Nature very specifically wants to be the venue where the most important and impactful discoveries are first reported, and they tolerate a very high false positi

Nature very specifically wants to be the venue where the most important and impactful discoveries are first reported, and they tolerate a very high false positive rate to achieve it. Quick, light peer review is part of that process. We always joked that if you read it in Nature, it was certain to be wrong, but realistically, it meant that the topic was likely an important one with a small number of competitive groups who could all evaluate each other's papers and will loudly complain about every inconsistency or irreproducible detail.