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I imagine this wouldn't be a huge issue with women since they don't produce eggs after birth, but men continue to produce gametes for life. Is there a way to pr
by foxyv 3y ago
I imagine this wouldn't be a huge issue with women since they don't produce eggs after birth, but men continue to produce gametes for life. Is there a way to prevent the introduction of the CRISPR edits to spermatocytes? Or do you just have to bank sperm and sterilize as a condition for the treatment?
- ch4s3 3y agoThey’re targeting specialized cells that make blood cells outside of the body. Once they’re reimplemented they don’t move around.
- foxyv 3y agoOkay, so they modify outside of the body and then transplant. So that's why it's sickle cell first, because they can do self-transplantation with bone marrow.
- dekhn 3y agoSpeaking generally, I think you could perform something like this on sperm stem cells. Sperm turn over (the full population dies and is replaced) fairly quickly, but the stem cells last a long time. It seems more likely they would just, uh, collect a sample of a single sperm cell and treat that, then use it with a treated egg using IVF.