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Ohalo (the company Dave Friedberg is now CEO of) recently got approval for a potato edited by CRISPR: > Ohalo had two RSRs under consideration this year for it

Ohalo (the company Dave Friedberg is now CEO of) recently got approval for a potato edited by CRISPR: > Ohalo had two RSRs under consideration this year for its potato, one which focuses on higher concentrations of beta carotene – enhancing the overall health and nutrition value of the potato – and another which results in reduced glucose and fructose content in the potato, which, according to Ohalo, will reduce the adverse side effects that lead to significant spoilage during cold storage of potatoes. https://thespoon.tech/gene-edited-food-startup-ohalo-emerges-from-stealth-as-agtech-pioneer-dave-friedberg-takes-the-helm/ https://thespoon.tech/gene-edited-food-startup-ohalo-emerges...

jabbany 3y ago
Hmmm. That second one reminds me of the Flavr Savr (https://en.m.wikipedia.org/wiki/Flavr_Savr https://en.m.wikipedia.org/wiki/Flavr_Savr). More shelf life in exchange for likely worse taste...
- huytersd 3y ago
  Worse taste but probably healthier in this case.
  - SoftTalker 3y ago
    Yeah potatoes will fill your stomach and better than starving but they aren't really healthy food. Eat them in moderation, and prefer sweet potatoes/yams.
    - pastor_bob 3y ago
      >prefer sweet potatoes/yams. Sweet potatoes, as you might expect, have more sugar in them. As do garnet yams. The issue with potatoes isn't really their (low) sugar content.
    - spondylosaurus 3y ago
      On the contrary, potatoes are full of good stuff: https://www.mayoclinichealthsystem.org/hometown-health/speaking-of-health/its-ok-to-say-yes-to-potatoes https://www.mayoclinichealthsystem.org/hometown-health/speak... Just make sure to go easy on the toppings!
      - 2devnull 3y ago
        That says, “ true that potatoes are high in starch or carbohydrates, the nutrients that cause spikes in blood sugar. But pairing them with foods high in protein, fiber and unsaturated fats can slow digestion and lead to a steadier release of glucose into the bloodstream.” Which suggests you should add toppings or else potatoes are not very healthy if eaten on their own. (I think they’re fairly high up on the glycemic index).
freedomben 3y ago
thanks that's neat, although I wish it wasn't with a Solanaceae member. Do you know if they are working on other types of produce or are they just working on potatoes?
- biomcgary 3y ago
  Are you concerned about off-target edits activating toxin producing pathways?
  - Modified3019 3y ago
    Maybe they are referring to the small percentage of people are sensitive to the whole family (potatoes, tomatoes, peppers, tobacco, etc) and find any exposure produces inflammation/digestion issues.
    - freedomben 3y ago
      yes it's both actually! Potatoes are wildly toxic to humans when they have any green on them, and that can actually happen in the refrigerator if left to long and then consumed. They have the capacity to really F us up. Editing those strikes me as like threading a needle between hair triggers. You don't want to miss your target. But also yes exactly, the whole family can cause inflammation and difficulties in people sensitive to them (which tragically because I love spicy food, includes me D-:). So that means that any cool stuff they do I won't be able to try.
      - imtringued 3y ago
        Don't worry, once they figured it out they are going to put this stuff in every food and you won't be able to eat anything at the supermarket anymore.
pastor_bob 3y ago
>and another which results in reduced glucose and fructose content in the potato, That's pretty amazing. Imagine if we can change apples to produce Aspartame instead of sugars!
- iwontberude 3y ago
  I don’t see how a plant is supposed to metabolize the aspartame for energy?
  - maxerickson 3y ago
    It would only be a successful reproductive strategy if some external actor decided to propagate the plants that were putting something not useful to the seeds into the fruit.
- hedora 3y ago
  Unless you are diabetic, aspartame is much worse for you than sugar. It causes metabolic issues, such as reduced metabolism (leading to more weight gain than a subjectively equivalent amount of sugar), migraines in some people, interacts with drugs, is bad for your digestive tract, and probably has other side effects. Even if you are diabetic, you can already eat apples. They have a low glycemic index.
  - liamwire 3y ago
    Extraordinary claims require extraordinary evidence. Can you back any of this up, or provide a reason I should believe what you’re saying? Because it directly contradicts decades of research on what is perhaps the most scrutinised and studied dietary supplement in the world. Aspartame is safe, and very well tolerated. You’re spreading misinformation.
    - willmadden 3y ago
      You are the one spreading misinformation. Aspartame is horrible for you. Here, have a read. I have more if you would like them. https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003950 https://journals.plos.org/plosmedicine/article?id=10.1371/jo... https://www.sciencedaily.com/releases/2022/03/220324143800.htm https://www.sciencedaily.com/releases/2022/03/220324143800.h... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1392232/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1392232/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1964906/pdf/ehp0115-001293.pdf http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1964906/pdf/ehp0... http://www.mpwhi.com/soffritti_2010_20896_fta.pdf http://www.mpwhi.com/soffritti_2010_20896_fta.pdf https://ehjournal.biomedcentral.com/articles/10.1186/s12940-021-00725-y https://ehjournal.biomedcentral.com/articles/10.1186/s12940-... https://annalsofglobalhealth.org/articles/10.5334/aogh.4163 https://annalsofglobalhealth.org/articles/10.5334/aogh.4163 http://ajcn.nutrition.org/content/96/6/1419.long http://ajcn.nutrition.org/content/96/6/1419.long https://www.ncbi.nlm.nih.gov/pubmed/24436139 https://www.ncbi.nlm.nih.gov/pubmed/24436139 https://www.pnas.org/doi/10.1073/pnas.2213120119 https://www.pnas.org/doi/10.1073/pnas.2213120119 https://news.fsu.edu/news/university-news/2022/12/08/fsu-research-links-common-sweetener-with-anxiety/ https://news.fsu.edu/news/university-news/2022/12/08/fsu-res... https://www.nature.com/articles/s41598-023-41213-2 https://www.nature.com/articles/s41598-023-41213-2 https://www.ncbi.nlm.nih.gov/pubmed/8939194 https://www.ncbi.nlm.nih.gov/pubmed/8939194 https://www.youtube.com/watch?v=yCoBuTr0Or0 https://www.youtube.com/watch?v=yCoBuTr0Or0 http://www.cmaj.ca/content/189/28/E929 http://www.cmaj.ca/content/189/28/E929 https://www.statnews.com/2017/07/17/artificial-sweeteners-weight-loss/ https://www.statnews.com/2017/07/17/artificial-sweeteners-we... https://blogs.wsj.com/experts/2017/09/14/why-one-cardiologist-has-drunk-his-last-diet-soda/ https://blogs.wsj.com/experts/2017/09/14/why-one-cardiologis... https://www.philly.com/philly/health/this-cardiologist-wants-his-family-to-cut-back-on-diet-soda-should-yours-too-20170912.html https://www.philly.com/philly/health/this-cardiologist-wants... https://www.ncbi.nlm.nih.gov/pubmed/27129676 https://www.ncbi.nlm.nih.gov/pubmed/27129676 http://stroke.ahajournals.org/content/early/2017/04/20/STROKEAHA.116.016027 http://stroke.ahajournals.org/content/early/2017/04/20/STROK... https://www.bumc.bu.edu/busm/2017/04/20/daily-consumption-of-sodas-fruit-juices-and-artificially-sweetened-sodas-affect-brain/ https://www.bumc.bu.edu/busm/2017/04/20/daily-consumption-of... https://www.washingtonpost.com/news/morning-mix/wp/2017/04/21/study-links-diet-soda-to-higher-risk-of-stroke-dementia/?utm_term=.2bfedb009058 https://www.washingtonpost.com/news/morning-mix/wp/2017/04/2... https://www.ncbi.nlm.nih.gov/pubmed/24787915 https://www.ncbi.nlm.nih.gov/pubmed/24787915 https://www.ncbi.nlm.nih.gov/pubmed/24787917 https://www.ncbi.nlm.nih.gov/pubmed/24787917 https://www.ncbi.nlm.nih.gov/pubmed/1579221 https://www.ncbi.nlm.nih.gov/pubmed/1579221 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474447/pdf/envhper00434-0053.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474447/pdf/env... https://www.ncbi.nlm.nih.gov/pubmed/28198207 https://www.ncbi.nlm.nih.gov/pubmed/28198207 https://www.ncbi.nlm.nih.gov/pubmed/28049023 https://www.ncbi.nlm.nih.gov/pubmed/28049023 https://www.ncbi.nlm.nih.gov/pubmed/17684524 https://www.ncbi.nlm.nih.gov/pubmed/17684524 http://www.sciencedirect.com/science/article/pii/S1043661805001404 http://www.sciencedirect.com/science/article/pii/S1043661805... https://diabetesjournals.org/care/article/doi/10.2337/dc23-0206/153434/Artificial-Sweeteners-and-Risk-of-Type-2-Diabetes https://diabetesjournals.org/care/article/doi/10.2337/dc23-0... https://www.ncbi.nlm.nih.gov/pubmed/27997218 https://www.ncbi.nlm.nih.gov/pubmed/27997218 http://www.massgeneral.org/News/pressrelease.aspx?id=2016 http://www.massgeneral.org/News/pressrelease.aspx?id=2016 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772345/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772345/
rcarr 3y ago
Pretty cool, I wonder if it changes the chemical composition of the soil in any way compared to a regular potato.
seydor 3y ago
monster-potato?
graphe 3y ago
I would have bred them for more potato protein. It's a very close meat protein substitute by essential amino acids. Might be why it tastes so good. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245118/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245118/ >Of the ten plant-based proteins included in the current analysis, potato protein is the only protein source containing the WHO/FAO/UNU requirements for all essential amino acids. Thus, when consuming potato protein as the only dietary protein source at the recommended adult protein intake level of 0.66 g/kg/day, sufficient amounts of all essential amino acids should be consumed. It remains to be investigated whether the ingestion of a single meal-like amount of potato protein has the capacity to stimulate muscle protein synthesis. Anyone know about vegan protein profiles and best ones now?
- gen220 3y ago
  I supplement protein, filtered for vegan because my body doesn't like whey, and Pea protein is pretty solid. It's a "complete" protein and doesn't require any complicated processing steps, just drying, pulverizing, and a centrifuge step to spin out the fiber.
  - smt88 3y ago
    Are you sure that's all they do? Peas aren't even close to 100% protein, so you'd be eating a very high-carb powder if that were the case.
    - gen220 3y ago
      Yep, here's an article [1] describing the process. Here's some youtube video I found showing the various steps [2]. They don't have to use any chemical solutions more exotic than water and air. I bungled the explanation with "centrifuge", it's more complicated than that, but the fiber content is removed in that step. [1]: https://gogood.co.nz/blogs/news/how-is-pea-protein-manufactured https://gogood.co.nz/blogs/news/how-is-pea-protein-manufactu... [2]: https://www.youtube.com/watch?v=wbX_w0ZIunM https://www.youtube.com/watch?v=wbX_w0ZIunM
    - byproxy 3y ago

jabbany 3y ago

Hmmm. That second one reminds me of the Flavr Savr (https://en.m.wikipedia.org/wiki/Flavr_Savr https://en.m.wikipedia.org/wiki/Flavr_Savr). More shelf life in exchange for likely worse taste...

huytersd 3y ago
Worse taste but probably healthier in this case.
- SoftTalker 3y ago
  Yeah potatoes will fill your stomach and better than starving but they aren't really healthy food. Eat them in moderation, and prefer sweet potatoes/yams.
  - pastor_bob 3y ago
    >prefer sweet potatoes/yams. Sweet potatoes, as you might expect, have more sugar in them. As do garnet yams. The issue with potatoes isn't really their (low) sugar content.
  - spondylosaurus 3y ago
    On the contrary, potatoes are full of good stuff: https://www.mayoclinichealthsystem.org/hometown-health/speaking-of-health/its-ok-to-say-yes-to-potatoes https://www.mayoclinichealthsystem.org/hometown-health/speak... Just make sure to go easy on the toppings!
    - 2devnull 3y ago
      That says, “ true that potatoes are high in starch or carbohydrates, the nutrients that cause spikes in blood sugar. But pairing them with foods high in protein, fiber and unsaturated fats can slow digestion and lead to a steadier release of glucose into the bloodstream.” Which suggests you should add toppings or else potatoes are not very healthy if eaten on their own. (I think they’re fairly high up on the glycemic index).

freedomben 3y ago

thanks that's neat, although I wish it wasn't with a Solanaceae member. Do you know if they are working on other types of produce or are they just working on potatoes?

biomcgary 3y ago
Are you concerned about off-target edits activating toxin producing pathways?
- Modified3019 3y ago
  Maybe they are referring to the small percentage of people are sensitive to the whole family (potatoes, tomatoes, peppers, tobacco, etc) and find any exposure produces inflammation/digestion issues.
  - freedomben 3y ago
    yes it's both actually! Potatoes are wildly toxic to humans when they have any green on them, and that can actually happen in the refrigerator if left to long and then consumed. They have the capacity to really F us up. Editing those strikes me as like threading a needle between hair triggers. You don't want to miss your target. But also yes exactly, the whole family can cause inflammation and difficulties in people sensitive to them (which tragically because I love spicy food, includes me D-:). So that means that any cool stuff they do I won't be able to try.
    - imtringued 3y ago
      Don't worry, once they figured it out they are going to put this stuff in every food and you won't be able to eat anything at the supermarket anymore.

pastor_bob 3y ago

>and another which results in reduced glucose and fructose content in the potato, That's pretty amazing. Imagine if we can change apples to produce Aspartame instead of sugars!

iwontberude 3y ago
I don’t see how a plant is supposed to metabolize the aspartame for energy?
- maxerickson 3y ago
  It would only be a successful reproductive strategy if some external actor decided to propagate the plants that were putting something not useful to the seeds into the fruit.
hedora 3y ago
Unless you are diabetic, aspartame is much worse for you than sugar. It causes metabolic issues, such as reduced metabolism (leading to more weight gain than a subjectively equivalent amount of sugar), migraines in some people, interacts with drugs, is bad for your digestive tract, and probably has other side effects. Even if you are diabetic, you can already eat apples. They have a low glycemic index.
- liamwire 3y ago
  Extraordinary claims require extraordinary evidence. Can you back any of this up, or provide a reason I should believe what you’re saying? Because it directly contradicts decades of research on what is perhaps the most scrutinised and studied dietary supplement in the world. Aspartame is safe, and very well tolerated. You’re spreading misinformation.
  - willmadden 3y ago
    You are the one spreading misinformation. Aspartame is horrible for you. Here, have a read. I have more if you would like them. https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003950 https://journals.plos.org/plosmedicine/article?id=10.1371/jo... https://www.sciencedaily.com/releases/2022/03/220324143800.htm https://www.sciencedaily.com/releases/2022/03/220324143800.h... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1392232/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1392232/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1964906/pdf/ehp0115-001293.pdf http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1964906/pdf/ehp0... http://www.mpwhi.com/soffritti_2010_20896_fta.pdf http://www.mpwhi.com/soffritti_2010_20896_fta.pdf https://ehjournal.biomedcentral.com/articles/10.1186/s12940-021-00725-y https://ehjournal.biomedcentral.com/articles/10.1186/s12940-... https://annalsofglobalhealth.org/articles/10.5334/aogh.4163 https://annalsofglobalhealth.org/articles/10.5334/aogh.4163 http://ajcn.nutrition.org/content/96/6/1419.long http://ajcn.nutrition.org/content/96/6/1419.long https://www.ncbi.nlm.nih.gov/pubmed/24436139 https://www.ncbi.nlm.nih.gov/pubmed/24436139 https://www.pnas.org/doi/10.1073/pnas.2213120119 https://www.pnas.org/doi/10.1073/pnas.2213120119 https://news.fsu.edu/news/university-news/2022/12/08/fsu-research-links-common-sweetener-with-anxiety/ https://news.fsu.edu/news/university-news/2022/12/08/fsu-res... https://www.nature.com/articles/s41598-023-41213-2 https://www.nature.com/articles/s41598-023-41213-2 https://www.ncbi.nlm.nih.gov/pubmed/8939194 https://www.ncbi.nlm.nih.gov/pubmed/8939194 https://www.youtube.com/watch?v=yCoBuTr0Or0 https://www.youtube.com/watch?v=yCoBuTr0Or0 http://www.cmaj.ca/content/189/28/E929 http://www.cmaj.ca/content/189/28/E929 https://www.statnews.com/2017/07/17/artificial-sweeteners-weight-loss/ https://www.statnews.com/2017/07/17/artificial-sweeteners-we... https://blogs.wsj.com/experts/2017/09/14/why-one-cardiologist-has-drunk-his-last-diet-soda/ https://blogs.wsj.com/experts/2017/09/14/why-one-cardiologis... https://www.philly.com/philly/health/this-cardiologist-wants-his-family-to-cut-back-on-diet-soda-should-yours-too-20170912.html https://www.philly.com/philly/health/this-cardiologist-wants... https://www.ncbi.nlm.nih.gov/pubmed/27129676 https://www.ncbi.nlm.nih.gov/pubmed/27129676 http://stroke.ahajournals.org/content/early/2017/04/20/STROKEAHA.116.016027 http://stroke.ahajournals.org/content/early/2017/04/20/STROK... https://www.bumc.bu.edu/busm/2017/04/20/daily-consumption-of-sodas-fruit-juices-and-artificially-sweetened-sodas-affect-brain/ https://www.bumc.bu.edu/busm/2017/04/20/daily-consumption-of... https://www.washingtonpost.com/news/morning-mix/wp/2017/04/21/study-links-diet-soda-to-higher-risk-of-stroke-dementia/?utm_term=.2bfedb009058 https://www.washingtonpost.com/news/morning-mix/wp/2017/04/2... https://www.ncbi.nlm.nih.gov/pubmed/24787915 https://www.ncbi.nlm.nih.gov/pubmed/24787915 https://www.ncbi.nlm.nih.gov/pubmed/24787917 https://www.ncbi.nlm.nih.gov/pubmed/24787917 https://www.ncbi.nlm.nih.gov/pubmed/1579221 https://www.ncbi.nlm.nih.gov/pubmed/1579221 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474447/pdf/envhper00434-0053.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474447/pdf/env... https://www.ncbi.nlm.nih.gov/pubmed/28198207 https://www.ncbi.nlm.nih.gov/pubmed/28198207 https://www.ncbi.nlm.nih.gov/pubmed/28049023 https://www.ncbi.nlm.nih.gov/pubmed/28049023 https://www.ncbi.nlm.nih.gov/pubmed/17684524 https://www.ncbi.nlm.nih.gov/pubmed/17684524 http://www.sciencedirect.com/science/article/pii/S1043661805001404 http://www.sciencedirect.com/science/article/pii/S1043661805... https://diabetesjournals.org/care/article/doi/10.2337/dc23-0206/153434/Artificial-Sweeteners-and-Risk-of-Type-2-Diabetes https://diabetesjournals.org/care/article/doi/10.2337/dc23-0... https://www.ncbi.nlm.nih.gov/pubmed/27997218 https://www.ncbi.nlm.nih.gov/pubmed/27997218 http://www.massgeneral.org/News/pressrelease.aspx?id=2016 http://www.massgeneral.org/News/pressrelease.aspx?id=2016 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772345/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772345/

rcarr 3y ago

Pretty cool, I wonder if it changes the chemical composition of the soil in any way compared to a regular potato.

seydor 3y ago

monster-potato?

graphe 3y ago

I would have bred them for more potato protein. It's a very close meat protein substitute by essential amino acids. Might be why it tastes so good. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245118/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245118/ >Of the ten plant-based proteins included in the current analysis, potato protein is the only protein source containing the WHO/FAO/UNU requirements for all essential amino acids. Thus, when consuming potato protein as the only dietary protein source at the recommended adult protein intake level of 0.66 g/kg/day, sufficient amounts of all essential amino acids should be consumed. It remains to be investigated whether the ingestion of a single meal-like amount of potato protein has the capacity to stimulate muscle protein synthesis. Anyone know about vegan protein profiles and best ones now?

gen220 3y ago
I supplement protein, filtered for vegan because my body doesn't like whey, and Pea protein is pretty solid. It's a "complete" protein and doesn't require any complicated processing steps, just drying, pulverizing, and a centrifuge step to spin out the fiber.
- smt88 3y ago
  Are you sure that's all they do? Peas aren't even close to 100% protein, so you'd be eating a very high-carb powder if that were the case.
  - gen220 3y ago
    Yep, here's an article [1] describing the process. Here's some youtube video I found showing the various steps [2]. They don't have to use any chemical solutions more exotic than water and air. I bungled the explanation with "centrifuge", it's more complicated than that, but the fiber content is removed in that step. [1]: https://gogood.co.nz/blogs/news/how-is-pea-protein-manufactured https://gogood.co.nz/blogs/news/how-is-pea-protein-manufactu... [2]: https://www.youtube.com/watch?v=wbX_w0ZIunM https://www.youtube.com/watch?v=wbX_w0ZIunM
  - byproxy 3y ago