3 ms·

Do you just inject stem cells into the affected area?

rolph 3y ago
thats a simple approach, application of a pseudo tissue similar to skingrafting is another, implantation of 'scaffold' protien construct, implanted with stem cells is another. e.g. 'ghost' organs or tissue, grafting. a somewhat complex approach is to "wipe" [dedifferentiate] in situ stem cells in vivo, allowing surrounding tissue signaling to program stem cells and induce a developmental path. keep in mind i am being simple for the sake of understanding.
- orliesaurus 3y ago
  Can anything go wrong with these approaches? Like what is the rejection rate, is there even a rejection rate? Curious, I know nothing!
  - rolph 3y ago
    to keep it simple, this is just scratching the surface of what is there. teratogenesis is a major hurdle to the tech. to a large extent it is induction of a process that is autonomously regulated. consider, the gotchas involved in reusing materials to produce structure. or the complexity involved in changing the nature of a large multinational conglomerate of corporations. the difficulty lies in 're-vectoring' an assembly to alter process that is dynamic and has many possible responses to one specific change, dependent on past event, multiplied by each cell in the respondent cohort. assembly theory, and informatic complexity apply here, overtop the biological phenomenon. ============================ rejection rate is ideally not a consequence when these stem cells originate from the recipient. the tech of topic deals with genetic manipulation, and is simplistic as DNA is not the only component having influence. cytoplasmic factors, as well as the state, and point of process are informatic and determinative.
    - orliesaurus 3y ago
      Thank you for explaining it to me!
moffkalast 3y ago
Apply stem cells directly to the forehead.
haldujai 3y ago
You would probably want to induce differentiation in vitro before injecting to make sure it turns into the right cell type but stem cell therapy hasn’t worked out particularly well. One of the easiest problems to understand is that the cellular potential for infinite replication is what causes tumors/cancers too.

thats a simple approach, application of a pseudo tissue similar to skingrafting is another, implantation of 'scaffold' protien construct, implanted with stem cells is another. e.g. 'ghost' organs or tissue, grafting. a somewhat complex approach is to "wipe" [dedifferentiate] in situ stem cells in vivo, allowing surrounding tissue signaling to program stem cells and induce a developmental path. keep in mind i am being simple for the sake of understanding.

orliesaurus 3y ago
Can anything go wrong with these approaches? Like what is the rejection rate, is there even a rejection rate? Curious, I know nothing!
- rolph 3y ago
  to keep it simple, this is just scratching the surface of what is there. teratogenesis is a major hurdle to the tech. to a large extent it is induction of a process that is autonomously regulated. consider, the gotchas involved in reusing materials to produce structure. or the complexity involved in changing the nature of a large multinational conglomerate of corporations. the difficulty lies in 're-vectoring' an assembly to alter process that is dynamic and has many possible responses to one specific change, dependent on past event, multiplied by each cell in the respondent cohort. assembly theory, and informatic complexity apply here, overtop the biological phenomenon. ============================ rejection rate is ideally not a consequence when these stem cells originate from the recipient. the tech of topic deals with genetic manipulation, and is simplistic as DNA is not the only component having influence. cytoplasmic factors, as well as the state, and point of process are informatic and determinative.
  - orliesaurus 3y ago
    Thank you for explaining it to me!

moffkalast 3y ago

Apply stem cells directly to the forehead.

haldujai 3y ago

You would probably want to induce differentiation in vitro before injecting to make sure it turns into the right cell type but stem cell therapy hasn’t worked out particularly well. One of the easiest problems to understand is that the cellular potential for infinite replication is what causes tumors/cancers too.