5 ms·

Solves some of the initial problems with muscle tremors and control, but does nothing for the dementia that sets in later.

m463 3y ago
Is the dementia caused by the disease, or a correlated effect due to the loss of mobility and the ability to exercise, or swallow regular food, or similar? I've read that exercise, hard exercise, can mitigate or recover some of the effects of parkinsons.
- deleted 3y ago
  [deleted]
- maxerickson 3y ago
  Nuplazid, an antipsychotic marketed for Parkinson's, targets the imbalance created by the massive loss of dopermergenic cells. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007714/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007714/ It certainly had a significant impact on a Parkinson's patient I knew (from regular expressions of and involvement with delusional hallucinations to relatively normal, organized behavior). Of course the loss of cells might be self reinforcing.
- Veserv 3y ago
  The dementia is probably caused by the underlying mechanism. The motor symptoms of Parkinson’s are caused by the loss of dopamine producing neurons in the motor cortex. The loss of those neurons for any reason would cause Parkinson style motor symptoms. The cause of the loss of dopamine producing neurons in standard Parkinson’s is not understood, but appears to be related to a thing called Lewy bodies which are deposits of a protein called alpha-synuclein. The presence of Lewy bodies outside of the motor cortex is correlated with a disease called Lewy body dementia rather than Parkinson’s. Most likely, there is a underlying process that causes neuron loss that slowly spreads. This process frequently starts in the motor cortex resulting in Parkinson’s, but sometimes starts elsewhere causing Lewy body dementia. Dementia in a person with Parkinson’s likely occurs when the process starts spreading beyond the motor cortex which effectively causes Lewy body dementia now that it is no longer isolated to the motor cortex.
  - caycep 3y ago
    substantia nigra is nowhere near the cortex
    - Veserv 3y ago
      Doing some research on the terminology, I guess motor system is the term I was looking for. I am not a biologist so I am not familiar with the terminology.
  - wombatpm 3y ago
    My father passed from Lewy Body dementia. His brother died of Parkinson's. The diseases appear different in the order of symptoms, but are similar in the end.
melling 3y ago
10 more good years. Any thoughts on making a bigger effort to cure dementia? “The average time from onset of movement problems to the development of dementia is about 10 years.” https://memory.ucsf.edu/dementia/parkinsons/parkinson-disease-dementia#:~:text=Most%20people%20with%20PD%20start,dementia%20is%20about%2010%20years https://memory.ucsf.edu/dementia/parkinsons/parkinson-diseas....
thorncorona 3y ago
Exercise and diet are both effective at reducing the onset of PD. Being able to exercise on your own is HUGE
- nullserver 3y ago
  Had massive health problems dozens of doctors. Ended up being a combination of things, but changing diet to an autoimmune protocol diet was the number 2 thing that made a difference.
  - adaml_623 3y ago
    And the #1 thing was???
    - blensor 3y ago
      ... stopped worrying about off by one errors
    - nullserver 3y ago
      Blood thinners. Turned out I was genetically prone to clotting, which went bonkers after gas exposure. No amount Healthy lifestyle was going to help, needed something to stop clotting
      - adaml_623 3y ago
        Thank you for replying to me. I'm aware that it was a personal question. Super glad to hear that you found useful treatment.
- hirvi74 3y ago
  Oddly enough, so is tobacco/nicotine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019319/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019319/
vGPU 3y ago
There’s a fairly strong correlation between severity of Parkinson’s and vitamin D levels. It’s a nasty self-feeding decline as people tend to move less and spend less time outside as the disease progresses, which may potentially make the progression worse.

m463 3y ago

Is the dementia caused by the disease, or a correlated effect due to the loss of mobility and the ability to exercise, or swallow regular food, or similar? I've read that exercise, hard exercise, can mitigate or recover some of the effects of parkinsons.

deleted 3y ago
[deleted]
maxerickson 3y ago
Nuplazid, an antipsychotic marketed for Parkinson's, targets the imbalance created by the massive loss of dopermergenic cells. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007714/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007714/ It certainly had a significant impact on a Parkinson's patient I knew (from regular expressions of and involvement with delusional hallucinations to relatively normal, organized behavior). Of course the loss of cells might be self reinforcing.
Veserv 3y ago
The dementia is probably caused by the underlying mechanism. The motor symptoms of Parkinson’s are caused by the loss of dopamine producing neurons in the motor cortex. The loss of those neurons for any reason would cause Parkinson style motor symptoms. The cause of the loss of dopamine producing neurons in standard Parkinson’s is not understood, but appears to be related to a thing called Lewy bodies which are deposits of a protein called alpha-synuclein. The presence of Lewy bodies outside of the motor cortex is correlated with a disease called Lewy body dementia rather than Parkinson’s. Most likely, there is a underlying process that causes neuron loss that slowly spreads. This process frequently starts in the motor cortex resulting in Parkinson’s, but sometimes starts elsewhere causing Lewy body dementia. Dementia in a person with Parkinson’s likely occurs when the process starts spreading beyond the motor cortex which effectively causes Lewy body dementia now that it is no longer isolated to the motor cortex.
- caycep 3y ago
  substantia nigra is nowhere near the cortex
  - Veserv 3y ago
    Doing some research on the terminology, I guess motor system is the term I was looking for. I am not a biologist so I am not familiar with the terminology.
- wombatpm 3y ago
  My father passed from Lewy Body dementia. His brother died of Parkinson's. The diseases appear different in the order of symptoms, but are similar in the end.

melling 3y ago

10 more good years. Any thoughts on making a bigger effort to cure dementia? “The average time from onset of movement problems to the development of dementia is about 10 years.” https://memory.ucsf.edu/dementia/parkinsons/parkinson-disease-dementia#:~:text=Most%20people%20with%20PD%20start,dementia%20is%20about%2010%20years https://memory.ucsf.edu/dementia/parkinsons/parkinson-diseas....

thorncorona 3y ago

Exercise and diet are both effective at reducing the onset of PD. Being able to exercise on your own is HUGE

nullserver 3y ago
Had massive health problems dozens of doctors. Ended up being a combination of things, but changing diet to an autoimmune protocol diet was the number 2 thing that made a difference.
- adaml_623 3y ago
  And the #1 thing was???
  - blensor 3y ago
    ... stopped worrying about off by one errors
  - nullserver 3y ago
    Blood thinners. Turned out I was genetically prone to clotting, which went bonkers after gas exposure. No amount Healthy lifestyle was going to help, needed something to stop clotting
    - adaml_623 3y ago
      Thank you for replying to me. I'm aware that it was a personal question. Super glad to hear that you found useful treatment.
hirvi74 3y ago
Oddly enough, so is tobacco/nicotine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019319/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019319/

vGPU 3y ago

There’s a fairly strong correlation between severity of Parkinson’s and vitamin D levels. It’s a nasty self-feeding decline as people tend to move less and spend less time outside as the disease progresses, which may potentially make the progression worse.