I assume that any large scale colonization of space will involve deeply modified germline humans: reduced oxygen requirements, greater tolerance to radiation, f

I assume that any large scale colonization of space will involve deeply modified germline humans: reduced oxygen requirements, greater tolerance to radiation, fewer rigid bones, tolerance to many forms of low gravity, loss of ability to live on the surface of a high G planet. And I guess an increased tolerance to boredom given how long it takes to get anywhere when minimizing energy expenditure.