4 ms·

How does this square with the fact that isoleucine is important for muscle mass development?

XorNot 3y ago
It doesn't. And honestly the result should be treated skeptically until someone replicates it. Mice studies like this have a ton caveats: the animal lives 3 years versus the human 100 years. Research like this is better for understanding biochemical pathways then whole organism affects, especially since "aging" isn't a well defined phenomenon (it's a grab bag of other things we want to prevent).
globular-toast 3y ago
That muscle mass development has nothing to do with living healthier or longer?
- throwawaaarrgh 3y ago
  Well it's correlated, in that the resistance training associated with developing muscle mass also increases bone density and other factors that lead to living longer. Curious what would happen if you did resistance training while simultaneously stunting the development of muscle. Would you still get the same health benefits?
terribleperson 3y ago
Wild-assed guess: the benefits of increased muscle mass and bone density matter much more to humans than they do to mice. We are large and heavy, while mice are small and light.
WillPostForFood 3y ago
Apparently it wasn't an issue? The article says mice on the low-isoleucine diet did better on muscle strength.
11235813213455 3y ago
we don't need much muscle
- nradov 3y ago
  We really do. Especially as we age, maintaining a large amount of lean muscle is essential for metabolic health and preventing disabling injuries. https://gabriellereece.com/muscle-as-the-cornerstone-of-longevity-optimizing-strength-for-disease-prevention-with-dr-gabrielle-lyon/ https://gabriellereece.com/muscle-as-the-cornerstone-of-long... https://peterattiamd.com/outlive/ https://peterattiamd.com/outlive/
  - 11235813213455 3y ago
    "maintaining a large amount of lean muscle is essential" I doubt about this. Maintaining exercise sure, maintaining low fat tissue sure, mintaining essential muscles comes as a result of daily activity: walking, using less devices and more manual processes, taking stairs rather than elevators, this makes more sense than going to gym, because diverse muscles work, in a more natural and physiological way Look at centarians profiles, they're light, active, and not eating a lot (very little meat, mostly plant based)

It doesn't. And honestly the result should be treated skeptically until someone replicates it. Mice studies like this have a ton caveats: the animal lives 3 years versus the human 100 years. Research like this is better for understanding biochemical pathways then whole organism affects, especially since "aging" isn't a well defined phenomenon (it's a grab bag of other things we want to prevent).

globular-toast 3y ago

That muscle mass development has nothing to do with living healthier or longer?

throwawaaarrgh 3y ago
Well it's correlated, in that the resistance training associated with developing muscle mass also increases bone density and other factors that lead to living longer. Curious what would happen if you did resistance training while simultaneously stunting the development of muscle. Would you still get the same health benefits?

terribleperson 3y ago

Wild-assed guess: the benefits of increased muscle mass and bone density matter much more to humans than they do to mice. We are large and heavy, while mice are small and light.

WillPostForFood 3y ago

Apparently it wasn't an issue? The article says mice on the low-isoleucine diet did better on muscle strength.

11235813213455 3y ago

we don't need much muscle

nradov 3y ago
We really do. Especially as we age, maintaining a large amount of lean muscle is essential for metabolic health and preventing disabling injuries. https://gabriellereece.com/muscle-as-the-cornerstone-of-longevity-optimizing-strength-for-disease-prevention-with-dr-gabrielle-lyon/ https://gabriellereece.com/muscle-as-the-cornerstone-of-long... https://peterattiamd.com/outlive/ https://peterattiamd.com/outlive/
- 11235813213455 3y ago
  "maintaining a large amount of lean muscle is essential" I doubt about this. Maintaining exercise sure, maintaining low fat tissue sure, mintaining essential muscles comes as a result of daily activity: walking, using less devices and more manual processes, taking stairs rather than elevators, this makes more sense than going to gym, because diverse muscles work, in a more natural and physiological way Look at centarians profiles, they're light, active, and not eating a lot (very little meat, mostly plant based)