Only in science fiction, I think. See https://www.amazon.com/Souls-Great-Machine-Greatwinter-Trilogy/dp/0312872569 https://www.amazon.com/Souls-Great-Machine-G

Only in science fiction, I think. See https://www.amazon.com/Souls-Great-Machine-Greatwinter-Trilogy/dp/0312872569 https://www.amazon.com/Souls-Great-Machine-Greatwinter-Trilo... in which case natural neural-based computers are used to implement digital computation. I imagine the folks who built this: https://en.wikipedia.org/wiki/Turing_Tumble https://en.wikipedia.org/wiki/Turing_Tumble may have used computers to design/optimize the parts.