The models and tools designed for the CASP competition were an example of running around the solution space at a glacial pace and getting stuck in local minima.

The models and tools designed for the CASP competition were an example of running around the solution space at a glacial pace and getting stuck in local minima. I can't speak for Rosetta by my labmates had fairly successful tools that usually ranked right behind Baker's lab, and they were plagued by issues where the most successful models had impossible or idiosyncratic terms in them. For example, a very successful folding model had the signs reversed on hydrophobic and some electrostatic interactions. It made no sense physically but it gave a better prediction than competing models, and it was hard to move away from because it ranked well in CASP.