4 ms·

It actually blows my mind how long this went on without any medical practitioners suspecting poisoning. The inexplicable vitamin D coming out of apparently now

It actually blows my mind how long this went on without any medical practitioners suspecting poisoning. The inexplicable vitamin D coming out of apparently nowhere? He had amounts in him that are basically impossible to have by any diet. I'm glad the culprit was "caught", but wow.

A_D_E_P_T 2y ago
They suspected that he was taking the Vitamin D himself, as though he had Munchausen Syndrome. Hence the note about "the dramatic course of care." Poisoning with VD3 is objectively weird. It's not very effective. If she had used tetrahydrozoline eyedrops, he'd be a goner after one dose -- and, with his heart and electrolyte balance troubles, odds are that nobody would be the wiser. We therefore have to surmise that she didn't want to kill him, but wanted to keep him sick, reliant, and compliant.
- cracadumi 2y ago
  In this case it's weird that she didn't want to call the ambulance when he "almost died"
  - kruxigt 2y ago
    [dead]
- Rodmine 2y ago
  [flagged]
- pureheartlover 2y ago
  This is such an irresponsible post to make.
- hyeonwho4 2y ago
  In another post, he states that the 960 mg/l of calcium was found in his water. That would be enough to cause hypercalcemia if drinking 3 l per day, let alone 6 l.
- seszett 2y ago
  > Poisoning with VD3 is objectively weird. It's not very effective But they have small children, which are supposed to take vitamin D supplement that comes in this kind of bottle. So it's both easy for her and probably easier to explain, however vitamin D comes in an oil suspension, not water, so it seems to me that it wouldn't mix well in water. She could have put potassium in his water and vitamin D in oil and food. That seems more likely to me. Edit come to think of it, they did find elevated vitamin D levels in the water so I guess it was somehow a water-soluble formula. Not sure why she mentioned potassium then.
Ey7NFZ3P0nzAe 2y ago
It's because he was diagnosed before with sarcoidosis. It can have an impact on both vitamin D and calcium. Which is plausibly why she tried using those agents to poison him: instead of being suspicious it was seen as a very complicated medical case. Here's what I asked sonnet for a friend: --- Here's an ASCII diagram illustrating the relationship: Sarcoidosis | v Granulomas | v 1-alpha-hydroxylase ↑ | v 25(OH)D ---------> 1,25(OH)2D ↑ ^ | | v Vitamin D3 <-------- Calcium absorption ↑ | v Serum Calcium ↑ | v Hypercalcemia Explanation for a 3rd-year medical student: - Sarcoidosis is a granulomatous disease characterized by the formation of granulomas in various organs, particularly the lungs. - These granulomas contain activated macrophages that express high levels of 1-alpha-hydroxylase, the enzyme responsible for converting 25-hydroxyvitamin D (25(OH)D) to its active form, 1,25-dihydroxyvitamin D (1,25(OH)2D). - The increased 1-alpha-hydroxylase activity leads to excessive production of 1,25(OH)2D, which is not regulated by the normal feedback mechanisms. - 1,25(OH)2D enhances intestinal calcium absorption and bone resorption, leading to increased serum calcium levels. - This process can result in hypercalcemia, a common complication in sarcoidosis patients. - The excess 1,25(OH)2D also suppresses parathyroid hormone (PTH) production, which normally regulates calcium homeostasis. - Importantly, the increased 1,25(OH)2D levels are not dependent on vitamin D intake or sun exposure, as the conversion occurs independently of the body's vitamin D status. - This dysregulation can lead to a paradoxical situation where patients with sarcoidosis may have high 1,25(OH)2D levels but low or normal 25(OH)D levels. Key points to remember: - Granulomas in sarcoidosis are the source of increased 1-alpha-hydroxylase activity. - This leads to excessive 1,25(OH)2D production, independent of normal regulatory mechanisms. - The result is increased calcium absorption and potential hypercalcemia. - Management often involves limiting calcium and vitamin D intake, and in some cases, using corticosteroids to suppress granuloma activity.

A_D_E_P_T 2y ago

They suspected that he was taking the Vitamin D himself, as though he had Munchausen Syndrome. Hence the note about "the dramatic course of care." Poisoning with VD3 is objectively weird. It's not very effective. If she had used tetrahydrozoline eyedrops, he'd be a goner after one dose -- and, with his heart and electrolyte balance troubles, odds are that nobody would be the wiser. We therefore have to surmise that she didn't want to kill him, but wanted to keep him sick, reliant, and compliant.

cracadumi 2y ago
In this case it's weird that she didn't want to call the ambulance when he "almost died"
- kruxigt 2y ago
  [dead]
Rodmine 2y ago
[flagged]
pureheartlover 2y ago
This is such an irresponsible post to make.
hyeonwho4 2y ago
In another post, he states that the 960 mg/l of calcium was found in his water. That would be enough to cause hypercalcemia if drinking 3 l per day, let alone 6 l.
seszett 2y ago
> Poisoning with VD3 is objectively weird. It's not very effective But they have small children, which are supposed to take vitamin D supplement that comes in this kind of bottle. So it's both easy for her and probably easier to explain, however vitamin D comes in an oil suspension, not water, so it seems to me that it wouldn't mix well in water. She could have put potassium in his water and vitamin D in oil and food. That seems more likely to me. Edit come to think of it, they did find elevated vitamin D levels in the water so I guess it was somehow a water-soluble formula. Not sure why she mentioned potassium then.

Ey7NFZ3P0nzAe 2y ago

It's because he was diagnosed before with sarcoidosis. It can have an impact on both vitamin D and calcium. Which is plausibly why she tried using those agents to poison him: instead of being suspicious it was seen as a very complicated medical case. Here's what I asked sonnet for a friend: --- Here's an ASCII diagram illustrating the relationship: Sarcoidosis | v Granulomas | v 1-alpha-hydroxylase ↑ | v 25(OH)D ---------> 1,25(OH)2D ↑ ^ | | v Vitamin D3 <-------- Calcium absorption ↑ | v Serum Calcium ↑ | v Hypercalcemia Explanation for a 3rd-year medical student: - Sarcoidosis is a granulomatous disease characterized by the formation of granulomas in various organs, particularly the lungs. - These granulomas contain activated macrophages that express high levels of 1-alpha-hydroxylase, the enzyme responsible for converting 25-hydroxyvitamin D (25(OH)D) to its active form, 1,25-dihydroxyvitamin D (1,25(OH)2D). - The increased 1-alpha-hydroxylase activity leads to excessive production of 1,25(OH)2D, which is not regulated by the normal feedback mechanisms. - 1,25(OH)2D enhances intestinal calcium absorption and bone resorption, leading to increased serum calcium levels. - This process can result in hypercalcemia, a common complication in sarcoidosis patients. - The excess 1,25(OH)2D also suppresses parathyroid hormone (PTH) production, which normally regulates calcium homeostasis. - Importantly, the increased 1,25(OH)2D levels are not dependent on vitamin D intake or sun exposure, as the conversion occurs independently of the body's vitamin D status. - This dysregulation can lead to a paradoxical situation where patients with sarcoidosis may have high 1,25(OH)2D levels but low or normal 25(OH)D levels. Key points to remember: - Granulomas in sarcoidosis are the source of increased 1-alpha-hydroxylase activity. - This leads to excessive 1,25(OH)2D production, independent of normal regulatory mechanisms. - The result is increased calcium absorption and potential hypercalcemia. - Management often involves limiting calcium and vitamin D intake, and in some cases, using corticosteroids to suppress granuloma activity.