4 ms·

Which human? Despite large sections shared by all mankind and even other species, each individual has an unique genome, except identical twins.

by Qem 2y ago

dekhn 2y ago
I was unable to find a scientific article explaining the data source in detail. Likely, they uploaded the reference genome.
0cf8612b2e1e 2y ago
It is worse than that. There is drift within an organism. The genome on your scalp is different than the genome on your toes. https://dx.doi.org/10.1126/science.aaw0726 https://dx.doi.org/10.1126/science.aaw0726
- LoganDark 2y ago
  Also chimeras exist (even natural ones)
  - acchow 2y ago
    > There is drift within an organism. The genome on your scalp is different than the genome on your toes > Also chimeras exist This provides a deep insight into the nature of multicellular life. People think that a "unicellular organism" eventually turned into a "multicellular organism". But they're not so distinct. The latter is really still just a bunch of cells coordinating, but their coordination is so deep, and the number of cells and functions so large, that emergent properties arise.
- charlieo88 2y ago
  Worse than that, by count, only a minority of the cells using a person's DNA make up that person. The number of other cells are 10x, but being smaller, only make up 1% to 3% by mass. https://www.nih.gov/news-events/news-releases/nih-human-microbiome-project-defines-normal-bacterial-makeup-body https://www.nih.gov/news-events/news-releases/nih-human-micr...
dekhn 2y ago
any human differs less than 1 % (although it really depends on how you count differences). It would make sense to store one reference, and then everybody is stored as a delta relative to that (https://en.wikipedia.org/wiki/CRAM_(file_format) https://en.wikipedia.org/wiki/CRAM_(file_format) and https://en.wikipedia.org/wiki/Compression_of_genomic_sequencing_data https://en.wikipedia.org/wiki/Compression_of_genomic_sequenc...)

Which human? Despite large sections shared by all mankind and even other species, each individual has an unique genome, except identical twins.

by Qem 2y ago

Which human? Despite large sections shared by all mankind and even other species, each individual has an unique genome, except identical twins.

dekhn 2y ago

I was unable to find a scientific article explaining the data source in detail. Likely, they uploaded the reference genome.

0cf8612b2e1e 2y ago

It is worse than that. There is drift within an organism. The genome on your scalp is different than the genome on your toes. https://dx.doi.org/10.1126/science.aaw0726 https://dx.doi.org/10.1126/science.aaw0726

LoganDark 2y ago
Also chimeras exist (even natural ones)
- acchow 2y ago
  > There is drift within an organism. The genome on your scalp is different than the genome on your toes > Also chimeras exist This provides a deep insight into the nature of multicellular life. People think that a "unicellular organism" eventually turned into a "multicellular organism". But they're not so distinct. The latter is really still just a bunch of cells coordinating, but their coordination is so deep, and the number of cells and functions so large, that emergent properties arise.
charlieo88 2y ago
Worse than that, by count, only a minority of the cells using a person's DNA make up that person. The number of other cells are 10x, but being smaller, only make up 1% to 3% by mass. https://www.nih.gov/news-events/news-releases/nih-human-microbiome-project-defines-normal-bacterial-makeup-body https://www.nih.gov/news-events/news-releases/nih-human-micr...

dekhn 2y ago

any human differs less than 1 % (although it really depends on how you count differences). It would make sense to store one reference, and then everybody is stored as a delta relative to that (https://en.wikipedia.org/wiki/CRAM_(file_format) https://en.wikipedia.org/wiki/CRAM_(file_format) and https://en.wikipedia.org/wiki/Compression_of_genomic_sequencing_data https://en.wikipedia.org/wiki/Compression_of_genomic_sequenc...)