4 ms·
I can't find free access to the full paper, but here's the abstract (afraid I'm not knowledgeable enough to add to or explain any of it): "The accumulation of
by swores 3y ago
I can't find free access to the full paper, but here's the abstract (afraid I'm not knowledgeable enough to add to or explain any of it):
"The accumulation of metabolic waste is a leading cause of numerous neurological disorders, yet we still have only limited knowledge of how the brain performs self-cleansing. Here we demonstrate that neural networks synchronize individual action potentials to create large-amplitude, rhythmic and self-perpetuating ionic waves in the interstitial fluid of the brain. These waves are a plausible mechanism to explain the correlated potentiation of the glymphatic flow1,2 through the brain parenchyma. Chemogenetic flattening of these high-energy ionic waves largely impeded cerebrospinal fluid infiltration into and clearance of molecules from the brain parenchyma. Notably, synthesized waves generated through transcranial optogenetic stimulation substantially potentiated cerebrospinal fluid-to-interstitial fluid perfusion. Our study demonstrates that neurons serve as master organizers for brain clearance. This fundamental principle introduces a new theoretical framework for the functioning of macroscopic brain waves."
https://pubmed.ncbi.nlm.nih.gov/38418877/ https://pubmed.ncbi.nlm.nih.gov/38418877/
- salawat 3y ago>Chemogenetic flattening of these high-energy ionic waves largely impeded cerebrospinal fluid infiltration into and clearance of molecules from the brain parenchyma. Sounds like unsync'd brain waves, (being awake) impedes cerebrospinal fluid flow through the brain. When asleep, neurons sync their action potentials, acting like a ionized fluid pump, moving old dirty cerebrospinal fluid out, and allowing new, clean in. Interestingly, when they synthesize that type of ionization using other means, they saw the same increase in fluid movement. This is my best attempt at translating. Hopefully within 1-2 football fields. The author leaves choice of American or the rest of the world to the reader to decide.
- samstave 3y agoI wonder if this state could be ultrasonically induced to have a "sleep helmet" which can calm and align rhythmic waves? and induce an artificial flush or "power nap" -- Well, thats basically the trope of every Cybernetic design, with the connectors comming out the back of head/spine... Like a continual wash which keeps you in this suspended hyper-aware, but calm, rested and focused mental state. This is why cyborgs have such incredible reflexes.
- eschatology 3y agoI was thinking if we could directly tap and pump fresh cerebrospinal fluid and eliminate sleep
- brandensilva 3y agoIt seems neat in theory but I imagine the brain having to operate an additional 8 hours a day might actually accelerate mental decline faster as we age given you would be using it 1/3 more but it is an interesting concept.
- samstave 3y agoOr you just have a slow continuous flow, where the pumping is controlled by the heartbeat - meaning that whatever is pumping the BrainWash 9000(TM) is triggered by the impulses to the heart - however there is some monitoring system which also can slow or increase B9 as needed.
- 0xFEE1DEAD 3y agoHave you seen the video on hn a couple of weeks ago about the scientist using ultrasound to halt the progression of Alzheimer’s and to treat addiction? Most fascinating video I’ve seen in a long time. Edit: If you haven’t seen it yet, I highly recommend checking it out https://youtu.be/7BGtVJ3lBdE https://youtu.be/7BGtVJ3lBdE
- randcraw 3y agoIIRC, the goal of that effort is simply to violate the blood brain barrier, which may have therapeutic value only under very tightly managed circumstances since violating it likely will yield at least as many demerits as merits since the BBB is essential to keep the brain free of blood-borne toxins.
- samstave 3y agomanipulating the blood-brain-barrier is exactly what ALL ssris and medicines affecting the brain do.... DMT, LSD, MDMA etc all deal in these molocules. If we can create/prevent blood-brain-barrier-"Portals" as it were, via ultrasound - and do so like we do with the gamma knife but with sound waves, it would be more harmonious with our nature. (3/6/9 tesla rhythms and all that)
- Staple_Diet 3y agoAs someone in this field (research field not football field) I'd say that is an excellent layman explanation.
- parpfish 3y agoI wonder if these waves also help in “resetting” the distribution of ions among the CSF so neurons will continue to have the proper ion gradients for firing their action potentials?
- deleted 3y ago[deleted]
- SturgeonsLaw 3y ago> Here we demonstrate that neural networks synchronize individual action potentials to create large-amplitude, rhythmic and self-perpetuating ionic waves in the interstitial fluid of the brain This line is the money shot. An action potential is the variable electrical charge of a neuron, and they maintain that charge by containing a certain concentration of ions relative to the surrounding cerebrospinal fluid. This paper proposes that neurons synchonise their charge state, which forces ions to flow in or out of the neurons in bulk, the movement of these ions causing the cerebrospinal fluid to move around, clearing out the accumulated debris.
- niemandhier 3y agoI’d expect that it’s probably not the ion movement but the global electric field, maybe even mechanical effects in the axons. If you look at the Goldstein-Katz equations you see that the conductivities play an as important role as the concentrations. Most of the voltage change is driven by changes in conductivities and not concentration changes, the ion movements across the membrane should be negligible. Off course you have the free ions outside the cells than diffuse in a field gradient.
- walleeee 3y ago*Goldman-(Hodgkin-)Katz equation
- gentleman11 3y agoDo these wave of stimulation cause dreaming as a side effect?