain/loss?
- JamesBarney 2y ago
  >If you do not change your lifestyle, for real and not just superficially, then you will relapse with a vengeance. Longterm glp-1 agonist research doesn't agree with this. > but you have to continue that lifestyle after stopping the drug. Why stop the drug? >Will Ozempic users have developed the personal discipline to prevent themselves from relapse without the drug - or will they forever be on a the yo-yo of weight gain/loss? A small % of people are able to achieve significant weight loss with diet and exercise. And an even smaller % of that group are able to maintain it for the long term. We've been trying to solve obesity this way for a 50 years and have bubkis to show for it. If someone has high cholesterol we give them a statin, if they have high blood sugar we give them diabetes. Now if they're overweight we give them ozempic.
  - Alupis 2y ago
    > Why stop the drug? Why would you want to continue using a drug for the rest of your life? > Longterm glp-1 agonist research doesn't agree with this. Please explain. If you stop using the drug, because you've achieved your goals, what stops you from relapsing other than your own personal habits and lifestyle? > A small % of people are able to achieve significant weight loss with diet and exercise. And an even smaller % of that group are able to maintain it for the long term. We've been trying to solve obesity this way for a 50 years and have bubkis to show for it. If someone has high cholesterol we give them a statin, if they have high blood sugar we give them diabetes. Now if they're overweight we give them ozempic. Yes, a pill for this, a pill for that... and there's no chance we'll discover these drugs have negative effects when used by a person for 50 years.
arijo 2y ago
It's not a miracle drug. Check this Joe Rogan interview to understand at a deep level all the problems with a drug like Ozempic: https://www.youtube.com/watch?v=G0lTyhvOeJs https://www.youtube.com/watch?v=G0lTyhvOeJs
- karmajunkie 2y ago
  you lost the debate the moment you cite joe rogan.
  - arijo 2y ago
    I would listen to what his guests on this particular podcast have to say before jumping into conclusions just because the interviewer is Joe Rogan. I have no particular opinion on him - I’m just interested in what the interviewees in this specific episode have to say about metabolic health which has direct implications on the massive usage of drugs like ozempic.
    - cthalupa 2y ago
      I'll start with stating that Joe Rogan has, as the years have gone on, resulted to more and more fringe guests on basically every subject. Then I'll point out that these guests are MDs, not PhDs. And then I'll point out this bit from the description: > Dr. Casey Means is the Co-Founder of Levels Health, which provides insights into metabolic health through real-time data. Calley Means is the Co-Founder of Truemed, which enables HSA spending on healthy food, supplements and exercise. They are the co-authors of "Good Energy." Their livelihood is based on selling people apps, services, hardware, supplements, etc. around a certain lifestyle. They've got direct financial incentive to be against GLP1 medications. For any specific claims, well, if you're going to use a video for reference, present the specific claims, timestamps, etc. You can't expect random people on the internet to watch a two and a half hour video off of nothing more than "you'll understand at a deep level the problem with glp1 drugs!"
      - arijo 2y ago
eli_gottlieb 2y ago
Honestly, sounds like our "modern lifestyle" is designed to get everyone addicted to something, and the healthiest possible addiction is, as it turns out, an anti-addiction medication.

asyx 2y ago

I take mounjaro because I have T2 diabetes and it is a lot easier to stick to a diabetes appropriate diet. I was already normal weight and I lost 50kg 10 years ago but I could never really eat cleanly even after losing all that weight. The diabetes only improved that slightly. Now, I can easily stick to a super low carb diet