> Agree that patient input shouldn't be necessary, but to replace it we will need to include other inputs besides CGM in a systematic way to get the optimal res

> Agree that patient input shouldn't be necessary, but to replace it we will need to include other inputs besides CGM in a systematic way to get the optimal results. I'm not going as far as to claim Medtronic's approach (I believe the only one commercially available with so-called meal prediction based on historical CGM and offers full correction boluses) is the optimal one, just that it is an approach that is at least very good (~80% time in target) and while it still requires meal announcements it's just the first step of what they're trying to do. Clearly we can expect further iterations of these algorithms as the technology matures. > Inreda uses two identical CGMs for noise reduction purposes just so they can get clean data with less of a lag. Just giving an example that this is possible without external input or data, your statement was that you will need a-priori information which is not necessarily the case. Whether such a system is optimal is a different question. I haven't seen the raw data and highly doubt enough of it even exists for anyone to make a claim whether or not such a system can be optimized to the point necessary. > None of the systems claiming you don't have to do anything in terms of meal announcement are _working_ in the sense of achieving euglycemic parity, which should be the goal. For clarity to any less knowledgeable readers while time spent in euglycemia is a very important outcome measure it cannot come at the expense of severe hypoglycemia or severe hyperglycemia/diabetic ketoacidosis (i.e. an algorithm that improves euglycemia to 95% but has a 2% severe hypo time is less acceptable than 80% euglycemia and 0.5% severe hypo.) To my knowledge no system on the market/generally available right now is claiming to be completely input free. The closest to my knowledge is again the MiniMed 780G discussed in my first point which will assuredly be iterated on. Also to be clear I'm not being dismissive of what your company is working on, it's a very interesting and novel approach. It may even be necessary to achieve the optimal product. I look forward to reading about your results when you publish them. I'm just presenting alternatives and a brief overview of what other approaches are for HN readers who are likely unfamiliar with the topic being discussed.