6 ms·
Anti-ageing molecule boosts fertility in ageing mice
- extraduder_ire 3y agoThe molecule is Spermidine[0] apparently. Article: https://www.nature.com/articles/s43587-023-00498-8 https://www.nature.com/articles/s43587-023-00498-8 [0]: https://en.wikipedia.org/wiki/Spermidine https://en.wikipedia.org/wiki/Spermidine
- caesil 3y agoSpermidine boosts fertility? A little on the nose.
- chaps 3y agoNo you're supposed to swallow. The pill
- gpt5 3y agoBefore you order your Spermidine supplements: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143675/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143675/
- fbdab103 3y ago>(3) Results: Compared with a placebo, spermidine supplementation significantly increased spermine levels in the plasma, but it did not affect spermidine or putrescine levels. No effect on salivary polyamine concentrations was observed. Which might be fine if the metabolite is actually the responsible molecule.
- jychang 3y agoOrder? Considering the source of Spermidine, might be easier to get it for free from your local glory hole
- TedDoesntTalk 3y agoWheat germ is another source of spermadine and you can buy it at most supermarkets. Sprinkle over cereal
- scns 3y agoIt contains Phytic Acid. Might be the reason humans started removing it from wheat. It gets broken down in sour dough too. https://en.wikipedia.org/wiki/Phytic_acid?wprov=sfla1 https://en.wikipedia.org/wiki/Phytic_acid?wprov=sfla1 [edit] remove doubled word
- goda90 3y agoDoes the spermadine also get broken down in sour dough, or is whole wheat sour dough a potential good source?
- TedDoesntTalk 3y agoWhat’s wrong with phytic acid? I read the link you included. The only negative seems to be it might not be digestible, unless I missed something else?
- ben_w 3y agoGiven the concentration, you'd have to drink half a litre of human seminal plasma to match one 15mg supplement pill. I have no idea what the concentration of seminal plasma is in semen, but even if the latter was pure plasma that's still 135 sessions to equal one pill.
- AlexanderNull 3y agoThe 15mg/d they used in that study is just the standard dietary intake (top end, europeans). Looked a number of other studies that also used just regular intake levels as "supplementation". Weird how they all stay small when the no observable adverse effects level is much higher.
- BeFlatXIII 3y agoHelpful reminder that mice lie, monkeys exaggerate, and ferrets are not people (surprisingly enough).
- huytersd 3y agoI’m being serious here but can you consume your own… and see benefits? Does it make it through the digestive system?
- tetris11 3y agoThe cult of techbro science demands that you do so immediately without reading any prior research into the topic.
- wilg 3y agoRegretting reading these comments suddenly
- huytersd 3y agoWell I tried to keep it as implication as possible. There’s no way to make the question not sound crude unfortunately.
- ben_w 3y agoEven if it did, you'll get at least as much from eating about 60g of wheat germ as an unprotected sex worker would get if they had new clients every 3.5 minutes for 8 hours.
- badcppdev 3y agoThe study talks about how, "declining egg quality in older mice can be reversed with a dietary supplement". Sooo... unless you have a very specific genetic condition you are not going to be able to self dose and replicate the study.
- deleted 3y ago[deleted]
- pyrophane 3y agoHaven't heard of this before but it seems to be readily available online in supplement form.
- ganeshkrishnan 3y agoyou dont need to go for the supplements. just buy wheat germ from local grocery and have it in appropriate quantities
- pengaru 3y agoAged cheddar cheese also looks to be a good source, more fun to consume than wheat germ... https://en.wikipedia.org/wiki/Spermidine#Sources https://en.wikipedia.org/wiki/Spermidine#Sources
- harry8 3y agoFor whatever that might be worth...[1] [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143675/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143675/
- ganeshkrishnan 3y agoThe molecule is Spermidine. If you are interested in at-home trial to increase intake of spermidine, you can buy some wheat germ and either toast it and let it soak in water overnight. Its also good for autophagy and there has been no known side effects. Its just a plant product anyway! https://pubmed.ncbi.nlm.nih.gov/29315079/ https://pubmed.ncbi.nlm.nih.gov/29315079/
- temp10172023 3y ago[flagged]
- pixelpoet 3y ago> It's just a plant product anyway! So is heroin/opium...
- emanuele232 3y agoand Death Cap is just a mushroom!
- scubadude 3y agoArguably not a plant :-)
- DFHippie 3y agoFrom the article: > Getting the dose right is important, as the study also showed that excessive amounts of spermidine led to poorer quality oocytes in mice.
- alwillis 3y agoI first learned about Spermidine on David Sinclair's Lifespan podcast last year [1]; it's one of the supplements he takes daily [2]. [1]: https://www.lifespanpodcast.com/nmn-nr-resveratrol-metformin-and-other-molecules-for-longevity/ https://www.lifespanpodcast.com/nmn-nr-resveratrol-metformin... [2]: https://fastlifehacks.com/david-sinclair-supplements/ https://fastlifehacks.com/david-sinclair-supplements/
- Podgajski 3y agoIMHO, Sinclair is making a mistake by taking spermidine directly since it will probably deplete riboflavin (B2) because the excess spermidine will be metabolized my Spermine oxidase which uses B2 as a cofactor https://www.uniprot.org/uniprotkb/Q9NWM0/entry https://www.uniprot.org/uniprotkb/Q9NWM0/entry IMO, a better way is to trigger your own body to make spermidine by getting enough Arginine and taking Manganese, B6, and keeping your methylation cycle flowing. The pathway is as follows: Arginine -> (Arginase, uses manganese as a cofactor) -> Ornithine -> (Ornithine decarboxylase, uses B6 as a cofactor) -> putrescine -> (Spermidine synthase which needs SAMe and Pyruvate) -> Spermidine https://www.mdpi.com/metabolites/metabolites-12-00344/article_deploy/html/images/metabolites-12-00344-g001.png https://www.mdpi.com/metabolites/metabolites-12-00344/articl...
- Namari 3y agoShouldn't the patient take more B2 in that case?
- Podgajski 3y agoIn my opinion, yes. But I still feel the better route to increasing spermidine is finding out if you are deficiency in arginine, manganese, B6 or one of the several cofactors for the methylation cycle.
- Namari 3y agoThough, will having more Arginine, Manganese and B6 automatically trigger your own body to make spermidine? Isn't there maybe a limit when the body stops producing spermidine?
- m3kw9 3y agoSo it anti-ages my..nads only?
- swayvil 3y agoRick and Morty. Remember that videogame, Roy? Roy: A Life Well Lived is a Virtual Reality Life Simulator In the game, scientists are working to extend life. This translates to hacking the videogame's code. Success. The player of the game is locked in permanent catatonic fugue. Stays in game forever. Immortality achieved.
- badcppdev 3y agoAnother visitor! Stay a while; stay forever!
- chadcmulligan 3y agoThe lifetime of a universe isn't that long for an immortal though
- balnaphone 3y agoDr Brad Stanfield suggests this doesn't work in humans. https://www.youtube.com/watch?v=dVvqGAjg_J8 https://www.youtube.com/watch?v=dVvqGAjg_J8
- sooheon 3y agoStanfield's logic is simply wrong. 1. Spermidine found to increase lifespan and fertility in mice. 2. Spermidine levels not found to increase in blood or certain tissues when fed to mice. 3. Therefore, 1 is wrong. Finding 2 in no way disproves 1. Facts which could be consistent with both 1 and 2 being true: - spermidine metabolites are responsible for benefits - while spermidine levels are maintained, excess spermidine is used beneficially - experimenters in 2 simply haven't looked in the right tissues And so on. TFA says there were observed phenotypic improvements (follicular health, oocyte number and quality), which categorically trump 2's failure to observe increase in spermidine levels. And none of this says anything directly about spermidine's effects in humans
- yazaddaruvala 3y agoI’ve watched a lot of Stanfield’s videos. Over time I came to realize that his whole image is built on being “the critic” and tempering optimism around these treatments. Except for his own personal research, which he’d like you to help fund :) At the end of the day, “the critic” is a valuable job. Someone has to do it. Not sure it is really helping progress the industry though. I think it would be better for him to leave this to the lawyers tho.
- M95D 3y agoBut more fertility is not what we need!
- goda90 3y agoIt mentions egg quality. If that impacts development of the fetus as well, it could mean those who wait to have a single child at an older age are less likely to see negative health impacts due to mother's age.
- 93po 3y agoIs it not? A ton of money is spent on fertility treatments by a lot of people
- M95D 3y agoSorry. I meant "Earth doesn't need more human fertility".
- bryanrasmussen 3y agothis is a dystopian apocalyptic Sci-Fi level side effect! Great story potentials.
- p0w3n3d 3y agocells that refuse to die are known as cancer. I hope (some) people won't become cancer of this planet
- BrainBacon 3y agoThis is not entirely true. Some brain cells and the cells in your eye lens will be there your entire life and could even potentially live longer if they were not limited by the rest of the body. Cancer is definitely a lot more than just immortal cells.
- prettyStandard 3y agoAgree with sibling comment. This is another indicator that that is not quite the right way to think about cancer. https://news.ycombinator.com/item?id=37839458 https://news.ycombinator.com/item?id=37839458
- CatWChainsaw 3y agoUsually mouse studies get a flood of comments about how they're mouse studies. I think it's interesting that there isn't really a flood this time when it's about aging/longevity, as a lot of people here seem to be immortalists. Hope and faith take you places, I guess.
- vagab0nd 3y agoThe title says "in ageing mice". Why repeat it?
- CatWChainsaw 3y agoWhy does your reply point out what I pointed out?