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The Promise of 5-MeO-DMT
- CuriouslyC 2y agoFrom personal experience, I can tell you 5-meo-dmt is mostly worse for most people than DMT. It's darker, more nausea inducing (normally the caapi in ayahuasca is the thing that makes you sick, not really the DMT), the body load is higher and it's just a more stressful experience all around than DMT.
- quechimba 2y agoLast time I drank ayahuasca with huambisa/chaliponga (contains 5-meo-dmt) I vomited every 5-10 minutes for about 4 hours. It was horrible, and I had to ask for help because I couldn't even get up and refill my water bottle. Chacruna is more gentle and smooth.
- turrini 2y agoDrink pomegranate juice and eat some ginger 20 minutes before. That stops any nausea with Ayahuasca for 6-8 hours, it evens "fix" the horrible taste to many.
- kinakomochidayo 2y agoI think it’d be counterproductive to stop the nausea, when nausea is an integral part of the Ayahuasca process of letting go, in addition to crying, yawning, sweating, etc. I just listen to my body and let it do its thing; sometimes I need to purge, sometimes I don’t need to purge.
- turrini 2y agoIt stops the nausea, but you still can purge (can't tell why). But it feels that you are just cleaning your body. And without nausea you can listen, IMHO, to your body, more carefully
- kinakomochidayo 2y agoI never imagined being able to vomit without the nausea, so that’s pretty interesting hah
- turrini 2y agoYMMV, but for several friends and me, the urge comes all at once and the purge happens. It's like an "immediate" nausea.
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- CuriouslyC 2y agoThe purge isn't necessary for healing, shamans use your physical purging as an anchor to help you emotionally purge, but that's just another technique.
- kinakomochidayo 2y agoWas the 5-MEO from the plants or toad? I heard that the toad one is much lighter than the plant one
- CuriouslyC 2y agoI've had both chaliponga and lab 5-meo. I find oral lab 5-meo unpleasant, but chaliponga does have some other impurities that amplify the problem. I think smoking 5-meo makes a lot of the side effects less noticeable compared with regular DMT, but it still has this more dark, muddy, wild feeling and a weight, whereas I find regular DMT to be clear and light by comparison.
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- heed 2y agoI'm not trying to tell anyone what to do.. but these toads (like the Sonoran desert toad) are increasingly becoming endangered due to poaching. It is possible to milk the venom without harming them, but a lot of poachers aren't careful or use the wrong techniques. I also understand people believe that there is a qualitative difference between the venom and synthetic, but it's the same compound at the end of the day.
- temp0826 2y agoThe experience is highly dependent on dosage (it's harder to fight the big dose) and on how willing you are to let go (of everything- all your storylines, loved ones, your life itself). The freakouts and struggles you see on youtube happen when one can't fully give in to it. IME, after the (very intense) come up, it is pure love and bliss. Going all the way feels like dissolving into god, and coming back you feel indescribably light and reborn. It's quite literally an ineffable experience at points, as if it turns off your mind (ego death/dissolution?) and you experience life temporarily from the heart with a completely non-dual view. (YMMV, I love the stuff but I also have a bit of experience in these more intense states; I work at a traditional ayahuasca healing center and usually drink 4 times a week). It's definitely not a recreational substance.
- karmakurtisaani 2y ago4 times per week? That's insane, how do you cope with that? Is it always equally pleasant?
- temp0826 2y agoIt's definitely not for everyone haha. You get a rhythm with it, take lots of naps etc. The medicine does give you some energy to do the work, and you generally feel good from the vine. We take a couple months off a year and don't usually drink during those breaks. It's hardest when we ourselves are also doing master plant diets (even more restrictive than the usual "ayahuasca diet", no salt/oil/etc). Always equally pleasant? No of course not. Some nights it's unbelievable and profound. The "hard" nights are still good as we're still learning to clean the things causing it. It's rarely mundane and (through the tradition we practice) there's always something to do, in ourselves or for our guests.
- CuriouslyC 2y agoI should qualify, I've been a practitioner for quite a while now, so I've crossed over many times. Above ego dissolution threshold, a lot of stuff feels pretty similar, but each molecule definitely has its own character. My personal preference is a mixture of caapi paste and a citrus juice extraction of p. cubensis and dried kratom leaf. The progression is quite fast and it can be incredibly intense but the body load and nausea are much reduced.
- jes5199 2y agoyikes, my DMT experiences were dark enough already, thank you
- fnord77 2y agoI know someone who tried DMT and it triggered severe long term anxiety in them. They went from a functional professional who had some issues to someone who couldn't leave the house. That was six years ago and last I checked on them in February their condition has been deteriorating. I don't believe any of these substances will ever be approved for legal medical use. They just seem to unpredictable and can cause as much harm as healing.
- stouset 2y agoAnd prescription medications don’t have rare but nasty side effects? If these things are unpredictable it’s likely because they simply haven’t been studied in a medical context. At the very least it’s reasonably clear that long-term and debilitating side effects are generally exceedingly rare. More people than you probably expect die from tylenol.
- thepasswordis 2y agoI can’t think of a single prescription medication which, when taken according to recommendations, causes permanent, irreversible, traumatic psychological damage after one dose.
- klyrs 2y agoSuicidality is a common side effect of many antidepressants.
- olleromam91 2y agoNot after one prescribed dosage though…that’s the point.
- wafflemaker 2y agoBut compared to regular Big Pharma meds, one dose of psychedelics is usually the whole treatment. Getting out of depression or other severe conditions is hard, whether using psychedelics or SSRI. Take care of yourself so you don't get there in the first place.
- 3rlk5 2y ago[dead]
- ProjectArcturis 2y agoWell, doing blinded studies will certainly be a challenge.
- coffeebeqn 2y agoI wonder how strong the placebo effect can be in this kind of a study.
- mordae 2y agoHahaha, maybe if they control with LSD which we've studied extensively since sixties... Not.
- virtualwhys 2y agoTo say that 5-MeO is a short duration psychedelic doesn't convey what's actually happening -- basically, you go from your normal waking state to likely the most profound experience of your life, and then, if you felt so inclined, back to work...all within 10-20 minutes. That's precisely what I didn't like about it, the rapid shift back to everyday consciousness. At least with other psychedelics you can spend an entire day in the woods, feeling the entire ebb and flow of the experience, and perhaps learn something in that process. With 5-MeO it's just instant God realm, and then, hmmm, what's for breakfast? Strange substance :) Finally, it's not for the feint of heart; until you try it you have no idea what you're getting into -- there is no preparation for the rocketship that is 5-MeO.
- temp0826 2y agoInsulfated 5-meo is the way to go. Slower come up (10-15 mins) and lasts quite a bit longer. Still very intense but not the rocket ship.
- Lisdexamfeta 2y agoIt was amazing for me. "Amazing" ofc does not mean easy or fun. But words only poorly convey what the sensations are like.
- neom 2y agohttps://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2016.00211/full https://www.frontiersin.org/journals/pharmacology/articles/1... You might enjoy reading about this then. DMTx got extra googling.
- nico 2y agoI’ve read of people taking it, experiencing a whole life (some up to 60+ years), and then coming back The experience is not exclusive to psychedelics either. It can happen through intense physical trauma, like a car accident. There’s a case of a guy who, while unconscious after a car crash, had the experience of being married and having kids, spending several years in that life. Then after waking up, he got depressed missing the family he had while unconscious Wild