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This has to be balanced against this news: "Daily low dose aspirin increases brain bleeding risk by 38% in older adults." See: https://www.medicalnewstoday.com/

This has to be balanced against this news: "Daily low dose aspirin increases brain bleeding risk by 38% in older adults." See: https://www.medicalnewstoday.com/articles/low-dose-aspirin-raises-brain-bleeding-risk https://www.medicalnewstoday.com/articles/low-dose-aspirin-r...

deleted 3y ago
[deleted]
DoesntMatter22 3y ago
It should be noted that you can get a lot of aspirin from vegetables, which also contain aspirin. This video talks about a similar study and the plant foods that have highest doses of aspirin, all without stomach bleeding. https://www.youtube.com/watch?v=BcmoILbgmwc https://www.youtube.com/watch?v=BcmoILbgmwc
hammock 3y ago
Which is worse?
- onionisafruit 3y ago
  I know which one I would rather die from. It isn’t cancer.
  - MattRix 3y ago
    Well the worseness has to be counteracted by how likely it is. A 38% increase in something quite rare (brain bleeds) is nowhere near as impactful as a 20% reduction in cancer, which is much more common.
    - smitty1110 3y ago
      From 0.8% of people averaging 70 years of age to 1.1%. I’ll take those odds, cancer is hell.
- noodlenotes 3y ago
  Note that the patients in the meta-analysis already had cancer.
nradov 3y ago
Yes, we need to see a long-term study of all cause mortality before recommending this intervention for primary prevention.
- akdor1154 3y ago
  There are probably many as per article.. here is one: https://aspree.org/aus/for-clinicians/ https://aspree.org/aus/for-clinicians/ Focused on elderly, i think mostly started with subjects at 70? So depends on how 'long term' you mean. :)
darkerside 3y ago
100% reduction in cancer deaths in those with self inflicted gunshot wounds to the head
alejohausner 3y ago
Brain bleeding is very rare. That 38% number is a *relative risk ratio*. I'm always wary of studies that use such ratios to make an effect seem large. The following excerpts from the article you cited state: For the study, the researchers analyzed data from 19,114 adults with an average age of 74 years old. Altogether, 1.1% of those taking aspirin (108 individuals) experienced intracranial bleeding, while the same was true for 0.8% of those taking a placebo (79 individuals).
- dvfjsdhgfv 3y ago
  It always amazes me how you can take numbers and twist them they way they fit you and be technically correct. I bet many (if not most) people will only remember the headline.
  - nathancahill 3y ago
    Check out the famous book "How to Lie with Statistics"
    - pcdoodle 3y ago
      This is the book that was next to Bill Gates during his television interviews a few years back when we considered him a health professional.
deleted 3y ago
[deleted]
tagrun 3y ago
It says in older adults. This is a meta-study, touching on that "contrast" already: there is a subsection in the paper dedicated to this, where they claim that "The major factor in cerebral bleeding however is hypertension, and in an RCT of aspirin based on more than 18,000 hypertensive patients—all of whom were receiving ‘optimal’ antihypertensive treatment—there were no additional cerebral bleeds in patients randomised to aspirin" (Refs 46 and 47). which seems to be in contradiction with the article corresponding to the news you linked to: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2807630 https://jamanetwork.com/journals/jamanetworkopen/fullarticle... and strangely doesn't cite or comment on Refs 46 and 47 from the paper of the main thread, possibly because they don't seem to be focusing on older adults. There is also a subsection on gastrointestinal bleeding. Intracranial bleeding isn't necessary something that cause permanent damage, or lethal by the way.
enasterosophes 3y ago
Aspirin is also associated with gout. I'm not sure if the dosage required to worsen gout is lower than the dose discussed in the paper. I merely caution that anyone thinking about increasing their aspirin usage to prevent cancer should consult a GP first, since it's complicated, and anyone who has had gout probably doesn't want to increase their rate of flare ups.

deleted 3y ago

[deleted]

DoesntMatter22 3y ago

It should be noted that you can get a lot of aspirin from vegetables, which also contain aspirin. This video talks about a similar study and the plant foods that have highest doses of aspirin, all without stomach bleeding. https://www.youtube.com/watch?v=BcmoILbgmwc https://www.youtube.com/watch?v=BcmoILbgmwc

hammock 3y ago

Which is worse?

onionisafruit 3y ago
I know which one I would rather die from. It isn’t cancer.
- MattRix 3y ago
  Well the worseness has to be counteracted by how likely it is. A 38% increase in something quite rare (brain bleeds) is nowhere near as impactful as a 20% reduction in cancer, which is much more common.
  - smitty1110 3y ago
    From 0.8% of people averaging 70 years of age to 1.1%. I’ll take those odds, cancer is hell.
noodlenotes 3y ago
Note that the patients in the meta-analysis already had cancer.

nradov 3y ago

Yes, we need to see a long-term study of all cause mortality before recommending this intervention for primary prevention.

akdor1154 3y ago
There are probably many as per article.. here is one: https://aspree.org/aus/for-clinicians/ https://aspree.org/aus/for-clinicians/ Focused on elderly, i think mostly started with subjects at 70? So depends on how 'long term' you mean. :)

darkerside 3y ago

100% reduction in cancer deaths in those with self inflicted gunshot wounds to the head

alejohausner 3y ago

Brain bleeding is very rare. That 38% number is a *relative risk ratio*. I'm always wary of studies that use such ratios to make an effect seem large. The following excerpts from the article you cited state: For the study, the researchers analyzed data from 19,114 adults with an average age of 74 years old. Altogether, 1.1% of those taking aspirin (108 individuals) experienced intracranial bleeding, while the same was true for 0.8% of those taking a placebo (79 individuals).

dvfjsdhgfv 3y ago
It always amazes me how you can take numbers and twist them they way they fit you and be technically correct. I bet many (if not most) people will only remember the headline.
- nathancahill 3y ago
  Check out the famous book "How to Lie with Statistics"
  - pcdoodle 3y ago
    This is the book that was next to Bill Gates during his television interviews a few years back when we considered him a health professional.

deleted 3y ago

[deleted]

tagrun 3y ago

It says in older adults. This is a meta-study, touching on that "contrast" already: there is a subsection in the paper dedicated to this, where they claim that "The major factor in cerebral bleeding however is hypertension, and in an RCT of aspirin based on more than 18,000 hypertensive patients—all of whom were receiving ‘optimal’ antihypertensive treatment—there were no additional cerebral bleeds in patients randomised to aspirin" (Refs 46 and 47). which seems to be in contradiction with the article corresponding to the news you linked to: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2807630 https://jamanetwork.com/journals/jamanetworkopen/fullarticle... and strangely doesn't cite or comment on Refs 46 and 47 from the paper of the main thread, possibly because they don't seem to be focusing on older adults. There is also a subsection on gastrointestinal bleeding. Intracranial bleeding isn't necessary something that cause permanent damage, or lethal by the way.

enasterosophes 3y ago

Aspirin is also associated with gout. I'm not sure if the dosage required to worsen gout is lower than the dose discussed in the paper. I merely caution that anyone thinking about increasing their aspirin usage to prevent cancer should consult a GP first, since it's complicated, and anyone who has had gout probably doesn't want to increase their rate of flare ups.