Not according to Novo Nordisk. https://www.bbc.com/future/article/20240521-what-happens-when-you-stop-taking-ozempic https://www.bbc.com/future/article/2024052

Not according to Novo Nordisk. https://www.bbc.com/future/article/20240521-what-happens-when-you-stop-taking-ozempic https://www.bbc.com/future/article/20240521-what-happens-whe... The same trend was seen after the 2021 trial, known as Step 1. After 68 weeks of semaglutide injections, the average patient lost more than 15% of their body weight, but within 12 months of treatment ending, patients regained two thirds of their prior weight loss on average. This was associated with a similar level of reversion to the patients' original baselines in some markers of their cardiometabolic health – a category which includes conditions such as diabetes and heart attacks. Both Rubino and other experts around the world have seen similar patterns when administering GLP-1 drugs in their clinics. "There will be a small proportion of people, 10% maximum, that are able to maintain [all] the weight they've lost," says Alex Miras, a clinical professor of medicine at Ulster University.