5 ms·

Inflammation also burns up NAD+ in the body as shown by skyrocketing CRP levels (C-Reactive Protein) It's one of the reasons why B3 supplements like NMN and NR

by ck2 2y ago

Inflammation also burns up NAD+ in the body as shown by skyrocketing CRP levels (C-Reactive Protein) It's one of the reasons why B3 supplements like NMN and NR (and niacin) are all the rage for "anti-aging" right now to restore NAD+ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146930/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146930/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908681/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908681/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138308/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138308/ https://www.researchgate.net/figure/hs-CRP-levels-in-different-age-groups-Each-bar-represents-the-median-and-95CI-as_fig1_327536451 https://www.researchgate.net/figure/hs-CRP-levels-in-differe...

qorrect 2y ago
Are you taking any NAD+ supplements? I am as of a week ago, just curious if anyone else is.
- bruce343434 2y ago
  How are you tracking the efficacy? Did you measure an actual deficiency in your blood? What effects are you hoping for? If you don't get the desired effects, what will you do? I always feel a bit of FOMO whenever supplements are being discussed, then again if I bought all the supplements every time I'd have a whole apothecary...
  - inglor_cz 2y ago
    N == 1, but after I started taking NR, my slow descent towards presbyopia (I am 45 now) stopped and reversed itself.
    - qorrect 2y ago
      What brand are you taking can I ask?
      - inglor_cz 2y ago
        Tru Niagen.
- the__alchemist 2y ago
  I'm taking NMN.
unsupp0rted 2y ago
Would a person with normal CRP (measured incidentally a couple times a year) want to take NAD+?
- ck2 2y ago
  There is virtually no benefit and only downsides to healthy people under 40 supplementing NAD+ via any pathway. The supplement people will still happily market/sell it to you though, old-school niacin is only 10 cents a day but fancy new NMN/NR is easily $1 a day, they are making a fortune.
  - voisin 2y ago
    Doesn’t niacin lead to prettt severe hot flashes / flushing of the face and extremities? I know someone who was told to take it for cholesterol (I think) and it sounded painful!
    - simpsond 2y ago
      Yes, too much niacin can make your entire body flush with a burning sensation.
    - ck2 2y ago
      Niacin mega-doses have been used for decades to reduce lipids, triglycerides, etc. and yes when you take 1 gram it will causes a painful flushing. However to simply raise NAD+ levels you can take as little as 100mg
  - unsupp0rted 2y ago
    I'm iffy on niacin, after reading too much HN. > Surprising link found between niacin and risk of heart attack and stroke > Breakdown products of niacin, aka Vitamin B3, may spur vascular inflammation. https://arstechnica.com/science/2024/02/surprising-link-found-between-niacin-and-risk-of-heart-attack-and-stroke/ https://arstechnica.com/science/2024/02/surprising-link-foun...

by ck2 2y ago

qorrect 2y ago

Are you taking any NAD+ supplements? I am as of a week ago, just curious if anyone else is.

bruce343434 2y ago
How are you tracking the efficacy? Did you measure an actual deficiency in your blood? What effects are you hoping for? If you don't get the desired effects, what will you do? I always feel a bit of FOMO whenever supplements are being discussed, then again if I bought all the supplements every time I'd have a whole apothecary...
- inglor_cz 2y ago
  N == 1, but after I started taking NR, my slow descent towards presbyopia (I am 45 now) stopped and reversed itself.
  - qorrect 2y ago
    What brand are you taking can I ask?
    - inglor_cz 2y ago
      Tru Niagen.
the__alchemist 2y ago
I'm taking NMN.

unsupp0rted 2y ago

Would a person with normal CRP (measured incidentally a couple times a year) want to take NAD+?

ck2 2y ago
There is virtually no benefit and only downsides to healthy people under 40 supplementing NAD+ via any pathway. The supplement people will still happily market/sell it to you though, old-school niacin is only 10 cents a day but fancy new NMN/NR is easily $1 a day, they are making a fortune.
- voisin 2y ago
  Doesn’t niacin lead to prettt severe hot flashes / flushing of the face and extremities? I know someone who was told to take it for cholesterol (I think) and it sounded painful!
  - simpsond 2y ago
    Yes, too much niacin can make your entire body flush with a burning sensation.
  - ck2 2y ago
    Niacin mega-doses have been used for decades to reduce lipids, triglycerides, etc. and yes when you take 1 gram it will causes a painful flushing. However to simply raise NAD+ levels you can take as little as 100mg
- unsupp0rted 2y ago
  I'm iffy on niacin, after reading too much HN. > Surprising link found between niacin and risk of heart attack and stroke > Breakdown products of niacin, aka Vitamin B3, may spur vascular inflammation. https://arstechnica.com/science/2024/02/surprising-link-found-between-niacin-and-risk-of-heart-attack-and-stroke/ https://arstechnica.com/science/2024/02/surprising-link-foun...