6 ms·

> consumption of >6 cups/day was associated with 53% higher odds of dementia compared to consumption of 1–2 cups/day (fully adjusted OR 1.53, 95% CI 1.28, 1.83)

> consumption of >6 cups/day was associated with 53% higher odds of dementia compared to consumption of 1–2 cups/day (fully adjusted OR 1.53, 95% CI 1.28, 1.83) 6+ cups! That’s a cranial marinade.

doubled112 3y ago
My mom, both of my sisters and I drink it by the pot. Each of us, every day. 6 cups? That doesn't sound like enough coffee to me.
- op00to 3y ago
  I can’t even drink a single cup of coffee without shaking and getting intense anxiety.
  - doubled112 3y ago
    Perhaps someday we'll discover a coffee tolerance gene.
    - xcv123 3y ago
      The gene is called CYP1A2 with two variants. One variant is a rapid caffeine metabolizer. The other is a slow caffeine metabolizer. https://www.geneticlifehacks.com/liver-detox-genes-cyp1a2/ https://www.geneticlifehacks.com/liver-detox-genes-cyp1a2/ I have the rapid variant but could not sleep well on 6 cups.
      - JonChesterfield 3y ago
        That is interesting information. I note that the same enzyme breaks down melatonin. If a variant that is particularly efficient at caffeine is also particularly efficient at breaking down melatonin, the symptom would be difficulty getting to sleep independent of amount of caffeine, which is totally fixed by taking melatonin tablets.
      - b800h 3y ago
        Slow metaboliser here. If I drink a coffee at 11am my heart rate rises and doesn't return to normal until the following morning. There are other genes for it too, like one that affects the degree to which coffee causes anxiety. And plenty of others that we haven't found, presumably.
        op00to 3y ago
        I love love love love coffee. It took me years to realize that my high blood pressure was controlled almost immediately by cutting out a high-test canned “Draft Latte” drink. I can drink a single 8oz cup every few days. Decaf is fine.
- PH95VuimJjqBqy 3y ago
  6 cups are scrub numbers, if you haven't done that by 10am you're behind the curve :P
- FirmwareBurner 3y ago
  >My mom, both of my sisters and I drink it by the pot. Each of us, every day. Can I ask how's your sleep?
  - 2OEH8eoCRo0 3y ago
    Sleep was fine. I used to drink it by the pot but I cut back mainly because I'd have to piss too much.
    - doubled112 3y ago
      Yes, this is my main motivator when I cut back. If I have to drive a long drive, as an example, I’ll skip coffee that day. I’d rather save stops.
  - doubled112 3y ago
    I seem to sleep as well as I always have. I go to bed when I am tired. Usually 11pm-1am. I fall asleep in a few minutes. Then I wake up about 7am, feeling OK. Closer to 6 hours is more normal for me. I’ve been like that since I was a teenager and I didn't drink coffee then.
op00to 3y ago
That’s like a little more than 2 venti Starbucks.
- FirmwareBurner 3y ago
  > more than 2 venti Americans will do anything to not use the metric system :)
  - zdragnar 3y ago
    Venti is the Starbucks name for their largest size cup, which holds 20 ounces. Most people don't really care about the exact, specific volume of fluid, they just go by whatever the cup size happens to be called. At least it is more descriptive than the grande or short cups, or the small / medium / large at other places (even if you have to know that venti is 20 in Italian to make the connection).
    - Uinchuling 3y ago
      I doubt I'm the only obnoxious country dude who rolls into Starbucks and orders a "large". You can ignore their pretentious names, they're very accommodating.
      - datavirtue 3y ago
        Too insecure to use the size names. That's how it plays...fyi
        yanellena 3y ago
        It's probably more that you don't want a corporation to dictate how you describe (brand) the sizes of a drink where we have near universal language for that purpose already.
        the_third_wave 3y ago
        Too much experience with cattle and thus not longing to resemble them. One of 'm says 'moo' and soon the rest follows. Now just imagine a ${city_equivalent_of_field} full of city folk where one of 'm says 'venti' and you understand what I mean.
Kirby64 3y ago
The scientific definition of a 'cup' of coffee is important. Usually this is defined as 4 ounces of brewed coffee, which means a normal mug of coffee (which can fit something like 10 oz) would be 2.5 cups! So, for most people's definition of a 'cup' of coffee, they really only mean 2.5 'mugs' of coffee.
- OJFord 3y ago
  And surely the amount of water is inconsequential, why can't we just use grams of actual coffee? Then we don't have to worry about how many espressos are in a 10oz mug. (Nevermind what that person's considering a standard dose for the espresso!)
  - Kirby64 3y ago
    Measuring extraction ratio on coffee is difficult and wildly varies based on preparation method. The standard “cup” assumes 4oz of coffee, using 5oz of brew water (so, 1oz stays in the coffee grounds as waste). I believe there’s also a standard amount of coffee grounds used as well, though.
  - jna_sh 3y ago
    Different brew methods extract differing amounts from the coffee, so the amount of water is indeed consequential. Same grams of coffee in to a pour-over vs espresso would result in different amounts of extracted coffee material consumed.
    - OJFord 3y ago
      True. I'm inclined to think it would be closer than 'do whatever you want in order to end up with an Xoz drink' though!
      - Kirby64 3y ago
        Prep method matters so much though. For comparison, a standard double shot of espresso is typically 18g of coffee. This would yield approximately 110mg of caffeine. By comparison, the same 18g brewed using a pour over method should yield an 8oz cup of coffee with … likely around 170mg of caffeine. Check out this James Hoffmann video specifically on this topic: https://youtube.com/watch?v=etnMr8oUSDo https://youtube.com/watch?v=etnMr8oUSDo
lp4vn 3y ago
I used to drink one liter of coffee a day, and I would prepare it in a measured cup by the way so it's not an exaggeration.
Jcampuzano2 3y ago
I used to drink along the lines of this much coffee or more. I was travelling very often and often working 12+ hour days for weeks on end. I look back on those days and just thinking about it reminds me of my constantly tweaking eyes, lack of sleep, constant hyperactivity, anxiousness, stress etc. I stopped cold turkey for a while but nowadays have settled on more like 1-2 a day and never after a specific time of day (for me I hard stop at 3pm). Having any more than this or after this time kills my sleep immediately.
- SOLAR_FIELDS 3y ago
  Decaf is something I’ve really started to enjoy over the last couple of years. I’ll have one mug of actual coffee in the morning to start my day and then anywhere from 1-3 mugs of decaf. Back in the day it was not an equivalent option due to the chemical extraction process making it taste inferior. Now with water processed beans being offered with my local roaster it’s just about the same level of taste
euroderf 3y ago
Great album title, Cranial Marinade.
TyrianPurple 3y ago
Coffee & Tea are both stimulants. So I wouldn't be wrong by coming to the same conclusion about tea drinkers. Guess my cranium has been marinated real good.

doubled112 3y ago

My mom, both of my sisters and I drink it by the pot. Each of us, every day. 6 cups? That doesn't sound like enough coffee to me.

op00to 3y ago
I can’t even drink a single cup of coffee without shaking and getting intense anxiety.
- doubled112 3y ago
  Perhaps someday we'll discover a coffee tolerance gene.
  - xcv123 3y ago
    The gene is called CYP1A2 with two variants. One variant is a rapid caffeine metabolizer. The other is a slow caffeine metabolizer. https://www.geneticlifehacks.com/liver-detox-genes-cyp1a2/ https://www.geneticlifehacks.com/liver-detox-genes-cyp1a2/ I have the rapid variant but could not sleep well on 6 cups.
    - JonChesterfield 3y ago
      That is interesting information. I note that the same enzyme breaks down melatonin. If a variant that is particularly efficient at caffeine is also particularly efficient at breaking down melatonin, the symptom would be difficulty getting to sleep independent of amount of caffeine, which is totally fixed by taking melatonin tablets.
    - b800h 3y ago
      Slow metaboliser here. If I drink a coffee at 11am my heart rate rises and doesn't return to normal until the following morning. There are other genes for it too, like one that affects the degree to which coffee causes anxiety. And plenty of others that we haven't found, presumably.
      - op00to 3y ago
        I love love love love coffee. It took me years to realize that my high blood pressure was controlled almost immediately by cutting out a high-test canned “Draft Latte” drink. I can drink a single 8oz cup every few days. Decaf is fine.
PH95VuimJjqBqy 3y ago
6 cups are scrub numbers, if you haven't done that by 10am you're behind the curve :P
FirmwareBurner 3y ago
>My mom, both of my sisters and I drink it by the pot. Each of us, every day. Can I ask how's your sleep?
- 2OEH8eoCRo0 3y ago
  Sleep was fine. I used to drink it by the pot but I cut back mainly because I'd have to piss too much.
  - doubled112 3y ago
    Yes, this is my main motivator when I cut back. If I have to drive a long drive, as an example, I’ll skip coffee that day. I’d rather save stops.
- doubled112 3y ago
  I seem to sleep as well as I always have. I go to bed when I am tired. Usually 11pm-1am. I fall asleep in a few minutes. Then I wake up about 7am, feeling OK. Closer to 6 hours is more normal for me. I’ve been like that since I was a teenager and I didn't drink coffee then.

op00to 3y ago

That’s like a little more than 2 venti Starbucks.

FirmwareBurner 3y ago
> more than 2 venti Americans will do anything to not use the metric system :)
- zdragnar 3y ago
  Venti is the Starbucks name for their largest size cup, which holds 20 ounces. Most people don't really care about the exact, specific volume of fluid, they just go by whatever the cup size happens to be called. At least it is more descriptive than the grande or short cups, or the small / medium / large at other places (even if you have to know that venti is 20 in Italian to make the connection).
  - Uinchuling 3y ago
    I doubt I'm the only obnoxious country dude who rolls into Starbucks and orders a "large". You can ignore their pretentious names, they're very accommodating.
    - datavirtue 3y ago
      Too insecure to use the size names. That's how it plays...fyi
      - yanellena 3y ago
        It's probably more that you don't want a corporation to dictate how you describe (brand) the sizes of a drink where we have near universal language for that purpose already.
      - the_third_wave 3y ago
        Too much experience with cattle and thus not longing to resemble them. One of 'm says 'moo' and soon the rest follows. Now just imagine a ${city_equivalent_of_field} full of city folk where one of 'm says 'venti' and you understand what I mean.

Kirby64 3y ago

The scientific definition of a 'cup' of coffee is important. Usually this is defined as 4 ounces of brewed coffee, which means a normal mug of coffee (which can fit something like 10 oz) would be 2.5 cups! So, for most people's definition of a 'cup' of coffee, they really only mean 2.5 'mugs' of coffee.

OJFord 3y ago
And surely the amount of water is inconsequential, why can't we just use grams of actual coffee? Then we don't have to worry about how many espressos are in a 10oz mug. (Nevermind what that person's considering a standard dose for the espresso!)
- Kirby64 3y ago
  Measuring extraction ratio on coffee is difficult and wildly varies based on preparation method. The standard “cup” assumes 4oz of coffee, using 5oz of brew water (so, 1oz stays in the coffee grounds as waste). I believe there’s also a standard amount of coffee grounds used as well, though.
- jna_sh 3y ago
  Different brew methods extract differing amounts from the coffee, so the amount of water is indeed consequential. Same grams of coffee in to a pour-over vs espresso would result in different amounts of extracted coffee material consumed.
  - OJFord 3y ago
    True. I'm inclined to think it would be closer than 'do whatever you want in order to end up with an Xoz drink' though!
    - Kirby64 3y ago
      Prep method matters so much though. For comparison, a standard double shot of espresso is typically 18g of coffee. This would yield approximately 110mg of caffeine. By comparison, the same 18g brewed using a pour over method should yield an 8oz cup of coffee with … likely around 170mg of caffeine. Check out this James Hoffmann video specifically on this topic: https://youtube.com/watch?v=etnMr8oUSDo https://youtube.com/watch?v=etnMr8oUSDo

lp4vn 3y ago

I used to drink one liter of coffee a day, and I would prepare it in a measured cup by the way so it's not an exaggeration.

Jcampuzano2 3y ago

I used to drink along the lines of this much coffee or more. I was travelling very often and often working 12+ hour days for weeks on end. I look back on those days and just thinking about it reminds me of my constantly tweaking eyes, lack of sleep, constant hyperactivity, anxiousness, stress etc. I stopped cold turkey for a while but nowadays have settled on more like 1-2 a day and never after a specific time of day (for me I hard stop at 3pm). Having any more than this or after this time kills my sleep immediately.

SOLAR_FIELDS 3y ago
Decaf is something I’ve really started to enjoy over the last couple of years. I’ll have one mug of actual coffee in the morning to start my day and then anywhere from 1-3 mugs of decaf. Back in the day it was not an equivalent option due to the chemical extraction process making it taste inferior. Now with water processed beans being offered with my local roaster it’s just about the same level of taste

euroderf 3y ago

Great album title, Cranial Marinade.

TyrianPurple 3y ago

Coffee & Tea are both stimulants. So I wouldn't be wrong by coming to the same conclusion about tea drinkers. Guess my cranium has been marinated real good.