AF2 and 3 both make accurate predictions of novel folds, and the larger community has confirmed this. AF3 stands as one of the greatest achievments in machine

AF2 and 3 both make accurate predictions of novel folds, and the larger community has confirmed this. AF3 stands as one of the greatest achievments in machine learning/structural biology we've yet seen. They do remove duplicates by sequence similarity (filtered PDB). Please assume the DM folks really do know what they are doing.