4 ms·
> boosting ourantibody response What I wonder is if we can develop immunity (not boosting, assuming never been infected before) from being exposed to small dos
by dorfsmay 3y ago
> boosting ourantibody response
What I wonder is if we can develop immunity (not boosting, assuming never been infected before) from being exposed to small doses, or do we need at least one full blown infection.
- jameshart 3y agoNot sure why you are suggesting the basic mechanism of inoculation, which has been known for centuries and is the fundamental mechanism behind vaccination, as if it’s a novel hypothesis. Have I misunderstood what you’re getting at?
- beebeepka 3y agoI think your understanding is fine. A friend of my wife once came up with the novel idea of renting books out of big buildins that are loaded with books. Brain farts happen to all of us
- dorfsmay 3y agoDosage. Vaccines use deactivated viruses, but I don't think they use "tiny amount".
- kbutler 3y agohttps://www.cdc.gov/smallpox/history/history.html https://www.cdc.gov/smallpox/history/history.html To test his theory, Dr. Jenner took material from a cowpox sore on milkmaid Sarah Nelmes’ hand and inoculated it into the arm of James Phipps, the 9-year-old son of Jenner’s gardener. Months later, Jenner exposed Phipps several times to variola virus, but Phipps never developed smallpox. More experiments followed, and, in 1801, Jenner published his treatise “On the Origin of the Vaccine Inoculation.” ... Vaccination became widely accepted and gradually replaced the practice of variolation. At some point in the 1800s, the virus used to make the smallpox vaccine changed from cowpox to vaccinia virus.
- vikramkr 3y agoYep that's called vaccination! No need to get a full blown infection it's how we eradicated smallpox
- dilyevsky 3y agoThat’s not vaccination that’s inoculation which is how they originally prevented smallpox before they developed an actual vaccine
- vikramkr 3y agoIts responsive to the parent question in that yes, we can have symptomless exposure to the infectious agent (or some part of it) and develop immunity. Maybe the distinction between using unweakened live pathogens and weakened or fragmented pathogens should have been emphasized but that didn't seem to the important part of the question
- dorfsmay 3y agoThanks, that was indeed my question. It'd be interesting to understand if that's true for all viruses and in what quantities. For example, in the early days of COVID, we were told that being close to infected people outdoor did not expose us to enough viruses to get infected. Could such exposure have provided immunity?
- dorfsmay 3y agoVaccination is using deactivated viruses. My question is can we get the same effect from exposure to small doses of live viruses. The articles says exposure to tiny amount can "boost" immunity, which I assume means an immunity acquired earlier from a full blown infection (or vaccination).
- malfist 3y agoVaccination can use deactivated viruses, but not always.
- 3y ago
- refurb 3y agoGenerally the stronger the immune response, the more effective the future immunity (not always).