5 ms·

Why is this an "instead"? We already know that people on semaglutides buy less junk food because to them it is less addictive. Less demand, less supply. If any

Why is this an "instead"? We already know that people on semaglutides buy less junk food because to them it is less addictive. Less demand, less supply. If anything, this seems like a useful way to smooth the transition to less unhealthy food supply.

alamortsubite 2y ago
People are effectively on these medications permanently or they regain whatever weight they lost on them. So unfortunately the transition isn't so much to healthier diets, but to taking weight-loss drugs forever.
- orwin 2y ago
  Is this true? Is the rebound effect as high as you think? Because I know 2 people who took it for like 3 years, and while they took some weight back, they're not obese anymore.
  - alamortsubite 2y ago
    Not according to Novo Nordisk. https://www.bbc.com/future/article/20240521-what-happens-when-you-stop-taking-ozempic https://www.bbc.com/future/article/20240521-what-happens-whe... The same trend was seen after the 2021 trial, known as Step 1. After 68 weeks of semaglutide injections, the average patient lost more than 15% of their body weight, but within 12 months of treatment ending, patients regained two thirds of their prior weight loss on average. This was associated with a similar level of reversion to the patients' original baselines in some markers of their cardiometabolic health – a category which includes conditions such as diabetes and heart attacks. Both Rubino and other experts around the world have seen similar patterns when administering GLP-1 drugs in their clinics. "There will be a small proportion of people, 10% maximum, that are able to maintain [all] the weight they've lost," says Alex Miras, a clinical professor of medicine at Ulster University.
    - orwin 2y ago
      2/3 of the weight back seems high to me, but the people I know also retired during their treatment, maybe some cofunding factors exist.
    - diffeomorphism 2y ago
      So even with rebound they lost more than 5% of their body weight long term. Seems good.

alamortsubite 2y ago

People are effectively on these medications permanently or they regain whatever weight they lost on them. So unfortunately the transition isn't so much to healthier diets, but to taking weight-loss drugs forever.

orwin 2y ago
Is this true? Is the rebound effect as high as you think? Because I know 2 people who took it for like 3 years, and while they took some weight back, they're not obese anymore.
- alamortsubite 2y ago
  Not according to Novo Nordisk. https://www.bbc.com/future/article/20240521-what-happens-when-you-stop-taking-ozempic https://www.bbc.com/future/article/20240521-what-happens-whe... The same trend was seen after the 2021 trial, known as Step 1. After 68 weeks of semaglutide injections, the average patient lost more than 15% of their body weight, but within 12 months of treatment ending, patients regained two thirds of their prior weight loss on average. This was associated with a similar level of reversion to the patients' original baselines in some markers of their cardiometabolic health – a category which includes conditions such as diabetes and heart attacks. Both Rubino and other experts around the world have seen similar patterns when administering GLP-1 drugs in their clinics. "There will be a small proportion of people, 10% maximum, that are able to maintain [all] the weight they've lost," says Alex Miras, a clinical professor of medicine at Ulster University.
  - orwin 2y ago
    2/3 of the weight back seems high to me, but the people I know also retired during their treatment, maybe some cofunding factors exist.
  - diffeomorphism 2y ago
    So even with rebound they lost more than 5% of their body weight long term. Seems good.