6 ms·
> Severe hypoglycemia to the point of what was described (death) is not reported in any of the recent device studies. Are there large-scale studies that show t
by awaywethrow 3y ago
> Severe hypoglycemia to the point of what was described (death) is not reported in any of the recent device studies.
Are there large-scale studies that show this for a dual hormone control algorithm (the context of this thread)?
- haldujai 3y agoYou seem to be misunderstanding how these devices work. Bihormonal pumps do not mean continuous infusions of both insulin and glucagon. The pumps pulse insulin when you're high and glucagon when you're low. They're not both administered at the same time or continuously infused in a "balanced state". The context in this thread: > However, if your brakes (glucagon) can sometimes fail completely A bihormonal system would not result in more insulin being administered than an insulin-only system for a given blood sugar, if the glucagon pump fails we would have an insulin-only system where we have plenty of safety data. There is no mechanism by which a bihormonal system has higher risk of hypoglycemia than existing closed loop insulin system.
- awaywethrow 3y agoTo clarify, the context of this thread / what I was originally responding to was: > In this case, you could be more aggressive in either direction of pushing BG, because you have a safety net.