3 ms·
>One hurdle that will need to be overcome is that NF-Y also regulates important processes in healthy cells, such as metabolism and the cell cycle, the series of
by biogene 3y ago
>One hurdle that will need to be overcome is that NF-Y also regulates important processes in healthy cells, such as metabolism and the cell cycle, the series of steps that cells go through as they grow and divide. However, Vakoc and team hypothesize that because RMS cells are "highly sensitive" to changes in PAX3-FOXO1 expression, there could be a "window of opportunity" in which a drug inhibits NF-Y long enough for RMS cells to differentiate but not so long that healthy tissues get damaged.
Author buried the most important "but.." in the last paragraph. Lets keep "sciencing", but this is just a catchy headline.
- lumost 3y agoI'd be curious if one could use CRISPR to reprogram cancer cells to the point that the immune system starts killing them again. Or did this work not have any targeting?
- Gibbon1 3y agoImmunotherapy drugs I think work by interfering with cancer cells ability to suppress or evade the immune system. So possible. I think basically all pathogens and many cancers have to have some way to delay, suppress or evade immunity or they get quickly dealt with. Seems to have become a very active area of research in the last 20 years.