You're (correctly) addressing some of the issues in biomedical research but even the most rigorous and validated science does not necessarily translate into cli

You're (correctly) addressing some of the issues in biomedical research but even the most rigorous and validated science does not necessarily translate into clinical outcomes for a laundry list of reasons. Evidence based medicine includes lab/animal studies (i.e. scientific literature in biology) but when we talk about EBM what we really mean is "outcomes based medicine" rather than relying on the science. EBM reduces the question to "Does intervention X change clinical outcome Y in population Z" to obviate many (but not all) of the clinical translation issues.