4 ms·
>So the criticism towards AlphaFold 2 will likely still apply? For example, it’s more accurate for predicting structures similar to existing ones, and fails at
by COGlory 2y ago
>So the criticism towards AlphaFold 2 will likely still apply? For example, it’s more accurate for predicting structures similar to existing ones, and fails at novel patterns?
Yes, and there is simply no way to bridge that gap with this technique. We can make it better and better at pattern matching, but it is not going to predict novel folds.
- dekhn 2y agoalphafold has been shown to accurately predict some novel folds. The technique doesn't entirely depend on whole-domain homology.
- flobosg 2y ago> but it is not going to predict novel folds https://www.nature.com/articles/s42003-022-03357-1 https://www.nature.com/articles/s42003-022-03357-1