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It's a 16 to 20 week course of treatment and reduces risk of anaphylaxis for accidental exposure to food allergens. There is at least one other drug that is use
by DoreenMichele 3y ago
It's a 16 to 20 week course of treatment and reduces risk of anaphylaxis for accidental exposure to food allergens. There is at least one other drug that is used to treat peanut allergies, but this treats multiple food allergies.
Given that anaphylaxis can be deadly and staff at food places can be sometimes less than reliable about food allergy concerns, I can see this being appealing to someone with severe food allergies who wants a more normal life.
It would be nice if we figured out what causes allergies and fixed it but, I mean, we may never fully solve that. For some people, "take injections for a few weeks and be able to go out with friends without stressing this will involve another life-threatening health event and trip to the ER" will be of adequate value to endure the course of treatment.
- yosito 3y ago> staff at food places can be sometimes less than reliable about food allergy concerns As someone with Celiac disease, who often eats at restaurants, this is a bit of an understatement. Even in restaurants where things are marked allergen free on the menu, it is often the case that staff will make mistakes. More often than not, staff aren't even informed about the basics of food, things like eggs and dairy being two separate foods, or that they can't just scrape some sauce off of a bun if they put it there by mistake, etc. If I had a life threatening allergy, I would never set foot in a restaurant. It's terrifying.
- teen 3y agomaybe you're just allergic to glyphosate, not wheat. glyphosate is in pretty much everything now
- shwaj 3y agoThis might be true for people in general, but people who have been diagnosed with Celiac disease are definitely allergic to wheat.
- k_process 3y agohttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945755/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945755/ "Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance" Here, we propose that glyphosate is the most important causal factor in this [celiac disease and gluten intolerance] epidemic.
- refurb 3y agoDid you read the paper? My guess is no. Classic HN, references a paper as if the conclusions are fact and all references are equivalent. This is a paper where the authors did no experiments of their own, just put forth a hypotheses. The lead author is an “independent scientist”. Suffice to say I’d be very suspect of the conclusions drawn.
- bigbillheck 3y ago> The lead author is an “independent scientist”. The other one: https://en.wikipedia.org/wiki/Stephanie_Seneff https://en.wikipedia.org/wiki/Stephanie_Seneff
- refurb 3y agoOoph… “In 2011, she began publishing controversial papers in low-impact, open access journals on biology and medical topics; the articles have received "heated objections from experts in almost every field she's delved into,"”
- dahart 3y agoDon’t forget this awesome quote: “However, a recent paper (Samsel & Seneff, 2013), argued that glyphosate may be a key contributor to the obesity epidemic and the autism epidemic in the United States, as well as to several other diseases and conditions, such as Alzheimer's disease, Parkinson's disease, infertility, depression, and cancer.” It’s causing all the bad things? That would be amazing if true, unfortunately it sounds unlikely (chiropractic comes to mind) and the rest of the science world doesn’t believe these authors. If the graphs in the paper seem compelling, make sure to spend some time here: https://www.tylervigen.com/spurious-correlations https://www.tylervigen.com/spurious-correlations
- yosito 3y agoI have celiac disease. When I eat foods that contain gluten or a similar protein, avenin, it triggers an immune reaction which causes inflammation and damage in my intestines. It's not an allergy, it's not a wheat allergy, it's not a glyphosate allergy. You may keep your uninformed opinion.
- moneywoes 3y agohi fellow celiac any upcoming new celiac tech you find exciting?
- cosmodisk 3y agoOur daughter is allergic to a few things,nuts being one of them. When we ask for food information at restaurants, often staff have no clue. We had cases where they couldn't confirm for sure even after checking with the kitchen( we walked away).
- Broken_Hippo 3y agoI'm sorry, but why would you expect someone to know all of the food ingredients on the menu - even if they work there - if they don't personally prepare all of the foods? Heck, in the US, most of the places aren't even paying their staff a decent wage. Servers go by the menu as well. It isn't like there is a list most places. If the owners cared about your allergies, they'd make sure their staff could find out easily. Blame the folks that own the place, not the servers.
- watwut 3y agoIn many countries, the restaurants are expected to know allergens by law. Each food on the menu is supposed to have list of allergens available. Usually they are available right there in the menu, you do not even have to ask.
- cnity 3y agoI didn't read GP as blaming servers so much as demonstrating what is effectively systemic ignorance in the restaurant industry. The inability to 100% confirm ingredients is highlighted as not only being due to servers not knowing the exact contents of all meals (which is understandable), but also the fact that those who prepare and cook the meals as also being uncertain.
- windowsrookie 3y agoThe problem is a large portion of the food in restaurants is not prepared in the restaurant. If you order a burger meal, yes the meat is cooked on the grill at the restaurant, but the buns, and any sauce were likely made somewhere else. They might purchase the meat pre-seasoned from the food distributor. And the french fries likely even have a seasoning pre-applied to them before they are delivered to the restaurant.
- beacon294 3y agoCeliac is life threatening as far as I know.
- yosito 3y agoCeliac disease is life threatening like smoking is life threatening. Yes, it can kill you, if you regularly ignore the harm you are doing to your body and continue indulging. But someone with Celiac Disease isn't going to go into anaphylactic shock and die on the spot.
- neomantra 3y ago> staff at food places can be sometimes less than reliable about food allergy concerns In 2000, I was working at an NYC restaurant (Josie's on Third) -- it was a new non-dairy health-focused organic-everything restaurant. The waitstaff was trained in all the ingredients and many of the sources and were highly conscious of needs of our customers. We were tested on it a staff meal. One day, two friends sat to dine... we brought bread and our non-dairy spread. Customer asked "what is this?" I replied, "it is red-pepper tahini, an alternative to butter". I take their order, tend to other tables and arranging beverages, when I come back around 5 minutes later the table is empty. I ask my manager "what happened?" The lady had a severe sesame allergy and was rushed to the hospital -- *she did not know that tahini was sesame paste and I did not tell her*. I have no idea what happened to her and I think about this several times per year. For the last 15+ years, I have been a hands-on operator of complex computer systems operator. This experience has absolutely shaped how I communicate with teams, how I look at how failures may happen, how to expect the unexpected, etc. I now have a son with peanut allergies. It also influences how we dine. It is not easy and I'm glad there's out-of-band solutions like these drug therapies. We are not there yet, but might consider it.
- emeril 3y agoI remember Josies... nice place back then Definitely odd that a person with a severe sesame allergy didn't know about tahini - she can't even eat hummus That said, I suppose decades back such foods were less mainstream and/or she was new to the allergy
- pfannkuchen 3y ago> and I did not tell her I don’t think you should feel too bad about this. Having a severe sesame allergy and not knowing what tahini is and also not asking about sesame in dishes is quite reckless IMO. They were bound to accidentally eat something with tahini in it eventually.
- neomantra 3y agoThanks for that :) I don’t beat myself up — I did then! — but I do use it for reflection.
- cpuguy83 3y agoI am so sorry. I was a server... 20 years ago holy crap... I've been that server. They asked if something was safe for celiac. I had no idea, nobody else did either. Today, my partner is a severe celiac. Any traces of gluten takes them out for at least 2 weeks. Any hesitation from a restaurant from a restaurant and we are gone. I think that person ended up ordering. Of course literally nothing in that restaurant was safe for celiac if for nothing else than cross contamination. So sorry.
- mlrtime 3y agoTBH I don't think a server should be responsible to know all these things. They should be able to answer specific questions or find out from the Chef. Ultimately it's up to the customer to understand the risks of eating out.
- cpuguy83 3y agoCompletely disagree. For the restaurant in question it is a major national chain, so indeed it is harder for the server to have this knowledge on every dish, but at least a book of allergens... really the company should have this available in a friendly manner online. But even then, the server should absolutely know (and therefore be trained on) major allergens in the kitchen because its not just the food, its how its prepared. 20 years ago I didn't know, I didn't know that I ought to know. I didn't know that I could have caused that person significant harm. I was a teenager. But my managers absolutely should have known and not put me in that position where I didn't know something so fundamental to food service. We were trained on other things.
- mrgoldenbrown 3y agoThe staff should be able to answer questions about what ingredients are used in the kitchen and in specific dishes. but they shouldn't be responsible for answering the question as you posed it : "is this safe for someone with celiac" ? Safety is up to you to decide, as only the customer knows how sensitive they are and what the reaction will be.
- gnicholas 3y ago> It's a 16 to 20 week course of treatment The study refers to checking patients after this many weeks, but my understanding is that you're supposed to keep taking it forever. From NPR: > The medication is not intended for use during an allergic reaction. Instead, it is designed to be taken repeatedly every few weeks to help reduce the risk of reactions over time. 1: https://www.npr.org/2024/02/18/1232304606/fda-approval-food-allergies-xolair https://www.npr.org/2024/02/18/1232304606/fda-approval-food-...
- DoreenMichele 3y ago9 Duration of Therapy The appropriate duration of therapy for IgE-mediated food allergy has not been evaluated. Periodically reassess the need for continued therapy. https://www.gene.com/download/pdf/xolair_prescribing.pdf https://www.gene.com/download/pdf/xolair_prescribing.pdf
- kelnos 3y agoSo that's still not terrible, really. I've been getting allergy immunotherapy for the past 3.5 years (not for food allergies, for stuff like cat, dog, grass, dust mites, etc.), and I have to go for the shots once a month. It's honestly not that big a deal. I only have another 1.5 years until my treatment is over, but if I had to do it for the rest of my life, it wouldn't be the worst thing, given the benefits. This is of course assuming there aren't any bad reactions to this medicine... didn't read enough of the article or beyond to get that info.
- thatguy27 3y agoHi, Would you mind telling me what immunotherapy you get, specifically for cats? I'm currently on Grazax for grasses etc. I would love to be able to get a cat, but I am quite allergic and get flu-like symptoms after a while. (Also, my blood tests don't show that I'm allergic to cats, so that complicates things).
- amluto 3y agoIn the US, most clinics don’t make a point of showing the patient what the product is. They screen the patient (usually a skin test), prescribe either a single antigen formulation, a combination of antigens in different vials, or they mix up a custom vial for the patient, and they keep it in a fridge in the clinic. The antigens come from whatever provider the clinic buys them from.
- modeless 3y agoThe study lasted 20 weeks, but I believe you have to continue the treatment indefinitely if you want the effects to continue. It's not a permanent fix, and a once or twice monthly injection for the rest of my life is not something I'd like to sign up for.
- looping8 3y agoWe can hope it's not for the rest of one's life but only until a better solution is found. For people with deadly allergies, a few years of injections might not be too big of a price, I think.
- bennyg 3y agoYeah this is one of those perspective things. I’m on a once-a-month regimen of eyeball injections to stave off macular degeneration. I’d trade it in a heartbeat for allergy-reducing injection. But even my case feels “routine” now.
- modeless 3y agoI am not optimistic. The pace of progress in the field is very slow. Barring an AGI-induced revolution in medicine (not out of the question) I think the chances of curing common allergies in my lifetime are not super high.
- MrYellowP 3y agoWhy would any of the pharma companies out there want to invent a permanent cure, when there's far more money to be made with a cure that is not permanent? Makes no sense. A one time customer isn't lucrative.
- Broken_Hippo 3y agoFirst things first, pharma companies are OK with cures. Cures bring money as well, and some cures bring them patient trust. Pharma companies aren't the only factor here either. Insurance companies, patients, and governments are definitely invested in cures. Preventative measures are OK with these groups as well - vaccines are one of these. Not all research is by big pharma either. You are assuming other things bring magic profit when they don't do that as efficiently as you think. Curing one disease doesn't cure them all, and there would still be profit to be made off of your other sicknesses. Probably especially those tied to lifestyle. You are also assuming that we know how to cure the diseases we have treatments for. This is the real reason we don't have more cures - we know a good deal about the body, but there is a good deal we simply don't know. It isn't that I think these folks are innocent - I have anger towards those exploiting sick folks to make obscene profits and the industry is greedy - but I don't buy your argument at all. It doesn't allow for the nuance that actual life has and only works if you don't look below the surface.
- ImHereToVote 3y agoThere are countries with significantly less allergies amongst children. The difference is so stark as to be visible at the country border level. This is well studied. For political reasons, I'm gonna let you search what those countries are for yourself.
- meindnoch 3y agoElaborate, please!
- mtlmtlmtlmtl 3y agoLook up the hygiene hypothesis, I believe that's what they're referring to.
- wouldbecouldbe 3y agoIt would probably be a good idea to make it a recommendation to start giving allergy prone foods such as peanuts in small dosis to baby's so there is a higher chance for developing a tolerance.
- theNJR 3y agoThis is now the recommendation. Companies even make allergen packets to add to your baby’s breast milk / formula / early foods for gradual and systemic exposure.
- HorizonXP 3y agoI’m in that camp. My kids and I don’t have issues, but my wife does. We’ve had to de-train in Germany once and go to a hospital due to a reaction while on vacation. Last week in NYC, we bought food and were ensured that it didn’t have nuts. But we forgot to ask about sesame seeds/oil. No hospital this time, but she was unwell (vomiting) for the rest of the trip. We are pretty vigilant. If her anaphylactic reactions were more severe (I.e. airway constricting) we would be much more strict. But this approval seems perfect for us, since it won’t change our routines, but means we’re not punished for accidents.