We don't use HDF5. Just look at the numbers for OME-NGFF and TIFF. We have already tried EFS and it worked for our needs but cost about the same as your EBS.

We don't use HDF5. Just look at the numbers for OME-NGFF and TIFF. We have already tried EFS and it worked for our needs but cost about the same as your EBS. We had to enable the "EFS go fast" button (at least it exists!) which greatly increases the cost.